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Protocol No. UW18046

Principal Investigator Kuchnia, Adam

Phase N/A

Age Group Adult

Scope Local

Sponsor Type Institutional

Title Muscle Quality: A Future Target for Nutritional Intervention

Objective Malnutrition and loss of muscle in hospitalized patients is bad for their well-being and recovery. The purpose of this research study is to test new techniques for measuring changes in muscle quality, which may be an early sign of malnutrition. If malnutrition can be identified sooner it can help doctors treat patients. Currently, clinicians do not have a simple and convenient way to look at muscle quality. Our goal is to find new ways to detect these changes in aging persons, and persons with disease such as cancer. Our hope is that by looking at disease and age-specific muscle quality, we will change the way nutrition is given to hospital patients, and help us understand the role of nutrition in disease and aging

Treatment
  • Body Measurements
  • Force-measuring Ultrasound (US)
  • Shear Wave Elastography
  • Magnetic Resonance Imaging (MRI)
  • Muscle Biopsy

  • Description Muscle Quality: A Future Target for Nutritional Intervention

    Key Eligibility
    Inclusion for healthy participatants:
  • Healthy, with no known significant medical concerns
  • Age ranges between 25 – 45 years and 55 – 75 years
    Inclusion criteria for cancer participants:
  • Undergoing outpatient systemic therapy treatment for lung cancer
  • Deemed healthy enough to participate by primary Hematologist/Oncologist
    Exclusion criteria for healthy participants:
  • History of previous medical issues, including diabetes, cardiovascular disease, organ transplant, neuromuscular disease, or any medical condition deemed to be significant
  • Pacemakers, aneurysm clips, cochlear implants, prosthetic devices, implanted drug infusion pumps, neurostimulators, bone-growth stimulators, intrauterine contraceptive devices, iron-based metal implants
  • Pregnancy
    Exclusion criteria for cancer participants:
  • Deemed too ill by primary Hematologist/Oncologist
  • History of uncontrolled diabetes mellitus
  • Pacemakers, aneurysm clips, cochlear implants, prosthetic devices, implanted drug infusion pumps, neurostimulators, bone-growth stimulators, intrauterine contraceptive devices, iron-based metal implants
    Further exclusion criteria for all participants:
  • All patients will be screened for metallic implants, including drug infusion pumps and ports, via standard MRI screening procedures. If a patient has such an infusion pump or port, the manufacturer information will be reviewed. If the literature is clear on the safe use of the device in the MRI environment, the patient will be eligible for the study. However, if the infusion device is contraindicated or there is any uncertainty regarding the safety of the infusion device in the MR environment, the patient will be excluded from the study

  • Applicable Disease Sites Lung

    Status Open

    Participating Institutions UW Hospital and Clinics