estropipate

Pronunciation: ES troe PIP ate

Brand: Ogen 0.625, Ogen 1.25, Ogen 2.5

Estropipate 0.75 mg-BAR

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round, yellow, imprinted with barr, 555 727

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Estropipate 0.75 mg-MYL

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round, yellow, imprinted with M E7

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Estropipate 0.75 mg-WAT

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round, yellow, imprinted with WATSON 414

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Estropipate 1.5 mg-BAR

slide 4 of 12, Estropipate 1.5 mg-BAR,

round, peach, imprinted with barr, 555 728

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Estropipate 1.5 mg-MYL

slide 5 of 12, Estropipate 1.5 mg-MYL,

round, peach, imprinted with M E8

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Estropipate 1.5 mg-WAT

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round, orange, imprinted with WATSON, 415

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Estropipate 3 mg-BAR

slide 7 of 12, Estropipate 3 mg-BAR,

round, blue, imprinted with barr, 555 729

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Ogen 0.625 mg-PFI

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oval, yellow, imprinted with U 3772

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Ogen 1.25 mg-PFI

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oval, orange, imprinted with U 1773

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Ogen 2.5 mg-PFI

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oval, blue, imprinted with U 3774

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Ortho-Est 0.75 mg

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diamond, white, imprinted with ORTHO 1801

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Ortho-Est 1.5 mg

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diamond, lavender, imprinted with ORTHO 1800

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What is the most important information I should know about estropipate?

You should not use estropipate if you have: undiagnosed vaginal bleeding, liver disease, if you have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Estropipate may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, or heart attack. Estropipate should not be used to prevent heart disease, stroke, or dementia. Long-term use may increase your risk of cancer of the breast, uterus, or ovaries.

What is estropipate?

Estropipate is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Estropipate is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Estropipate is also used to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.

Estropipate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking estropipate?

You should not use estropipate if you are allergic to it, or if you have:

  • unusual vaginal bleeding that has not been checked by a doctor;
  • liver disease;
  • a history of heart attack, stroke, or blood clot; or
  • a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.

Do not use estropipate if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Using estropipate can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Estropipate should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

To make sure estropipate is safe for you, tell your doctor if you have ever had:

  • a hysterectomy;
  • heart disease;
  • liver problems, or jaundice caused by pregnancy or taking hormones;
  • a thyroid disorder;
  • gallbladder disease;
  • kidney disease;
  • asthma;
  • epilepsy or other seizure disorder;
  • migraine headaches;
  • lupus;
  • endometriosis or uterine fibroid tumors;
  • high levels of calcium in your blood; or
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Long-term use of estropipate may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.

Estropipate lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding.

How should I use estropipate?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Estropipate may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to help lower this risk. Report any unusual vaginal bleeding right away.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estropipate.

If you need major surgery with long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estropipate.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using estropipate?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estropipate.

Grapefruit and grapefruit juice may interact with estropipate and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

What are the possible side effects of estropipate?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • heart attack symptoms --chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • signs of a stroke --sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot --sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • swelling or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes);
  • memory problems, confusion, unusual behavior;
  • unusual vaginal bleeding, pelvic pain;
  • a lump in your breast; or
  • high levels of calcium in your blood --nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common side effects may include:

  • headache;
  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding;
  • bloating, stomach cramps, nausea, vomiting;
  • breast pain;
  • thinning scalp hair; or
  • fluid retention (swelling, rapid weight gain).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect estropipate?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with estropipate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about estropipate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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