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Protocol No. UW18000

Principal Investigator Lambert, Paul

Phase N/A

Age Group Adult

Scope Local

Sponsor Type Externally Peer-Reviewed

Title Characterization of the Virome and Microbiome of Normal and Neoplastic Skin of Organ Transplant Recipients

Objective The purpose of this research study is to look at the relationship between cutaneous human papillomaviruses and squamous cell carcinomas in people who either have or have not had an organ transplant. We are doing this research because we would like to address if drugs which works against the body's immune (protective) response, often used in organ transplant patients inclines them to HPV infections versus people who have not taken these drugs. Also, we would like to see if HPV's present in SCC's are teh same as in normal skin.

Treatment NA

Key Eligibility Organ Transplant Subject Inclusion

Over the age of 18 years

Having SCC removed that is visible and palpable with a tumor size of at least 1cm

Have had an organ transplant and been on immunosuppressant treatment for greater than three years.
Organ Transplant Subject Exclusion

Prisoner

Psychiatric inpatients or people who are institutionalized
Immunocompetent Control Subject Inclusion

Over the age of 18 years

Having SCC removed that is visible and palpable with a tumor size of at least 1cm
Immunocompetent Control Subject Exclusion

Has an immunosuppressive disorder such as, but not limited to, HIV infection or autoimmune diseases that require chronic immunosuppressants

Prisoner

Psychiatric inpatients or people who are institutionalized

Applicable Disease Sites Melanoma/Skin cancer

Status Open

Participating Institutions UW Hospital and Clinics; UWCCC 1 South Park