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Protocol No.
UW18000
Principal Investigator
Lambert, Paul
Phase
N/A
Age Group
Adult
Scope
Local
Sponsor Type
Externally Peer-Reviewed
Title
Characterization of the Virome and Microbiome of Normal and Neoplastic Skin of Organ Transplant Recipients
Objective
The purpose of this research study is to look at the relationship between cutaneous human papillomaviruses and squamous cell carcinomas in people who either have or have not had an organ transplant. We are doing this research because we would like to address if drugs which works against the body's immune (protective) response, often used in organ transplant patients inclines them to HPV infections versus people who have not taken these drugs. Also, we would like to see if HPV's present in SCC's are teh same as in normal skin.
Treatment
NA
Key Eligibility
Organ Transplant Subject Inclusion
Over the age of 18 years
Having SCC removed that is visible and palpable with a tumor size of at least 1cm
Have had an organ transplant and been on immunosuppressant treatment for greater than three years.
Organ Transplant Subject Exclusion Prisoner
Psychiatric inpatients or people who are institutionalized
Immunocompetent Control Subject Inclusion Over the age of 18 years
Having SCC removed that is visible and palpable with a tumor size of at least 1cm
Immunocompetent Control Subject Exclusion Has an immunosuppressive disorder such as, but not limited to, HIV infection or autoimmune diseases that require chronic immunosuppressants
Prisoner
Psychiatric inpatients or people who are institutionalized
Organ Transplant Subject Exclusion
Immunocompetent Control Subject Inclusion
Immunocompetent Control Subject Exclusion
Applicable Disease Sites
Melanoma/Skin cancer
Status
Open
Participating Institutions
UW Hospital and Clinics; UWCCC 1 South Park