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Externally Peer-Reviewed; Institutional
Improving Pulmonary Function Following Radiation Therapy
The purpose of this study is to develop radiation plans that will help preserve lung function in healthy tissue surrounding the tumor. We believe that 4DCT scans(4-Dimensional Computed Tomography)can be useful in designing radiation treatment plans that help us avoid healthy normal functioning lung tissue close to lung tumors. Currently 4DCT scans are used to help us determine exactly where the tumor is and how it moves when you breathe. In this study we will also use the 4DCT scans to try to identify high functioning normal lung tissue.
CT is an imaging procedure using special x-ray equipment creating detailed pictures of the area of the body being studied. 4DCT is a scan composed of a large number of CT images that are acquired at different points of the breathing cycle.
Two 4DCT scans will be obtained at the time of your radiation treatment planning visit. We will also collect 4DCT's at the 3, 6 and 12 months post radiation physician visits. Information from the post radiation scans and the pulmonary function testing at these time points will tell us how well we avoided the high functioning lung tissue and how well you breathe after radiation. There will be two groups in this study. Those in group 1 will undergo treatment planning and have their radiation treatment plan be based on the standard of care practice of using the 4DCT scan to help us define the tumor that we should treat. Those in group 2 will undergo treatment planning and have their radiation treatment plan be based on the standard of care practice of using the 4DCT scan to help us define the tumor. In addition, we will use the 4DCT scans to help identify normal functioning lung tissue that we will avoid during radiation therapy.
- Histologic diagnosis of a non-small cell lung cancer or lung metastasis from a solid
- Treatment includes localized radiation therapy with or without chemotherapy
- Not pregnant per radiation oncology standard procedures
- Patients with prior (within last 6 months) or future planned therapeutic surgery for the treatment of
the existing lung cancer will be excluded
- Patients with prior thoracic radiotherapy are excluded
- Patients with severe COPD defined as disease requiring an inpatient stay for respiratory
deterioration within the past 3 months are excluded
- Patients with an oxygen dependence of > 2 L/min continuously throughout the day at baseline are excluded
- Patients with a known underlying collagen vascular disease or intrinsic lung disease are excluded
Applicable Disease Sites
UW Hospital and Clinics