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Phase II Study of Bendamustine and Rituximab Induction Chemoimmunotherapy Followed by Maintenance Rituximab + Lenalidomide in Previously Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
The purpose of this research is to evaluate a new combination of drugs for the treatment of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) using the drugs bendamustine (an intravenous chemotherapy drug), rituximab (an intravenous medication called a monoclonal antibody), and lenalidomide (an oral medication).
While bendamustine and rituximab are FDA approved for your type of cancer, lenalidomide is not FDA approved for your type of cancer, and is considered experimental. Linalidomide is a drug that alters the body's immune system (i.e., the part of your body that protects you from infection) and it may also interfere with the development of tiny blood vessels that help support tumor growth. This drug is considered experimental for treatment of your type of disease.
During the first 6 months of the study, you will be receiving bendamustine and rituximab treatment. After that, you will be receiving the lenalidomide capsule daily for 24 months, and receive treatments with rituximab every other month for 24 months. Click here for more info
- Histologically confirmed CLL/SL
- No prior cytotoxic chemotherapy for their disease; prior therapy with single-agent
rituximab is permitted
- Able to take aspirin (81 or 325 mg) daily as prophylactic anticoagulation
- Concurrent use of other anti-cancer agents or treatments is not allowed
- Not eligible if positive for HIV or infectious hepatitis (type B or C)
- Not eligible if positive for chronic hepatitis B or hepatitis C infection
Applicable Disease Sites
Cytotoxic Chemotherapy; Immunotherapy; Other
CC-5013 (Lenalidomide); Lenalidomide; Revlimid (Lenalidomide); SDX-105 (bendamustine); Treanda (bendamustine); bendamustine; chimeric anti-CD20 monoclonal antibody (rituximab); idec-c2B8 (rituximab); rituxan (rituximab); rituximab
UW Hospital and Clinics; UWCCC 1 South Park