Charles K. Stone, MD, FACC close
Charles K. Stone, MD, FACC

New Patients

Contact the Welcome Center for help choosing a new primary care doctor.

For Referring Physicians

How to refer a patient

Charles K. Stone, MD, FACC Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Stone is board certified in Internal Medicine and Cardiovascular Disease. He joined the faculty at the University of Wisconsin in 1988 as director of Nuclear Cardiology. His clinical activities include supervising and interpreting treadmill and pharmacologic stress tests, interpreting cardiac PET scans, implementing novel imaging protocols and serving as clinical liaison for the Nuclear Cardiology section, which provides a broad base of nuclear imaging techniques. In 2003, he was appointed director of Cardiology Outreach, overseeing outreach clinics at regional hospitals in southern and central Wisconsin. His special interests are noninvasive imaging of heart disease and regional distribution of specialty care.



Arbor Gate Heart Clinic
(608) 287-2434 | | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Cardiovascular Disease
Fellowship University of Rochester Medical Center, Rochester, NY
Residency University of Michigan Medical Center, Ann Arbor, MI
Internship University of Michigan Medical Center, Ann Arbor, MI
Medical School Cornell University Medical College, New York, NY

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Stone is active in studies of myocardial metabolism and perfusion using PET and gamma camera agents. His research awards include the National Research Service Award and the American Heart Association-Wisconsin Affiliate David McClain Award.

PubMed Articles
Zammit MD Tudorascu DL Laymon CM Hartley SL Zaman SH Ances BM Johnson SC Stone CK Mathis CA Klunk WE Cohen AD Handen BL Christian BT PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome. Neuroimage . 2021 Mar;228:117728
[PubMed ID: 33421595]
Zammit MD Laymon CM Tudorascu DL Hartley SL Piro-Gambetti B Johnson SC Stone CK Mathis CA Zaman SH Klunk WE Handen BL Cohen AD Christian BT Patterns of glucose hypometabolism in Down syndrome resemble sporadic Alzheimer's disease except for the putamen. Alzheimers Dement (Amst) . 2020;12(1):e12138
[PubMed ID: 33490360]
Koscik RL Betthauser TJ Jonaitis EM Allison SL Clark LR Hermann BP Cody KA Engle JW Barnhart TE Stone CK Chin NA Carlsson CM Asthana S Christian BT Johnson SC Amyloid duration is associated with preclinical cognitive decline and tau PET. Alzheimers Dement (Amst) . 2020;12(1):e12007
[PubMed ID: 32211502]
Betthauser TJ Koscik RL Jonaitis EM Allison SL Cody KA Erickson CM Rowley HA Stone CK Mueller KD Clark LR Carlsson CM Chin NA Asthana S Christian BT Johnson SC Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age. Brain . 2020 Jan 1;143(1):320-335
[PubMed ID: 31886494]
Lao PJ Handen BL Betthauser TJ Cody KA Cohen AD Tudorascu DL Stone CK Price JC Johnson SC Klunk WE Christian BT Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation. Brain Imaging Behav . 2019 Apr;13(2):345-353
[PubMed ID: 29752653]
Betthauser TJ Cody KA Zammit MD Murali D Converse AK Barnhart TE Stone CK Rowley HA Johnson SC Christian BT In Vivo Characterization and Quantification of Neurofibrillary Tau PET Radioligand <sup>18</sup>F-MK-6240 in Humans from Alzheimer Disease Dementia to Young Controls. J Nucl Med . 2019 Jan;60(1):93-99
[PubMed ID: 29777006]
Lao PJ Handen BL Betthauser TJ Mihaila I Hartley SL Cohen AD Tudorascu DL Bulova PD Lopresti BJ Tumuluru RV Murali D Mathis CA Barnhart TE Stone CK Price JC Devenny DA Johnson SC Klunk WE Christian BT Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome. J Alzheimers Dis . 2018;61(2):631-644
[PubMed ID: 29254096]
Betthauser TJ Hillmer AT Lao PJ Ehlerding E Mukherjee J Stone CK Christian BT Human biodistribution and dosimetry of [<sup>18</sup>F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer. Nucl Med Biol . 2017 Dec;55:7-11
[PubMed ID: 28963927]
Lao PJ Betthauser TJ Tudorascu DL Barnhart TE Hillmer AT Stone CK Mukherjee J Christian BT [<sup>18</sup> F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors. Synapse . 2017 Aug;71(8)
[PubMed ID: 28420041]
Betthauser TJ Lao PJ Murali D Barnhart TE Furumoto S Okamura N Stone CK Johnson SC Christian BT In Vivo Comparison of Tau Radioligands <sup>18</sup>F-THK-5351 and <sup>18</sup>F-THK-5317. J Nucl Med . 2017 Jun;58(6):996-1002
[PubMed ID: 27856627]
Lao PJ Handen BL Betthauser TJ Mihaila I Hartley SL Cohen AD Tudorascu DL Bulova PD Lopresti BJ Tumuluru RV Murali D Mathis CA Barnhart TE Stone CK Price JC Devenny DA Mailick MR Klunk WE Johnson SC Christian BT Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population. Alzheimers Dement (Amst) . 2017;9:1-9
[PubMed ID: 28603769]
Gallagher CL Bell B Palotti M Oh J Christian BT Okonkwo O Sojkova J Buyan-Dent L Nickles RJ Harding SJ Stone CK Johnson SC Holden JE Anterior cingulate dopamine turnover and behavior change in Parkinson's disease. Brain Imaging Behav . 2015 Dec;9(4):821-7
[PubMed ID: 25511521]
Hillmer AT Wooten DW Bajwa AK Higgins AT Lao PJ Betthauser TJ Barnhart TE Rowley HA Stone CK Johnson SC Mukherjee J Christian BT First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors. J Nucl Med . 2014 Dec;55(12):1973-9
[PubMed ID: 25453045]
Li CT Palotti M Holden JE Oh J Okonkwo O Christian BT Bendlin BB Buyan-Dent L Harding SJ Stone CK DeJesus OT Nickles RJ Gallagher CL A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson's disease. Synapse . 2014 Aug;68(8):325-31
[PubMed ID: 24710997]
Gallagher CL Christian BT Holden JE Dejesus OT Nickles RJ Buyan-Dent L Bendlin BB Harding SJ Stone CK Mueller B Johnson SC A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease. Mov Disord . 2011 Sep;26(11):2032-8
[PubMed ID: 21638324]
Ferrarelli F Haraldsson HM Barnhart TE Roberts AD Oakes TR Massimini M Stone CK Kalin NH Tononi G A [17F]-fluoromethane PET/TMS study of effective connectivity. Brain Res Bull . 2004 Aug 30;64(2):103-13
[PubMed ID: 15342097]
Chu WW Dieter RS Stone CK A review of clinically relevant cardiac biochemical markers. WMJ . 2002;101(3):40-8
[PubMed ID: 12109201]