Kenneth B. DeSantes, MD close

Kenneth B. DeSantes, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Kenneth DeSantes is the Division Head of Pediatric Hematology, Oncology and Bone Marrow Transplant where he leads all clinical care and the fellowship program. He earned his medical degree from New York Medical College, completed his general pediatric training at Children's Hospital of Los Angeles and his pediatric hematology/oncology fellowship at Children's Hospital and Medical Center and the Fred Hutchinson Cancer Research Center, Seattle, WA. Prior to joining the University of Wisconsin School of Medicine and Public Health, he was in the division of Bone Marrow Transplantation at the University of California, San Francisco. 

Dr. DeSantes is board certified in pediatric hematology/oncology, is a member of the Society for Immunotherapy of Cancer, the International Society of Pediatric Oncology, the Pediatric Cancer Immunotherapy Trials Network, the SU2C/St. Baldrick’s Pediatric Oncology Dream Team, the American Society of Pediatric Hematology and Oncology, the American Society of Transplant and Cellular Therapy, the Children’s Oncology Group and the Pediatric Transplant and Cellular Therapy Consortium. 

Dr. De Santes also serves as a consultant for Best Doctors®. He has written six book chapters and published over 50 research articles. His research interests are focused on the utilization of natural killer (NK) cells to treat a wide variety of pediatric malignancies and developing novel stem cell transplant protocols for children with recurrent leukemia and high-risk solid tumors. He also is establishing more effective ways to utilize I-131 MIBG therapy for children with neuroblastoma. 


Pediatric Hematology and Oncology

Acute Lymphoblastic Leukemia

Adrenocortical carcinoma

Aplastic Anemia



Atypical Teratoid/Rhabdoid tumor

Bone Marrow Biopsy

Brain Stem Glioma

CAR T-cell Therapy (Pediatric)


Chronic Myeloid Leukemia

Congenital Hemolytic Anemias


Cyclic Neutropenia

Diamond-Blackfan Syndrome

Endocrine Tumors


Ewing Sarcoma

Fanconi's Anemia

Germ Cell Tumors

Hemophagocytic Lymphohistiocytosis

Hemophilia A

Hemophilia B


Hereditary Spherocytosis

Hodgkin's Disease

I-131 MIBG (Metaiodobenzylguadine)

Immune Thrombocytopenc Purpura


Juvenile Myelomonocytic Leukemia

Kostmann Syndrome

Langerhans' Cell Histiocytosis

Lumbar Puncture


Myelodysplastic Syndromes


Neurocutaneous Syndrome


Non-Hodgkin Lymphomas

Optic Glioma


Paroxysmal Nocturnal Hemoglobinuria

Pediatric Bone Marrow Transplant

Pediatric Cancer

Pediatric Sickle Cell Disease



Shwachman-Diamond Syndrome

Sturge-Weber Syndrome

Thalassemia Syndromes


Thyroid Tumors

Tuberous Sclerosis

Vascular malformations

Von Willebrand Disease

VonHippel-Lindau Disease


American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map
American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatric Hematology-Oncology
Fellowship Children's Hospital and Medical Center, Seattle, WA
Residency Children's Hospital of Los Angeles, Los Angeles, CA
Internship Children's Hospital of Los Angeles, Los Angeles, CA
Medical School New York Medical College, New York, NY

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. De Santes' research interests are focused on the utilization of natural killer (NK) cells to treat a wide variety of pediatric malignancies and developing novel stem cell transplant protocols for children with recurrent leukemia and high-risk solid tumors. He also is establishing more effective ways to utilize I-131 MIBG therapy for children with neuroblastoma.

PubMed Articles
Dorsey MJ Wright NAM Chaimowitz NS Dávila Saldaña BJ Miller H Keller MD Thakar MS Shah AJ Abu-Arja R Andolina J Aquino V Barnum JL Bednarski JJ Bhatia M Bonilla FA Butte MJ Bunin NJ Chandra S Chaudhury S Chen K Chong H Cuvelier GDE Dalal J DeFelice ML DeSantes KB Forbes LR Gillio A Goldman F Joshi AY Kapoor N Knutsen AP Kobrynski L Lieberman JA Leiding JW Oshrine B Patel KP Prockop S Quigg TC Quinones R Schultz KR Seroogy C Shyr D Siegel S Smith AR Torgerson TR Vander Lugt MT Yu LC Cowan MJ Buckley RH Dvorak CC Griffith LM Haddad E Kohn DB Logan B Notarangelo LD Pai SY Puck J Pulsipher MA Heimall J Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers. J Clin Immunol . 2020 Oct 2;
[PubMed ID: 33006109]
Damodharan SN Walker KL Forsberg MH McDowell KA Bouchlaka MN Drier DA Sondel PM DeSantes KB Capitini CM Analysis of ex vivo expanded and activated clinical-grade human NK cells after cryopreservation. Cytotherapy . 2020 Aug;22(8):450-457
[PubMed ID: 32536506]
Yu Q Zhong X Chen B Feng Y Ma M Diamond CA Voeller JS Kim M DeSantes KB Capitini CM Patel NJ Hoover-Regan ML Burke MJ Janko K Puccetti DM Ikonomidou C Li L Isobaric Labeling Strategy Utilizing 4-Plex <i>N</i>,<i>N</i>-Dimethyl Leucine (DiLeu) Tags Reveals Proteomic Changes Induced by Chemotherapy in Cerebrospinal Fluid of Children with B-Cell Acute Lymphoblastic Leukemia. J Proteome Res . 2020 Jul 2;19(7):2606-2616
[PubMed ID: 32396724]
Burroughs LM Petrovic A Brazauskas R Liu X Griffith LM Ochs HD Bleesing JJ Edwards S Dvorak CC Chaudhury S Prockop SE Quinones R Goldman FD Quigg TC Chandrakasan S Smith AR Parikh S Dávila Saldaña BJ Thakar MS Phelan R Shenoy S Forbes LR Martinez C Chellapandian D Shereck E Miller HK Kapoor N Barnum JL Chong H Shyr DC Chen K Abu-Arja R Shah AJ Weinacht KG Moore TB Joshi A DeSantes KB Gillio AP Cuvelier GDE Keller MD Rozmus J Torgerson T Pulsipher MA Haddad E Sullivan KE Logan BR Kohn DB Puck JM Notarangelo LD Pai SY Rawlings DJ Cowan MJ Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report. Blood . 2020 Jun 4;135(23):2094-2105
[PubMed ID: 32268350]
Kim M Rao S Eickhoff JC DeSantes KB Capitini CM A Retrospective Analysis of Antithrombin III Replacement Therapy for the Treatment of Hepatic Sinusoidal Obstruction Syndrome in Children Following Hematopoietic Stem Cell Transplantation. J Pediatr Hematol Oncol . 2020 Mar;42(2):145-148
[PubMed ID: 30676436]
Graul-Conroy A Hoover-Regan M DeSantes KB Sondel PM Callander NS Longo WL Fahl WE Reduction in oral mucositis severity using a topical vasoconstrictor: A case report of three bone marrow transplant patients. Integr Cancer Sci Ther . 2018 Dec;5(6)
[PubMed ID: 31832233]
Haddad E Logan BR Griffith LM Buckley RH Parrott RE Prockop SE Small TN Chaisson J Dvorak CC Murnane M Kapoor N Abdel-Azim H Hanson IC Martinez C Bleesing JJH Chandra S Smith AR Cavanaugh ME Jyonouchi S Sullivan KE Burroughs L Skoda-Smith S Haight AE Tumlin AG Quigg TC Taylor C Dávila Saldaña BJ Keller MD Seroogy CM Desantes KB Petrovic A Leiding JW Shyr DC Decaluwe H Teira P Gillio AP Knutsen AP Moore TB Kletzel M Craddock JA Aquino V Davis JH Yu LC Cuvelier GDE Bednarski JJ Goldman FD Kang EM Shereck E Porteus MH Connelly JA Fleisher TA Malech HL Shearer WT Szabolcs P Thakar MS Vander Lugt MT Heimall J Yin Z Pulsipher MA Pai SY Kohn DB Puck JM Cowan MJ O'Reilly RJ Notarangelo LD SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery. Blood . 2018 Oct 25;132(17):1737-1749
[PubMed ID: 30154114]
McCabe KE Pollock AJ Rehm JL DeSantes KB Curative potential of allogeneic hematopoietic stem cell transplant in type 1 diabetes. Pediatr Diabetes . 2017 Dec;18(8):832-834
[PubMed ID: 27572817]
Wang W Erbe AK DeSantes KB Sondel PM Donor selection for ex vivo-expanded natural killer cells as adoptive cancer immunotherapy. Future Oncol . 2017 May;13(12):1043-1047
[PubMed ID: 28492088]
McDowell KA Hank JA DeSantes KB Capitini CM Otto M Sondel PM NK cell-based immunotherapies in Pediatric Oncology. J Pediatr Hematol Oncol . 2015 Mar;37(2):79-93
[PubMed ID: 25590232]
Capitini CM Otto M DeSantes KB Sondel PM Immunotherapy in pediatric malignancies: current status and future perspectives. Future Oncol . 2014;10(9):1659-78
[PubMed ID: 25145434]
Delgado D Webster DE DeSantes KB Durkin ET Shaaban AF KIR receptor-ligand incompatibility predicts killing of osteosarcoma cell lines by allogeneic NK cells. Pediatr Blood Cancer . 2010 Dec 15;55(7):1300-5
[PubMed ID: 20981688]
Delgado DC Hank JA Kolesar J Lorentzen D Gan J Seo S Kim K Shusterman S Gillies SD Reisfeld RA Yang R Gadbaw B DeSantes KB London WB Seeger RC Maris JM Sondel PM Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res . 2010 Dec 1;70(23):9554-61
[PubMed ID: 20935224]
Shusterman S London WB Gillies SD Hank JA Voss SD Seeger RC Reynolds CP Kimball J Albertini MR Wagner B Gan J Eickhoff J DeSantes KB Cohn SL Hecht T Gadbaw B Reisfeld RA Maris JM Sondel PM Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II study. J Clin Oncol . 2010 Nov 20;28(33):4969-75
[PubMed ID: 20921469]
Bunin NJ Davies SM Aplenc R Camitta BM DeSantes KB Goyal RK Kapoor N Kernan NA Rosenthal J Smith FO Eapen M Unrelated donor bone marrow transplantation for children with acute myeloid leukemia beyond first remission or refractory to chemotherapy. J Clin Oncol . 2008 Sep 10;26(26):4326-32
[PubMed ID: 18779619]
Gowans LK Bentz ML DeSantes KB Thompson KJ Successful treatment of an infant with constitutional chromosomal abnormality and hemangiopericytoma with chemotherapy alone. J Pediatr Hematol Oncol . 2007 Jun;29(6):409-11
[PubMed ID: 17551404]
Ramadan M Whalen B De Santes K Hyperexcitable Blink Reflex Preceding the Diagnosis of Neuroblastoma. J Pediatr Hematol Oncol . 2004 Oct;26(10):665-667
[PubMed ID: 27811609]
Ramadan M Whalen B De Santes K Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma. J Pediatr Hematol Oncol . 2004 Oct;26(10):665-7
[PubMed ID: 15454839]
Emile JF Geissmann F Martin OC Radford-Weiss I Lepelletier Y Heymer B Espanol T de Santes KB Bertrand Y Brousse N Casanova JL Fischer A Langerhans cell deficiency in reticular dysgenesis. Blood . 2000 Jul 1;96(1):58-62
[PubMed ID: 10891430]
O'Marcaigh AS Puck JM Pepper AE De Santes K Cowan MJ Maternal mosaicism for a novel interleukin-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency in a Navajo kindred. J Clin Immunol . 1997 Jan;17(1):29-33
[PubMed ID: 9049783]