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Protocol No. UW17141

Principal Investigator Wilson, Elizabeth

Phase N/A (Cancer Control)

Age Group Adult

Scope Local

Sponsor Type Institutional

Title A Comparison of the Paravertebral Block Versus Pectoralis Block in Controlling Bilateral Post-Mastectomy Pain in Setting of Tissue Expander

Objective The purpose of this study is to learn how to best treat and prevent acute (short-term) and chronic (long-term) pain that occurs after having a mastectomy operation. A nerve block is a local anesthetic (numbing medicine placed around nerves affected by the surgery to help with pain). It is routine practice to receive a nerve block prior to mastectomy surgery to help you with your pain after surgery. We will be comparing two nerve blocks, each placed in a different location. One block is known as the pectoralis block (PECs II) where the local anesthetic is placed in the front part of the chest. The other block is known as the paravertebral (PVB) nerve block where the local anesthetic is placed in the back. We want to know which nerve block decreases long-term opioid consumption and post-operative nausea the most

Treatment If you decide to be in this research study, researchers will randomly assign you to one of two groups. Randomly assign means that you will be assigned by chance - like by flipping a coin –and you will have an equal chance of being assigned to either of the two groups:
  • Group 1: PECs II nerve block (numbing medicine placed in the front part of your chest while you are laying flat)
  • Group 2: PVB nerve block (numbing medicine placed in your back while you are sitting upright)

  • Description Paravertebral vs. Pectoralis Blocks for Post Mastectomy Pain

    Key Eligibility Each patient must meet all of the following inclusion criteria to be enrolled in the study.
  • The clinical decision has been made that the patient will have a bilateral mastectomy with tissue expander placement
  • The patient is greater than or equal to 18 years and less than or equal to 80 years
  • Weight greater than or equal to 60 kg and less than or eqaul to 90 kg
  • The patient’s primary anesthesia care team has planned for general anesthesia
  • The patient agrees to receive a regional block
  • American Society of Anesthesiologists class 1-3
    Patients meeting any of the following exclusion criteria are not to be enrolled in the study:
  • less than 18 years of age or greater than 80 years of age
  • less than 60 kg or more than 90 kg
  • Non-English speaking
  • Known or believed to be pregnant
  • Patient has impaired decision-making capacity per discretion of the Investigator
  • Standard contraindications to regional blocks
  • Significant renal, cardiac or hepatic disease
  • A clinical decision made that indicates need for a partial or complete axillary node dissection
  • American Society of Anesthesiologists class 4-5
  • Known hypersensitivity and/or allergies to local anesthetics
  • Chronic Opioid Use (daily or almost daily use of opioids for greater than 3 months)

  • Applicable Disease Sites Breast

    Status Open

    Participating Institutions UW Hospital and Clinics