Movement problems (motor fluctuations) are the most common complication of long-term levodopa use. The majority of people who take levodopa develop these problems within 5 to 10 years. The main types of levodopa-related motor fluctuations include:
Motor fluctuations sometimes can be reduced or delayed by changing the schedule and amount of levodopa. Other medicines may be added to levodopa to help with motor fluctuations, such as dopamine agonists, COMT inhibitors, or MAO-B inhibitors. Increasingly, doctors are using dopamine agonists for initial treatment ofParkinson's disease, especially in younger people, to delay the development of motor fluctuations that eventually occur with long-term levodopa therapy.
Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
Adam Husney, MD - Family Medicine
Martin J. Gabica, MD - Family Medicine
Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer G. Frederick Wooten Jr., MD - Neurology
Current as ofOctober 9, 2017
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