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American Family Children's Hospital

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Protocol No. NRGGI004

Principal Investigator Mulkerin, Daniel

Phase III

Age Group Adult

Scope National

Sponsor Type National

Title Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or Without Atezolizumab or Atezolizumab

Applicable Disease Sites Colon and Rectum

Drugs Involved 5-fu (5-fluorouracil); Atezolizumab; Avastin (bevacizumab); Eloxatin (oxaliplatin); Eloxatina (oxaliplatin); L-OHP (oxaliplatin); MPDL3280A (Atezolizumab); SR 96669 (oxaliplatin); bevacizumab; leucovorin; leukovorin (leucovorin); lv (leucovorin); oxaliplatin; rhu Mab VEGF (bevacizumab); wellcovorin (leucovorin)

Status Open (affiliates only)

Participating Institutions Aspirus UW Cancer Center (formerly Riverview Hospital); Aspirus Wausau Hospital, Aspirus Regional Cancer Center; Langlade Memorial Hospital, Aspirus Regional Cancer Ctr; Mercy Health Systems, Janesville