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American Family Children's Hospital


Pronunciation: sull fa DYE ah zeen

What is the most important information I should know about sulfadiazine?

Multum nopreg

Do not use sulfadiazine during late pregnancy, just before you deliver.

Multum nobrfeed

Do not use if you are breast-feeding a baby.

What are sulfadiazine?

Sulfadiazine is an antibiotic that fights bacteria.

Sulfadiazine is used to treat many different types of infection, such as urinary tract infections, ear infections, meningitis, malaria, toxoplasmosis, and others.

Sulfadiazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking sulfadiazine?

Multum donot

You should not use this medicine if you are allergic to any sulfa drug.

Multum nopreg

Do not use sulfadiazine during late pregnancy, just before you deliver.

Multum nobrfeed

Do not use if you are breast-feeding a baby.

Multum nochild

Do not give sulfadiazine to a child younger than 2 months old without a doctor's advice.

To make sure sulfadiazine is safe for you, tell your doctor if you have:

  • kidney disease;
  • liver disease;
  • asthma, severe allergies; or
  • a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Multum nopreg

FDA pregnancy category C. It is not known whether sulfadiazine will be harmful to an unborn baby. Sulfadiazine can cause severe jaundice that could lead to brain damage in your newborn if you take this medicine just before childbirth. Tell your doctor if you are pregnant.

Multum nobrfeed

Sulfadiazine can pass into breast milk and may harm a nursing baby. Do not breast-feed while using sulfadiazine.

How should I take sulfadiazine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Multum water

Take this medicine with a full glass (8 ounces) of water. Drink plenty of liquids while you are taking sulfadiazine to keep your kidneys working properly.

Take your doses at regular intervals to keep a steady amount of the drug in your body at all times.

Multum donot

Do not use sulfadiazine to treat any condition that has not been checked by your doctor.

Do not share this medicine with another person, even if they have the same symptoms you have.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Sulfadiazine will not treat a viral infection such as the flu or a common cold.

Multum calldoc

Call your doctor if your symptoms do not improve, or if they get worse while using sulfadiazine.

While using sulfadiazine, you may need frequent blood and urine tests.

Multum rt

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking sulfadiazine?

Multum nosun

Avoid exposure to sunlight or tanning beds. Sulfadiazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of sulfadiazine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum calldoc

Call your doctor at once if you have:

  • sudden weakness or ill feeling, fever, chills, sore throat, swollen glands, joint pain, mouth sores, red or swollen gums, trouble swallowing;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • increased or decreased urinating, pain in your side or lower back;
  • hallucinations, seizure (convulsions);
  • liver problems --nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • severe skin reaction --swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • nausea, vomiting, diarrhea, stomach pain, loss of appetite;
  • headache, ringing in your ears;
  • dizziness, spinning sensation, loss of balance or coordination;
  • numbness, tingling, or burning pain in your hands or feet;
  • sleep problems (insomnia); or
  • depressed mood.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sulfadiazine?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with sulfadiazine, especially:

  • methotrexate; or
  • a blood thinner (warfarin, Coumadin, Jantoven).

This list is not complete. Other drugs may interact with sulfadiazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about sulfadiazine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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