Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
What is cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC)?
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is a form of chemotherapy used after surgeons perform cytoreductive surgery - removal or reduction of a tumor.
During HIPEC procedures, the surgeons first surgically remove all visible tumors within the abdomen. After all visible tumors have been removed, the heated chemotherapy solution is introduced to the region in surgery and destroys any cancer cells that may still be present.
Candidates for HIPEC Treatment
HIPEC may be used for people suffering from an advanced spread of cancer in the abdomen, with no evidence of cancer outside the abdomen.
Advantages of HIPEC
- Surgeons can use higher doses of chemotherapy
- It is a more powerful form of chemotherapy than the traditional method
- Chemotherapy is applied only to the abdomen, reducing the chance of exposure in other parts of the body and potentially minimizing side effects
- In comparison to traditional chemotherapy delivery, HIPEC allows for higher doses of chemotherapy treatment to the abdominal cavity. Heating the solution (i.e., hyperthermia) also enhances the power of the chemotherapy, improving absorption by tumors and susceptibility of cancer cells to chemotherapy. Furthermore, because the chemotherapy is kept within the abdomen, it minimizes the rest of the body’s exposure to the treatment, which helps reduce some chemotherapy side effects.