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Pilot Study: Comparison of rpFNA and CNB for Breast Tissue Collection for Chemopreventive Studies
The purpose of the research is to test two standard techniques for breast biopsy to
determine the best way to collect breast tissue for research studies. Scientists use
breast tissue to learn more about breast biology, including how healthy breast tissue is
different from breast cancer, and how these changes happen. It is useful for scientists
to have enough breast tissue from each patient to be able to perform multiple studies at
the same time. For example, in this study, the scientists will use the breast tissue to
study the kinds of immune cells in the breast, as well as the inner structure of the
breast. We think that both the immune system and breast structure can influence
whether a woman is likely to develop breast cancer. If scientists can analyze a patients'
tissue for several factors that give a woman a high risk for breast cancer, they can learn
more about how these factors are interrelated. Understanding as much as possible
about breast cancer is important for designing new preventive and treatment options.
We will therefore compare two breast biopsy methods - Random Periareolar Fine
Needle Aspiration (rpFNA) and Core Needle Biopsy (CNB) - to determine which
method is better for collecting breast tissue for multiple studies in parallel.
If you decide to participate in this research you will be asked to allow the surgeons to
perform the two types of biopsies to the breast during the operation described below.
You will not be asked to do anything for the research study before or after the surgery.
Both the rpFNA and the CNB procedures will be performed during your risk-reduction
mastectomy or partial mastectomy, under anesthesia, in addition to a blood draw, also
under anesthesia. Breast tissue will be sampled from the breast opposite to the cancer,
in patients referred for partial mastectomy or from the breast undergoing removal for
risk-reduction in the setting of a mastectomy.
Must be female, age 18 years or older
Eligible participants must have a planned bilateral or unilateral mastectomy for risk reduction or planned breast conservation surgery for unilateral breast malignancy (DCIS or invasive cancer)
Applicable Disease Sites
UW Hospital and Clinics