Toxicology | Drug Screen, GCMS, Urine

UWHC Lab Test Details
Test NameDrug Screen, GCMS, Urine
Test Code(s)HCTUPNL
CPT Code(s)80307 or G0659
MethodologyGas Chromatography/Mass Spectrometry
Testing SiteUniversity Hospital
Days PerformedMon-Fri, dayshift.
In-Lab Turnaround Time1 - 3 days.
Collection Requirements
SpecimenRandom urine
Collection Container
Collection ContainerSterile screw cap container
Collection Instructions

Drugs suspected and known medications should be indicated. The laboratory strongly favors direct communication between the primary physician and the laboratory. Since the drug screen is a search for the presence of an unknown drug, any drug-related patient history communicated to the laboratory will give the analyst a point of direction in the testing of the sample and help expedite return of results.

Collection Volume25 mL
Specimen Processing Requirements
Stability
Stability Ambient

3 days

Stability Refrigerated

7 days

Stability Frozen

1 year

Sample AnalyzedUrine aliquot
Testing Volume10 mL
Pediatric Testing Volume7 mL
Specimen Transport

Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.

Interpretation
Additional Information

The Comprehensive Drug Screen screens for the presence of over 100 drug substances and drug metabolites in human urine by GC/MS. Report consists of immunoassay screening results and a list of drugs detected and definitively identified by GC/MS. Certain commonly encountered drugs such as morphine, hydromorphone, alprazolam, triazolam, and oxazepam may not be detected by GC/MS because they exhibit poor chromatographic properties. However, these drugs will give presumptive positive immunoassay screening results for the benzodiazepine or opiate classes. Certain toxic substances such as LSD, cannabinoids, alcohols, insecticides, cyanide, carbon monoxide, salicylic acid, water soluble drugs such as diuretics and many other chemicals and drugs are not detected by this procedure. 

 

This is a comprehensive test which simultaneously screens for and confirms the presence of the following drugs:

ANALGESICS: antipyrine, ibuprofen, naproxen, orphenadrine, phenylbutazone,  tramadol

ANTIDEPRESSANTS: amitriptyline, bupropion, clomipramine, desipramine, doxepin, fluoxetine, imipramine, maprotiline, mirtazepine, nortriptyline, paroxetine, sertraline, trazodone, venlafaxine

ANTIEPILEPTICS: carbamazepine, felbamate, gabapentin, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide

ANTIHISTAMINES: chlorpheniramine, diphenhydramine, doxylamine, pheniramine, pyrilamine, tripelennamine

ANTIPSYCHOTICS: chlorpromazine, clozapine, olanzapine, quetiapine, thioridazine

NARCOTICS: codeine, dihydrocodeine, fentanyl, hydrocodone, levorphanol, meperidine, methadone, oxycodone, pentazocine, propoxyphene

SEDATIVES/HYPNOTICS: amobarbital, barbital, butabarbital, butalbital, carisoprodal, chlordiazepoxide, diazepam, ethchlorvynol, flurazepam, meprobamate, metaxalone, methaqualone, midazolam, nordiazepam, pentobarbital, propofol, secobarbital, temazepam, thiopental, zolpidem

SYMPATHOMIMETICS: amphetamine, cathinone, cyclopentamine, ephedrine/pseudoephedrine, methamphetamine, methcathinone, 4-methylaminorex, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxyethylamphetamine, 3,4-methylenedioxymethamphetamine, phentermine

MISCELLANEOUS: amantadine, atropine, cocaine metabolites, cyclobenzaprine, dextromethorphan, diltiazem, disopyramide, fluconazole, lidocaine, phencyclidine, procainamide, propranolol, promethazine, scopolamine, strychnine, theophylline, ticlopidine, trimethoprim, verapamil

 

NOTE: Please call (608) 263-7029 with any questions regarding drugs not on this list.

 

This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.