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American Family Children's Hospital
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Preimplantation Genetic Diagnosis (PGD)

Contact Information
 
For Appointments
(608) 824-6160
(888) 474-3933
Generations Fertility Care offers Preimplantation Genetic Diagnosis (PGD), a procedure that screens embryos for genetic defects prior to transferring them to the uterus. 

Candidates for Preimplantation Genetic Diagnosis (PGD)

The following groups are the most likely candidates for PGD:
  • Couples with a history of an inheritable genetic disease 
  • Parent(s) concerned with embryos carrying a single-cell defect that could lead to diseases such as cystic fibrosis, Tay-Sachs disease, sickle cell anemia, and Huntington disease

The Preimplantation Genetic Diagnosis (PGD) Procedure

 

PGD is a step within the In Vitro Fertilization (IVF) process during which the eggs are removed from the woman and fertilized within the clinic laboratory.

For patients who request PGD, the embryos are tested for any of a number of defects before being returned to the uterus. To do so, embryologists:

  • Take a biopsy - the removal of one cell for examination - of the three-day old embryo (which consists of approximately eight cells) 
  • The biopsied cell is sent to an external laboratory for the requested analysis, with results returned within 24-48 hours 
  • Embryos that pass the genetic screening are transferred into the uterus on the fifth or sixth day of culture
The Accuracy of Preimplantation Genetic Diagnosis (PGD)

No procedure is 100 percent accurate, including PGD. Potential drawbacks with the PGD procedure include:
  • Errors in the embryo analysis process, which are very rare but do occur 
  • Damage to the embryo during the biopsy