Kenneth B. DeSantes, MD close

Kenneth B. DeSantes, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Kenneth De Santes completed his general pediatric training at Children's Hospital of Los Angeles and his pediatric hematology/oncology training at Children's Hospital and Medical Center, and the Fred Hutchinson Cancer Research Center in Seattle. He worked in the division of Bone Marrow Transplantation at the University of California, San Francisco for seven years before accepting a faculty position at the University of Wisconsin.


Dr. De Santes is the Clinical Director of the Pediatric Hematology/Oncology program, and Director of the Hematopoietic Stem Cell Transplant program at the American Family Children’s Hospital. He is a member of the American Pediatric Society, the American Society of Pediatric Hematology and Oncology, the American Society of Blood and Marrow Transplantation, the Children’s Oncology Group, and the Pediatric Blood and Marrow Transplant Consortium. Dr. De Santes also serves as a consultant for Best Doctors®, and the Chartwell Medical Advisory Board. He has written six book chapters and published over 30 research articles. His research interests include the treatment of neuroblastoma, and the use of immunotherapy and stem cell transplantation to treat pediatric cancer.


Pediatric Hematology and Oncology

Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

Adrenocortical carcinoma

Aplastic Anemia



Atypical Teratoid/Rhabdoid tumor

Bone Marrow Biopsy

Brain Stem Glioma

CAR T-cell Therapy (Pediatric)


Chronic Myeloid Leukemia

Congenital Hemolytic Anemias


Cyclic Neutropenia

Diamond-Blackfan Syndrome

Endocrine Tumors


Ewing Sarcoma

Fanconi's Anemia

Germ Cell Tumors

Hemophagocytic Lymphohistiocytosis

Hemophilia A

Hemophilia B


Hereditary Spherocytosis

Hodgkin's Disease

I-131 MIBG (Metaiodobenzylguadine)

Immune Thrombocytopenc Purpura


Juvenile Myelomonocytic Leukemia

Kostmann Syndrome

Langerhans' Cell Histiocytosis

Lumbar Puncture


Myelodysplastic Syndromes



Neurocutaneous Syndrome


Non-Hodgkin Lymphomas

Optic Glioma


Paroxysmal Nocturnal Hemoglobinuria

Pediatric Bone Marrow Transplant

Pediatric Cancer

Pediatric Sickle Cell Disease




Shwachman-Diamond Syndrome

Sturge-Weber Syndrome

Thalassemia Syndromes


Thyroid Tumors

Tuberous Sclerosis

Vascular malformations

Von Willebrand Disease

VonHippel-Lindau Disease

Wilms Tumor


American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map
American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatric Hematology-Oncology
Fellowship Children's Hospital and Medical Center, Seattle, WA
Residency Children's Hospital of Los Angeles, Los Angeles, CA
Internship Children's Hospital of Los Angeles, Los Angeles, CA
Medical School New York Medical College, New York, NY

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. De Santes' research interests are focused on the utilization of natural killer (NK) cells to treat a wide variety of pediatric malignancies and developing novel stem cell transplant protocols for children with recurrent leukemia and high-risk solid tumors. He also is establishing more effective ways to utilize I-131 MIBG therapy for children with neuroblastoma.

PubMed Articles
Kim M Rao S Eickhoff JC DeSantes KB Capitini CM A Retrospective Analysis of Antithrombin III Replacement Therapy for the Treatment of Hepatic Sinusoidal Obstruction Syndrome in Children Following Hematopoietic Stem Cell Transplantation. J Pediatr Hematol Oncol . 2019 Jan 22;
[PubMed ID: 30676436]
Haddad E Logan BR Griffith LM Buckley RH Parrott RE Prockop SE Small TN Chaisson J Dvorak CC Murnane M Kapoor N Abdel-Azim H Hanson IC Martinez C Bleesing JJH Chandra S Smith AR Cavanaugh ME Jyonouchi S Sullivan KE Burroughs L Skoda-Smith S Haight AE Tumlin AG Quigg TC Taylor C Dávila Saldaña BJ Keller MD Seroogy CM Desantes KB Petrovic A Leiding JW Shyr DC Decaluwe H Teira P Gillio AP Knutsen AP Moore TB Kletzel M Craddock JA Aquino V Davis JH Yu LC Cuvelier GDE Bednarski JJ Goldman FD Kang EM Shereck E Porteus MH Connelly JA Fleisher TA Malech HL Shearer WT Szabolcs P Thakar MS Vander Lugt MT Heimall J Yin Z Pulsipher MA Pai SY Kohn DB Puck JM Cowan MJ O'Reilly RJ Notarangelo LD SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery. Blood . 2018 Oct 25;132(17):1737-1749
[PubMed ID: 30154114]
McCabe KE Pollock AJ Rehm JL DeSantes KB Curative potential of allogeneic hematopoietic stem cell transplant in type 1 diabetes. Pediatr Diabetes . 2017 Dec;18(8):832-834
[PubMed ID: 27572817]
Wang W Erbe AK DeSantes KB Sondel PM Donor selection for ex vivo-expanded natural killer cells as adoptive cancer immunotherapy. Future Oncol . 2017 May;13(12):1043-1047
[PubMed ID: 28492088]
McDowell KA Hank JA DeSantes KB Capitini CM Otto M Sondel PM NK cell-based immunotherapies in Pediatric Oncology. J Pediatr Hematol Oncol . 2015 Mar;37(2):79-93
[PubMed ID: 25590232]
Capitini CM Otto M DeSantes KB Sondel PM Immunotherapy in pediatric malignancies: current status and future perspectives. Future Oncol . 2014;10(9):1659-78
[PubMed ID: 25145434]
Delgado D Webster DE DeSantes KB Durkin ET Shaaban AF KIR receptor-ligand incompatibility predicts killing of osteosarcoma cell lines by allogeneic NK cells. Pediatr Blood Cancer . 2010 Dec 15;55(7):1300-5
[PubMed ID: 20981688]
Delgado DC Hank JA Kolesar J Lorentzen D Gan J Seo S Kim K Shusterman S Gillies SD Reisfeld RA Yang R Gadbaw B DeSantes KB London WB Seeger RC Maris JM Sondel PM Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res . 2010 Dec 1;70(23):9554-61
[PubMed ID: 20935224]
Shusterman S London WB Gillies SD Hank JA Voss SD Seeger RC Reynolds CP Kimball J Albertini MR Wagner B Gan J Eickhoff J DeSantes KB Cohn SL Hecht T Gadbaw B Reisfeld RA Maris JM Sondel PM Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II study. J Clin Oncol . 2010 Nov 20;28(33):4969-75
[PubMed ID: 20921469]
Bunin NJ Davies SM Aplenc R Camitta BM DeSantes KB Goyal RK Kapoor N Kernan NA Rosenthal J Smith FO Eapen M Unrelated donor bone marrow transplantation for children with acute myeloid leukemia beyond first remission or refractory to chemotherapy. J Clin Oncol . 2008 Sep 10;26(26):4326-32
[PubMed ID: 18779619]
Gowans LK Bentz ML DeSantes KB Thompson KJ Successful treatment of an infant with constitutional chromosomal abnormality and hemangiopericytoma with chemotherapy alone. J Pediatr Hematol Oncol . 2007 Jun;29(6):409-11
[PubMed ID: 17551404]
Ramadan M Whalen B De Santes K Hyperexcitable Blink Reflex Preceding the Diagnosis of Neuroblastoma. J Pediatr Hematol Oncol . 2004 Oct;26(10):665-667
[PubMed ID: 27811609]
Ramadan M Whalen B De Santes K Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma. J Pediatr Hematol Oncol . 2004 Oct;26(10):665-7
[PubMed ID: 15454839]
Emile JF Geissmann F Martin OC Radford-Weiss I Lepelletier Y Heymer B Espanol T de Santes KB Bertrand Y Brousse N Casanova JL Fischer A Langerhans cell deficiency in reticular dysgenesis. Blood . 2000 Jul 1;96(1):58-62
[PubMed ID: 10891430]
O'Marcaigh AS Puck JM Pepper AE De Santes K Cowan MJ Maternal mosaicism for a novel interleukin-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency in a Navajo kindred. J Clin Immunol . 1997 Jan;17(1):29-33
[PubMed ID: 9049783]
De Santes KB Lai SS Cowan MJ Haploidentical bone marrow transplants for two patients with reticular dysgenesis. Bone Marrow Transplant . 1996 Jun;17(6):1171-3
[PubMed ID: 8807131]
De Santes K Slamon D Anderson SK Shepard M Fendly B Maneval D Press O Radiolabeled antibody targeting of the HER-2/neu oncoprotein. Cancer Res . 1992 Apr 1;52(7):1916-23
[PubMed ID: 1348016]