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Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin or Carboplatin and Etoposide
The purpose of this study is to compare the effects, good and/or bad, of two
different ways to give radiation therapy. One of the ways is experimental, while
one of them is standard. The experimental way of giving the radiation therapy is
once a day with a high dose of radiation for 7 weeks. The standard way of giving
the radiation therapy is to give it twice a day for 3 weeks. Everyone will get the
chemotherapy with cisplatin or carboplatin and etoposide, which has been
established through clinical trials to be standard drugs (chemotherapy) for your
type of cancer. The exact doses of the chemotherapy have not been completely
standardized and you will be receiving a commonly used dosing schedule. It is
not known what the added side effects are using this dose of chemotherapy with
either of the radiotherapy regimens.
You will be "randomized" into one of the study groups described below.
Randomization means that you are put into a group by chance. A computer
program will place you in one of the study groups. Neither you nor your doctor
can choose the group you will be in. You will have an equal chance of being
placed in either group. Those in Group 1 will receive the standard or usual dose of radiation therapy which is radiation therapy twice a day for 5 days each week, for about 3 weeks, along with chemotherapy. Those in Group 2 will receive a higher than standard dose of radiation therapy once a day for 5 days each week for about 7 weeks along with chemotherapy. Click here for more info
Proven diagnosis of small cell lung cancer, limited stage.
Patients must have measurable disease.
No prior radiation or chemotherapy. (Exceptions apply for patients that have enrolled in trial CALGB 30610).
Patients with complete surgical resection of disease are not eligible.
Applicable Disease Sites
Cytotoxic Chemotherapy; Other; Radiotherapy
carboplatin; cbdca (carboplatin); cis-diamminedichloroplatinum (cisplatin); cisplatin; etoposide; paraplatin (carboplatin); platinol (cisplatin); platinum (cisplatin); vepesid (etoposide); vp-16 (etoposide)
Aspirus UW Cancer Center (formerly Riverview Hospital); Johnson Creek, UW Cancer Center; UW Hospital and Clinics; UWCCC 1 South Park