Dense Deposit Disease
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Dense Deposit Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- membranoproliferative glomerulonephritis type II
- mesangial capillary glomerulonephritis
- mesangial proliferative glomerulonephritis
- MPGN type II
Dense deposit disease (DDD) is a rare kidney disease that stops the kidneys from correctly filtering waste from the blood. The name is descriptive of the electron-dense changes that transform the middle layer (lamina densa) of the glomerular basement membrane (GBM) in a segmental, discontinuous or diffuse pattern. The glomeruli are the filtering units of the kidney. Blood flows through very small capillaries in each glomerulus where it is filtered through the GBM to form urine. When DDD is present, deposits in the GBM lead to disruption of kidney function. Because damage to glomeruli is progressive, about half of all persons with DDD experience kidney failure after living with their disease for 10 years. The development of kidney failure means that dialysis or transplantation must be started.
In addition to dense deposits in the GBM, persons with DDD can develop deposits in their eyes along an interface called the choriocapillaris-Bruch's membrane-retinal pigment epithelium. This region is very similar to the capillary-GBM interface in the kidney. The eye deposits are called drusen.
Genetic and Rare Diseases (GARD) Information Center
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- The Greater Cedar Rapids Community Foundation
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- Email: kidneedsMPGN@yahoo.com
- Website: http://www.healthcare.uiowa.edu/kidneeds/index.htm
National Kidney Foundation
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
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Last Updated: 12/7/1969
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