Hallermann Streiff Syndrome
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Hallermann Streiff Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms Back to top
- Francois dyscephaly syndrome
- Hallermann-Streiff-Francois syndrome
- Oculomandibulodyscephaly with hypotrichosis
- Oculomandibulofacial syndrome
Disorder Subdivisions Back to top
General Discussion Back to top
Hallermann-Streiff syndrome was first described in the medical literature in 1893. The disorder was named for two investigators who later independently reported cases of the syndrome (Hallermann W, 1948; Streiff EB, 1950), recognizing it as a distinct disease entity.
Hallermann-Streiff syndrome is a rare genetic disorder that is primarily characterized by distinctive malformations of the skull and facial (craniofacial) region; sparse hair (hypotrichosis); eye (ocular) abnormalities; dental defects; degenerative skin changes (atrophy), particularly in the scalp and nasal regions; and/or short stature (i.e., dwarfism). Characteristic craniofacial features include a short, broad head (brachycephaly) with an unusually prominent forehead and/or sides of the skull (frontal and/or parietal bossing); a small, underdeveloped lower jaw (hypoplastic mandible); a narrow, highly arched roof of the mouth (palate); and a thin, pinched, tapering nose. Many affected individuals also have clouding of the lenses of the eyes at birth (congenital cataracts); unusually small eyes (microphthalmia); and/or other ocular abnormalities. Dental defects may include the presence of certain teeth at birth (natal teeth) and absence (hypodontia or partial adontia), malformation, and/or improper alignment of teeth. In almost all cases, Hallermann-Streiff syndrome has appeared to occur randomly for unknown reasons (sporadically) and may be the result of a new change to genetic material (mutation).
Resources Back to top
National Foundation for Ectodermal Dysplasias
410 East Main Street
Mascoutah, IL 62258-0114
FACES: The National Craniofacial Association
PO Box 11082
Chattanooga, TN 37401
National Association for Parents of Children with Visual Impairments (NAPVI)
P.O. Box 317
Watertown, MA 02272-0317
Little People of America, Inc.
250 El Camino Real
Tustin, CA 92780
NIH/National Eye Institute
31 Center Dr
Bethesda, MD 20892-2510
Institute for Families
4650 Sunset Blvd
Los Angeles, CA 90027
Coalition for Heritable Disorders of Connective Tissue (CHDCT)
4301 Connecticut Avenue, NW Suite 404
Washington, DC 20008
Craniofacial Foundation of America
975 East Third Street
Chattanooga, TN 37403
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
PO Box 241956
Los Angeles, CA 90024
Hallerman-Streiff Syndrome Resource
3524 Blenheim Road
Phoenix, MD 21131
For a Complete Report Back to top
This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email email@example.com
Last Updated: 11/12/2008
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