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brentuximab vedotin

Pronunciation: bren TUX i mab ve DOE tin

Brand: Adcetris

What is the most important information I should know about brentuximab vedotin?

Multum donot

You should not receive brentuximab vedotin if you are allergic to it, or if you are also receiving another cancer medicine called bleomycin (Blenoxane).

Multum emt

Some people receiving a brentuximab vedotin injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel nauseated, itchy, or if you have a fever, chills, cough, or trouble breathing during the injection. Infusion reactions often occur within the first 24 hours after the start of your brentuximab vedotin infusion.

Multum emt

Brentuximab vedotin can lower blood cells that help your body fight infections and help your blood clot. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection.

While using brentuximab vedotin, you may need frequent blood tests at your doctor's office.

Multum donot

Brentuximab vedotin may cause a serious viral infection of the brain that can lead to disability or death. Call your doctor right away if you notice any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

What is brentuximab vedotin?

Brentuximab vedotin is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Brentuximab vedotin is used to treat Hodgkin's lymphoma or anaplastic large cell lymphoma.

Brentuximab vedotin is given after a stem cell transplant or other cancer medications have been tried without successful treatment.

Brentuximab vedotin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving brentuximab vedotin?

Multum donot

You should not receive brentuximab vedotin if you are allergic to it, or if you are also receiving another cancer medicine called bleomycin (Blenoxane).

To make sure you can safely use brentuximab vedotin, tell your doctor if you have any of these other conditions:

  • liver disease;
  • kidney disease;
  • systemic lupus erythematosus (SLE);
  • lung disease or a breathing disorder;
  • a weak immune system; or
  • if you have used certain arthritis medicines in the past that were not effective, including adalimumab (Humira), certolizumab (Cimzia), golimumab (Simponi), etanercept (Enbrel), or infliximab (Remicade).
Multum nopreg

FDA pregnancy category D. Do not receive brentuximab vedotin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Multum nobrfeed

It is not known whether brentuximab vedotin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using brentuximab vedotin.

How is brentuximab vedotin given?

Brentuximab vedotin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Before you receive brentuximab vedotin, you may be given other medications to prevent certain side effects that brentuximab vedotin can cause.

Brentuximab vedotin is usually given once every 3 weeks for up to 16 treatment cycles. Follow your doctor's dosing instructions very carefully.

While using brentuximab vedotin, you may need frequent blood tests at your doctor's office.

Brentuximab vedotin can lower blood cells that help your body fight infections and help your blood clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.

Multum emt

If you need surgery, tell the surgeon ahead of time that you are using brentuximab vedotin.

What happens if I miss a dose?

Call your doctor if you miss an appointment for your brentuximab vedotin injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while receiving brentuximab vedotin?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of brentuximab vedotin?

Some people receiving a brentuximab vedotin injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel nauseated, itchy, or if you have a fever, chills, cough, or trouble breathing during the infusion. Infusion reactions often occur within the first 24 hours after the start of your brentuximab vedotin infusion.

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Brentuximab vedotin increases the risk of a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have symptoms such as a change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

Multum emt

Call your doctor at once if you have any of these other serious side effects, even if they occur several months after you receive brentuximab vedotin, or after your treatment ends.

  • numbness, weakness, burning pain, tingly feeling, or loss of feeling in your arms or legs;
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • lower back pain, blood in your urine;
  • pain or burning when you urinate, urinating less than usual or not at all;
  • numbness or tingling around your mouth;
  • muscle weakness, tightness, or contraction, overactive reflexes;
  • fast or slow heart rate, weak pulse, feeling short of breath, confusion, fainting; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • tired feeling;
  • stomach pain, nausea, vomiting;
  • diarrhea, constipation, weight loss;
  • swelling in your hands or feet;
  • mild rash or itching;
  • dry skin, hair loss;
  • headache, dizziness, anxiety;
  • muscle spasm, muscle or joint pain; or
  • night sweats, sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect brentuximab vedotin?

Tell your doctor about all medications you use, and those you start or stop using during your treatment with brentuximab vedotin, especially:

  • conivaptan (Vaprisol);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • nefazodone;
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);
  • antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
  • heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G); or
  • HIV/AIDS medicine such as atazanavir (Reyataz), boceprevir (Victrelis), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), saquinavir (Invirase), or telaprevir (Incivek).

This list is not complete. Other drugs may interact with brentuximab vedotin, including prescription, over-the-counter, vitamin, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your doctor or pharmacist can provide more information about brentuximab vedotin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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