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promethazine (injection)

Pronunciation: pro METH a zeen

Brand: Adgan, Anergan 50, Phenergan

What is the most important information I should know about promethazine injection?

Multum emt

Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Multum donot

You should not receive this medication if you are allergic to promethazine or to similar medicines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).

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This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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Tell your doctor right away if you have serious side effects while receiving promethazine injection, such as slow, shallow breathing, feeling light-headed, fainting, severe burning or skin irritation where the injection was given, confusion, hallucinations, muscle twitching, or muscle movements you cannot control.

What is promethazine injection?

Promethazine is in a group of drugs called phenothiazines (feen-oh-THYE-oh-zeens).

Promethazine is used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures.

Promethazine injection is usually given when a person cannot take the medication orally (by mouth).

Promethazine injection may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before I receive promethazine injection?

Multum donot

You should not use this medication if you are allergic to promethazine or to similar medicines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).

To make sure you can safely use promethazine, tell your doctor if you have any of these other conditions:

  • asthma, sleep apnea, or other breathing problems;
  • epilepsy or other seizure disorder;
  • a weak immune system (bone marrow depression);
  • glaucoma;
  • enlarged prostate or problems with urination;
  • stomach ulcer or obstruction;
  • heart disease or high blood pressure;
  • liver disease;
  • adrenal gland tumor (pheochromocytoma);
  • low levels of calcium in your blood (hypocalcemia); or
  • if you have ever had a serious side effect while using promethazine or any other phenothiazine.
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FDA pregnancy category C. It is not known whether promethazine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

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It is not known whether promethazine passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is promethazine injection given?

Promethazine is given as an injection deep into a muscle. You will receive this injection in a clinic or hospital setting. This medication is usually given every 2 to 4 hours depending on the condition it is used for.

Promethazine injection is usually given for only a short time until no longer needed or until you can take promethazine by mouth.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you have recently received promethazine injection.

What happens if I miss a dose?

Since promethazine injection is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include slow or shallow breathing, extreme drowsiness or weakness, feeling light-headed, or fainting.

What should I avoid while receiving promethazine injection?

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This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

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Avoid exposure to sunlight or tanning beds. Promethazine injection can make your skin more sensitive to sunlight and sunburn may result.

What are the possible side effects of promethazine injection?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have a serious side effect such as:

  • twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
  • tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
  • feeling restless, jittery, or agitated;
  • slow, shallow breathing, feeling like you might pass out;
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
  • pain, burning, severe irritation, muscle weakness, or skin changes where the injection was given;
  • confusion, hallucinations, hysteria, seizure (black-out or convulsions);
  • fast or slow heartbeats;
  • fever, chills, body aches, flu symptoms;
  • urinating less than usual or not at all;
  • easy bruising or bleeding, unusual weakness; or
  • jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • drowsiness, dizziness, tired feeling;
  • ringing in your ears;
  • problems with balance or coordination;
  • blurred vision;
  • feeling nervous or shaky;
  • sleep problems (insomnia);
  • skin rash or itching; or
  • dry mouth, stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect promethazine injection?

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Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can interact with promethazine and cause medical problems or increase side effects. Tell your doctor if you regularly use any of these medicines.

Tell your doctor about all other medicines you use, especially:

  • lithium (Eskalith, Lithobid);
  • atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
  • blood pressure medication such as guanadrel (Hylorel), propranolol (Inderal), and others;
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
  • bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others;
  • an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or
  • medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma); or
  • medicine to treat stomach ulcer or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), mepenzolate (Cantil), or propantheline (Pro-Banthine).

This list is not complete and there are many other medicines that can interact with promethazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your doctor or pharmacist has information about promethazine injection.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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