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Protocol No. UW19092

Principal Investigator Barroilhet, Lisa

Phase N/A

Age Group Adult

Scope Local

Sponsor Type Institutional

Title Hormone Replacement Therapy Use by Women at High risk of Breast and Ovarian Cancer after Bilateral Risk-Reducing Salpingo-Oophorectomy

Objective The purpose of this research study is to learn about the use of hormones after ovary removal, as well as to assess overall cancer worry in the setting of increased genetic risk. We are doing this study because researchers would like to know if women are using hormone replacement therapy after their surgery; if so, for how long, and if not (or therapy was stopped), why it was not used (or stopped)

Treatment NA

Description Hormone Replacement Therapy Use by Women at High Risk of Breast and Ovarian Cancer after Risk-Reducing Bilateral Salpingo-Oophorectomy

Key Eligibility
  • 18 years of age or older
  • Known BRCA1 and/or BRCA2 mutation carriers or
  • Known homologous recombination repair gene mutations in candidate genes BARD1,BRIP1, PALB2, RAD51C, RAD51D or
  • Known mutations in mismatch repair genes conferring Lynch Syndrome, including MLH1, MSH2, MSH6, PMS2
  • Those with a documented first-degree relative affected by ovarian cancer, without a confirmed hereditary mutation present
  • Subjects will have undergone prophylactic risk-reducing bilateral salpingo-oophorectomy (could be removal of second ovary after first was performed for benign condition) one year or more prior to survey
  • At least one visit at the High Risk Breast and Ovarian Cancer Clinic at UW Carbone Cancer Center
  • Records available in either UW EPIC or Care Everywhere
  • Underwent prophylactic surgery between January 1, 2000- December 31, 2019
    Exclusion Criteria:
  • Diagnosis of ovarian cancer prior to surgery
  • Surgery for ovarian suppression in the setting of breast cancer
  • Surgery completed less than one year before survey

  • Applicable Disease Sites Breast; Ovary

    Status Open

    Participating Institutions UW Hospital and Clinics