Print Friendly Page

Protocol No. UW13115

Principal Investigator Sippel, Rebecca

Phase II (Cancer Prevention)

Age Group Adult

Scope Local

Sponsor Type Externally Peer-Reviewed; Institutional

Title Central Neck Dissection in Patients with Clinical Node Negative Thyroid Cancer

Objective The purpose of this research study is to compare people who will only have their thyroid gland removed to those who will have their thyroid gland and surrounding lymph nodes removed to learn if people are more or less likely to experience complications or the return of their cancer.

Treatment If only the thyroid is removed, it is believed there are fewer surgical complications, but there might be a higher chance that the thyroid cancer could come back. This is the standard of care at UW-Madison hospital. If the thyroid is removed along with all the surrounding, health-looking lymph nodes, it is believed the chances of experiencing surgical complications could rise, but the chance of thyroid cancer coming back may go down. It is hoped that the study data will provide sufficient evidence to recommend one treatment over the other.

Description If you decide to be part of this study you will be randomly assigned (like a flip of a coin) to one of two groups. One group will receive removal of the thyroid gland and the second group will receive removal of the thyroid gland and lymph nodes near the thyroid. You will not know which surgery you had until you return to your doctor's office one to two weeks later for a follow up appointment when your pathology report will be reviewed. Click here for more info

Key Eligibility
  • Pre-operative diagnosis or suspicion of papillary thyroid cancer
  • No pre-operative evidence of cervical lymph node metastases on neck ultrasound
  • No evidence of distant metastases
  • Age 21-73 years
  • Not eligible if largest papillary thyroid carcinoma <1 cm in size on ultrasound
  • Not eligible if patient has had previous thyroid surgery
  • Not eligible if patient has pre-existing vocal cord paralysis
  • Not eligible if patient has T4 tumor
  • Not eligible if patient has a chronic neurologic condition which affects voice or swallow (for instance, multiple sclerosis or Parkinson disease

Applicable Disease Sites Thyroid

Therapies Involved Surgery

Status Open

Participating Institutions UW Hospital and Clinics