Brugada Syndrome

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Brugada Syndrome is not the name you expected.

Disorder Subdivisions

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General Discussion


Brugada syndrome is a rare inherited cardiovascular disorder characterized by disturbances affecting the electrical system of the heart. The main symptom is irregular heartbeats and, without treatment, may potentially result in sudden death. Recent reports suggest that Brugada syndrome could be responsible up to 20% of sudden death in patients with structurally normal hearts. The clinical phenotype manifests in adulthood, and it is more frequent in males. Frequently, sudden death can be the first manifestation of the disease. Brugada syndrome is a genetic disease and follows autosomal dominant inheritance. Currently, the prevalence of Brugada syndrome is estimated at 5 in 10,000 people.
The normal heart has four chambers. The two upper chambers are known as the atria and the two lower chambers are known as the ventricles. Electrical impulses cause the heart to beat. In individuals with Brugada syndrome, the electrical impulses between the ventricles become uncoordinated (ventricular fibrillation) resulting in decreased blood flow. Decreased blood flow to the brain and heart may result in fainting or sudden death.

Brugada syndrome is named by the Spanish cardiologists Pedro Brugada and Josep Brugada who reported it as a distinct clinical syndrome in 1992. The genetic basis of Brugada syndrome was established by Ramon Brugada in 1998.

Supporting Organizations

American Heart Association

7272 Greenville Avenue
Dallas, TX 75231
Tel: (214)784-7212
Fax: (214)784-1307
Tel: (800)242-8721

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311

Ramon Brugada Senior Foundation

Pic de Peguera 15
Girona, 17003
Tel: 34 972 183366
Fax: 34 972 183367

Sudden Arrhythmia Death Syndromes Foundation

4527 S 2300 E
Suite 104
Salt Lake City, UT 84117-4448
Tel: 801-272-3023
Fax: (801)531-0945
Tel: (800)786-7723

For a Complete Report

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Last Updated:  4/4/2016
Copyright  2016 National Organization for Rare Disorders, Inc.