didanosine

Pronunciation: dye DAN oh seen

Brand: Videx, Videx EC

Didanosine 200 mg-BAR

slide 1 of 4, Didanosine 200 mg-BAR,

capsule, green/white, imprinted with barr 200mg, 588

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Didanosine 250 mg-BAR

slide 2 of 4, Didanosine 250 mg-BAR,

capsule, blue/white, imprinted with barr 250mg, 589

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Didanosine 400 mg-BAR

slide 3 of 4, Didanosine 400 mg-BAR,

capsule, red/white, imprinted with barr 400mg, 590

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Videx EC 250 mg

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capsule, white, imprinted with BMS 250MG, 6673

Image of Videx EC 250 mg
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What is the most important information I should know about didanosine?

Do not take didanosine together with allopurinol, ribavirin, or stavudine.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

This medicine can also cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have: severe pain in your upper stomach (may spread to your back), nausea and vomiting, fast heart rate, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What is didanosine?

Didanosine is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Didanosine is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Didanosine is not a cure for HIV or AIDS.

Didanosine is for use in adults and children who are at least 2 weeks old.

Didanosine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking didanosine?

You should not use didanosine if you are allergic to it. Do not take didanosine together with allopurinol, ribavirin, or stavudine.

Tell your doctor if you have ever had:

  • liver disease or pancreatitis (didanosine can cause severe or life-threatening effects on your liver or pancreas);
  • kidney disease (or if you are on dialysis);
  • numbness or tingling in your hands or feet, including Raynaud's syndrome; or
  • if you drink large amounts of alcohol.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

If you are pregnant, do not take didanosine together with stavudine. This combination can be very dangerous during pregnancy.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take didanosine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take didanosine on an empty stomach, at least 30 minutes before or 2 hours after a meal. Do not take with food.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Swallow the capsule whole and do not crush, chew, break, or open it.

HIV/AIDS is usually treated with a combination of drugs, but certain HIV medications or antibiotics should not be taken at the same time as didanosine. These other medicines can affect the levels of didanosine in your blood stream:

  • Ciprofloxacin should be taken at least 2 hours before or 6 hours after you take didanosine.
  • Delavirdine or indinavir should be taken at least 1 hour before you take didanosine.
  • Nelfinavir should be taken at least 1 hour after you take didanosine.
  • Itraconazole or ketoconazole should be taken at least 2 hours before you take didanosine.

Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

You will need frequent medical tests. Your vision may also need to be checked.

Store the tablets or capsules at room temperature in a tightly closed container, away from moisture and heat.

Store the liquid in the refrigerator. Throw away any leftover didanosine liquid that is more than 30 days old.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking didanosine?

Do not drink alcohol. It may increase your risk of liver damage or pancreatitis.

Avoid using antacids without your doctor's advice while taking didanosine. Use only the specific type of antacid your doctor recommends.

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of didanosine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have:

  • numbness, tingling, or pain in your hands or feet;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • vision changes; or
  • signs of liver or pancreas problems --loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Didanosine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

  • signs of a new infection --fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects may include:

  • nausea, vomiting, diarrhea, stomach pain;
  • rash;
  • headache; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect didanosine?

Many drugs can affect didanosine, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about didanosine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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