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Protocol No. BMTCTN1704

Principal Investigator Juckett, Mark

Phase N/A

Age Group Adult

Scope National

Sponsor Type Externally Peer-Reviewed

Title Composite Health Assessment Risk Model for Older Adults: Applying Pre-transplant Comorbidity, Geriatric Assessment, and Biomarkers to Predict Non-Relapse Mortality after Allogeneic Transplant (CHARM)

Objective The goal of this study is to learn how to predict health after transplant, based on test results before transplant. The results may help doctors see if there is a way to tell which patients will have better health after transplant. This study does not include any experimental procedures

Treatment Subjects may receive any conditioning regimen, any stem cell source (e.g., bone marrow, peripheral blood stem cells, cord blood cells or a combination thereof), any allogeneic donor HLA-match (e.g., matched related, matched unrelated donor, mismatched donors, haploidentical donors) and any disease status. GVHD prophylaxis and supportive care will follow institutional standards. Maintenance therapy to prevent relapse is acceptable. Hematologic malignancy must be the primary indication for allogeneic HCT

Description Composite Health Assessment Model for Older Adults: Applying Pre-transplant Comorbidity, Geriatric Assessment and Biomarkers to Predict Non-Relapse Mortality After Allogeneic Transplantation for Older Adults (CHARM)

Key Eligibility
  • Subject is >great than 60 years old at time of enrollment.
  • Hematological malignancy as an indication for allogeneic transplantation
  • Eligible for allogeneic transplantation based on institutional standards
  • First allogeneic transplant planned. Any conditioning regimen and allogeneic donor is acceptable
  • Able to speak and read English. Spanish, and Mandarin will be acceptable when sites have ability to perform healthcare provider tests in those languages
    Exclusion Criteria
  • Prior allogeneic HCT

  • Applicable Disease Sites Hematologic cancers, other; Leukemia; Lymphoma; Multiple Myeloma

    Status Open

    Participating Institutions UW Hospital and Clinics