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Gregory M. Gauthier, MD

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Gregory M. Gauthier, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Gauthier’s research seeks to understand the pathogenesis of the thermally dimorphic fungi at the molecular level using Blastomyces dermatitidis as a model organism.  As a physician-scientist his goal is to bring the research findings at the bench into the clinic to improve the care and clinical outcomes of patients with invasive fungal infections. 


Infectious Diseases


University Hospital
(608) 263-0946 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Infectious Diseases
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship University of Wisconsin Hospital and Clinics, Madison, WI
Medical School The Ohio State University College of Medicine, Columbus, OH

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
PubMed Articles
Laux KL Anderson JL Bentivenga SP McBride JA Sterkel A Matkovic E Gauthier GM Meece JK Urine Antigen Testing is Equally Sensitive to <i>B. dermatitidis</i> and <i>B. gilchristii</i> Infections. Clin Med Res . 2020 Jun 22;
[PubMed ID: 32571776]
McBride JA Sterkel AK Matkovic E Broman AT Gibbons-Burgener SN Gauthier GM Clinical Manifestations and Outcomes in Immunocompetent and Immunocompromised Patients with Blastomycosis. Clin Infect Dis . 2020 Mar 17;
[PubMed ID: 32179889]
McBride JA Gauthier GM Klein BS Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of <i>Blastomyces</i>. Virulence . 2019 Dec;10(1):801-809
[PubMed ID: 29532714]
Lacerda Pigosso L Baeza LC Vieira Tomazett M Batista Rodrigues Faleiro M Brianezi Dignani de Moura VM Melo Bailão A Borges CL Alves Parente Rocha J Rocha Fernandes G Gauthier GM Soares CMA Paracoccidioides brasiliensis presents metabolic reprogramming and secretes a serine proteinase during murine infection. Virulence . 2017 Oct 3;8(7):1417-1434
[PubMed ID: 28704618]
McBride JA Gauthier GM Klein BS Clinical Manifestations and Treatment of Blastomycosis. Clin Chest Med . 2017 Sep;38(3):435-449
[PubMed ID: 28797487]
Gauthier GM Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival. Mediators Inflamm . 2017;2017:8491383
[PubMed ID: 28626345]
Schmutz JS Ramey NA Gauthier GM Lucarelli MJ Severe Oculofacial Sequelae of Cutaneous Blastomyces dermatitidis. Ophthalmic Plast Reconstr Surg . 2016 May-Jun;32(3):e61-2
[PubMed ID: 25098446]
Muñoz JF Gauthier GM Desjardins CA Gallo JE Holder J Sullivan TD Marty AJ Carmen JC Chen Z Ding L Gujja S Magrini V Misas E Mitreva M Priest M Saif S Whiston EA Young S Zeng Q Goldman WE Mardis ER Taylor JW McEwen JG Clay OK Klein BS Cuomo CA The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia. PLoS Genet . 2015 Oct;11(10):e1005493
[PubMed ID: 26439490]
Marty AJ Broman AT Zarnowski R Dwyer TG Bond LM Lounes-Hadj Sahraoui A Fontaine J Ntambi JM KeleÅŸ S Kendziorski C Gauthier GM Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis. PLoS Pathog . 2015 Jun;11(6):e1004959
[PubMed ID: 26114571]
Gauthier GM Dimorphism in fungal pathogens of mammals, plants, and insects. PLoS Pathog . 2015 Feb;11(2):e1004608
[PubMed ID: 25675433]
Silva-Bailão MG Bailão EF Lechner BE Gauthier GM Lindner H Bailão AM Haas H de Almeida Soares CM Hydroxamate production as a high affinity iron acquisition mechanism in Paracoccidioides spp. PLoS One . 2014;9(8):e105805
[PubMed ID: 25157575]
Gauthier GM Keller NP Crossover fungal pathogens: the biology and pathogenesis of fungi capable of crossing kingdoms to infect plants and humans. Fungal Genet Biol . 2013 Dec;61:146-57
[PubMed ID: 24021881]
Marty AJ Wüthrich M Carmen JC Sullivan TD Klein BS Cuomo CA Gauthier GM Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling. Fungal Genet Biol . 2013 Jul;56:1-8
[PubMed ID: 23499858]
Marty AJ Gauthier GM Blastomyces dermatitidis septins CDC3, CDC10, and CDC12 impact the morphology of yeast and hyphae, but are not required for the phase transition. Med Mycol . 2013 Jan;51(1):93-102
[PubMed ID: 22783804]
Saucier J Gauthier G Photo quiz. Verrucous lesions and ectropion in an immunocompetent individual. Clin Infect Dis . 2012 Nov 15;55(10):1390-1, 1426-8
[PubMed ID: 23091045]
Krajaejun T Wüthrich M Gauthier GM Warner TF Sullivan TD Klein BS Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence. Infect Immun . 2010 Jun;78(6):2522-8
[PubMed ID: 20368350]
Gauthier GM Sullivan TD Gallardo SS Brandhorst TT Vanden Wymelenberg AJ Cuomo CA Suen G Currie CR Klein BS SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog . 2010 Apr 1;6(4):e1000846
[PubMed ID: 20368971]
Brandhorst TT Gauthier GM Stein RA Klein BS Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis. J Biol Chem . 2005 Dec 23;280(51):42156-63
[PubMed ID: 16243837]
Gauthier GM Keevil JG McBride PE The association of homocysteine and coronary artery disease. Clin Cardiol . 2003 Dec;26(12):563-8
[PubMed ID: 14677809]
Gauthier GM Dieter RS Successful treatment of a femoral artery pseudoaneurysm mimicking a deep venous thrombosis following cardiac catheterization. Catheter Cardiovasc Interv . 2002 Sep;57(1):75-8
[PubMed ID: 12203934]