Timothy J. Kamp, MD, PhD, FACC Print Friendly Page
Faculty, University of Wisconsin School of Medicine and Public HealthDr. Kamp's clinical activities include general cardiology with an emphasis on noninvasive cardiac electrophysiology and heart failure. He directs an active research program which bridges from the basic functional and electrical properties of heart cells to clinical applications arising from these basic studies, including the use of stem cells to repair damaged heart muscle. Dr. Kamp participates widely in peer review activities, including the editorial board for the journals Circulation Research and Stem Cells, as well as serving on peer review panels for American Heart Association and National Institutes of Health.
Specialties
UW Health Clinics
Hospital Affiliation(s)
University Hospital (primary)
UnityPoint Health - Meriter, Veterans Hospital - Wm. S. Middleton Memorial (secondary)
UW School of Medicine and Public Health
| Department of Medicine |
Professional Certifications and Education
| Board Certification |
Cardiovascular Disease
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| Fellowship |
The The The Johns Hopkins Hospital, Baltimore, MD
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| Residency |
The The The Johns Hopkins Hospital, Baltimore, MD
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| Internship |
The The The Johns Hopkins Hospital, Baltimore, MD
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| Medical School |
University of Chicago Medical School, Chicago, IL, 1989
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| Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000. |
Programs & Conditions
| Research |
Dr. Kamp's research focuses in three general and related areas: (1) cardiac ion channel proteins and their role in the electrical activity of the heart, including arrhythmias, (2) basic cellular abnormalities responsible for heart failure, and (3) stem cells for the generation of new heart cells and for repair of damaged heart muscle. |
PubMed Articles
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Nelson DO Lalit PA Biermann M Markandeya YS Capes DL Addesso L Patel G Han T John MC Powers PA Downs KM Kamp TJ Lyons GE .
Irx4 Marks a Multipotent, Ventricular-Specific Progenitor Cell. Stem Cells. 2016 Aug 29;
[PubMed ID: 27570947]
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Vaidyanathan R Markandeya YS Kamp TJ Makielski JC January CT Eckhardt LL .
IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1611-21
[PubMed ID: 27059077]
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Biermann M Kamp TJ .
Cardiotoxicity in a dish: new insights for personalized therapy. Nat Med. 2016 May 5;22(5):459-60
[PubMed ID: 27149216]
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Lalit PA Salick MR Nelson DO Squirrell JM Shafer CM Patel NG Saeed I Schmuck EG Markandeya YS Wong R Lea MR Eliceiri KW Hacker TA Crone WC Kyba M Garry DJ Stewart R Thomson JA Downs KM Lyons GE Kamp TJ .
Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors. Cell Stem Cell. 2016 Mar 3;18(3):354-67
[PubMed ID: 26877223]
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Brody MJ Feng L Grimes AC Hacker TA Olson TM Kamp TJ Balijepalli RC Lee Y .
LRRC10 is required to maintain cardiac function in response to pressure overload. Am J Physiol Heart Circ Physiol. 2016 Jan 15;310(2):H269-78
[PubMed ID: 26608339]
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Hwang HS Kryshtal DO Feaster TK Sánchez-Freire V Zhang J Kamp TJ Hong CC Wu JC Knollmann BC .
Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full. J Mol Cell Cardiol. 2015 Dec;89(Pt B):379-80
[PubMed ID: 26695095]
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Wendel JS Ye L Tao R Zhang J Zhang J Kamp TJ Tranquillo RT .
Functional Effects of a Tissue-Engineered Cardiac Patch From Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Rat Infarct Model. Stem Cells Transl Med. 2015 Nov;4(11):1324-32
[PubMed ID: 26371342]
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Hwang HS Kryshtal DO Feaster TK Sánchez-Freire V Zhang J Kamp TJ Hong CC Wu JC Knollmann BC .
Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. J Mol Cell Cardiol. 2015 Aug;85:79-88
[PubMed ID: 25982839]
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Chang YH Ye L Cai W Lee Y Guner H Lee Y Kamp TJ Zhang J Ge Y .
Quantitative proteomics reveals differential regulation of protein expression in recipient myocardium after trilineage cardiovascular cell transplantation. Proteomics. 2015 Aug;15(15):2560-7
[PubMed ID: 26033914]
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Lian X Bao X Zilberter M Westman M Fisahn A Hsiao C Hazeltine LB Dunn KK Kamp TJ Palecek SP .
Chemically defined, albumin-free human cardiomyocyte generation. Nat Methods. 2015 Jul;12(7):595-6
[PubMed ID: 26125590]
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Markandeya YS Kamp TJ .
Rational strategy to stop arrhythmias: Early afterdepolarizations and L-type Ca2+ current. J Gen Physiol. 2015 Jun;145(6):475-9
[PubMed ID: 26009542]
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Kamp TJ January CT .
Harry A. Fozzard, MD: 1931–2014. Circ Res. 2015 Feb 13;116(4):552-3
[PubMed ID: 25821880]
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Raval KK Tao R White BE De Lange WJ Koonce CH Yu J Kishnani PS Thomson JA Mosher DF Ralphe JC Kamp TJ .
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. J Biol Chem. 2015 Jan 30;290(5):3121-36
[PubMed ID: 25488666]
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Bhattacharya D Mehle A Kamp TJ Balijepalli RC .
Intramolecular ex vivo Fluorescence Resonance Energy Transfer (FRET) of Dihydropyridine Receptor (DHPR) β1a Subunit Reveals Conformational Change Induced by RYR1 in Mouse Skeletal Myotubes. PLoS One. 2015;10(6):e0131399
[PubMed ID: 26114725]
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Wrighton PJ Klim JR Hernandez BA Koonce CH Kamp TJ Kiessling LL .
Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18126-31
[PubMed ID: 25422477]
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Ye L Chang YH Xiong Q Zhang P Zhang L Somasundaram P Lepley M Swingen C Su L Wendel JS Guo J Jang A Rosenbush D Greder L Dutton JR Zhang J Kamp TJ Kaufman DS Ge Y Zhang J .
Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell. 2014 Dec 4;15(6):750-61
[PubMed ID: 25479750]
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Bedada FB Chan SS Metzger SK Zhang L Zhang J Garry DJ Kamp TJ Kyba M Metzger JM .
Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes. Stem Cell Reports. 2014 Oct 14;3(4):594-605
[PubMed ID: 25358788]
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Fox IJ Daley GQ Goldman SA Huard J Kamp TJ Trucco M .
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science. 2014 Aug 22;345(6199):1247391
[PubMed ID: 25146295]
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Spencer CI Baba S Nakamura K Hua EA Sears MA Fu CC Zhang J Balijepalli S Tomoda K Hayashi Y Lizarraga P Wojciak J Scheinman MM Aalto-Setälä K Makielski JC January CT Healy KE Kamp TJ Yamanaka S Conklin BR .
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports. 2014 Aug 12;3(2):269-81
[PubMed ID: 25254341]
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Raval KK Kamp TJ .
Cardiomyopathy, mitochondria and Barth syndrome: iPSCs reveal a connection. Nat Med. 2014 Jun;20(6):585-6
[PubMed ID: 24901565]
