Skip to Content
UW Health SMPH
American Family Children's Hospital
SHARE TEXT

oprelvekin (injection)

Pronunciation: oh PERL ve kin

Brand: Neumega

What is the most important information I should know about oprelvekin?

Multum emt

Stop using oprelvekin and get emergency medical help if you have any of these signs of an allergic reaction: fever, rash, shortness of breath, chest pain, wheezing, confusion, fainting, hives, or swelling of your face, lips, tongue, or throat.

Once you have had an allergic reaction to oprelvekin, you must never use it again.

Multum emt

Other serious side effects of oprelvekin include swelling or rapid weight gain, chest pain, uneven heartbeats, sudden numbness or weakness, confusion, problems with speech or balance, and sudden vision loss or pain behind your eyes. Call your doctor at once if you have any of these side effects.

What is oprelvekin?

Oprelvekin is a protein that stimulates production of platelets in the blood. Platelets are important for proper clotting of the blood and for wound healing.

Oprelvekin is used to prevent platelets from becoming dangerously low in certain people receiving chemotherapy that can result in bone marrow suppression or the need for blood platelet transfusions.

Oprelvekin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using oprelvekin?

Multum donot

You should not use oprelvekin if you are allergic to it.

To make sure oprelvekin is safe for you, tell your doctor if you have:

  • congestive heart failure;
  • heart rhythm disorder;
  • a buildup of fluid around your lungs (also called pleural effusion);
  • a history of heart disease or stroke;
  • a history of fluid around your liver or heart;
  • a seizure disorder;
  • kidney disease;
  • low levels of potassium in your blood; or
  • if you take a diuretic or "water pill."
Multum nopreg

FDA pregnancy category C. It is not known whether oprelvekin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

Multum nobrfeed

It is not known whether oprelvekin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I use oprelvekin?

Oprelvekin is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not understand how to give the injection and properly dispose of used needles and syringes.

Treatment with oprelvekin is usually started 6 to 24 hours after chemotherapy is completed. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Oprelvekin is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Do not shake the medication bottle or you may ruin the medicine. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use a different place on your stomach, thigh, hip, or upper arm each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Multum donot

It may take up to 21 days of using this medicine before your platelets increase. For best results, keep using the medication as directed.

While using oprelvekin, you may need frequent blood tests.

Multum refig

Store unused oprelvekin vials and diluent syringes in the refrigerator. Do not freeze.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of oprelvekin.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using oprelvekin?

Avoid making any changes in your diet while using this medication. Oprelvekin can cause fluid retention and swelling. Your doctor may recommend a low-salt diet to prevent this condition.

What are the possible side effects of oprelvekin?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction:

  • hives, rash, itching;
  • fever, flushing (warmth, redness, or tingly feeling);
  • wheezing, difficult breathing, chest pain, tightness in your throat;
  • speech problems, confusion, drowsiness, changes in your mental status, feeling like you might pass out; or
  • swelling of your face, lips, tongue, or throat.

An allergic reaction may occur even if you have received oprelvekin in the past without a reaction. Once you have had an allergic reaction to oprelvekin, you must never use it again.

Multum calldoc

Stop using oprelvekin and call your doctor at once if you have:

  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • pounding heartbeats or fluttering in your chest;
  • pain in your chest, on your left side, or behind your breastbone;
  • pain when you breathe, rapid heart rate, feeling short of breath (especially when lying down), feeling weak or tired;
  • anxiety, sweating, pale skin, gasping for breath, cough with foamy mucus;
  • fever, chills, cold or flu symptoms, cough with yellow or green mucus, new or worsening cough, trouble breathing;
  • sudden vision loss, headache or pain behind your eyes with vomiting; or
  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • slight swelling in your hands or feet;
  • eye redness;
  • breathing problems;
  • blurred vision;
  • swelling or bruising where the medicine was injected; or
  • pale skin, trouble concentrating.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect oprelvekin?

Other drugs may interact with oprelvekin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about oprelvekin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 2.01. Revision date: 3/16/2014.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by clicking on this link.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.