Pronunciation: oh MEP ra zol

Brand: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, PriLOSEC, PriLOSEC OTC

Omeprazole 10 mg-TEV

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brown/lavender, imprinted with 081, IMPAX10

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Omeprazole 20 mg-APO

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capsule, brown/pink, imprinted with APO, 020

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Omeprazole 20 mg-KU

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capsule, white/yellow, imprinted with KU, 118

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Omeprazole 20 mg-MYL

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capsule, green, imprinted with MYLAN 6150

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Omeprazole 20 mg-TEV

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purple, imprinted with 082, IMPAX 20

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Prilosec 10 mg

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capsule, purple, imprinted with 606, PRILOSEC 10

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Prilosec 20 mg

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capsule, purple, imprinted with 607, PRILOSEC 20

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Prilosec 40 mg

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capsule, purple, imprinted with 743, PRILOSEC 40

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What is the most important information I should know about omeprazole?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is omeprazole?

Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Omeprazole may also be given together with antibiotics to treat gastric ulcer caused by infection with helicobacter pylori (H. pylori).

Over-the-counter (OTC) omeprazole is used to help control heartburn that occurs 2 or more days per week. This medicine not for immediate relief of heartburn symptoms. OTC omeprazole must be taken on a regular basis for 14 days in a row.

Omeprazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking omeprazole?

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.

You should not use omeprazole if you are allergic to it, or if:

  • you are allergic to other proton pump inhibitors (esomeprazole, lansoprazole, pantoprazole, rabeprazole, Dexilant, Nexium, Prevacid, Protonix, AcipHex, and others); or
  • you also take HIV medication that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca).

Ask a doctor or pharmacist if it is safe for you to use omeprazole if you have other medical conditions, especially:

  • trouble or pain with swallowing;
  • bloody or black stools, vomit that looks like blood or coffee grounds;
  • heartburn that has lasted for over 3 months;
  • frequent chest pain, heartburn with wheezing;
  • unexplained weight loss;
  • nausea or vomiting, stomach pain;
  • liver disease;
  • low levels of magnesium in your blood; or
  • osteoporosis or low bone mineral density (osteopenia).

You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor. Talk with your doctor about ways to keep your bones healthy.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not use this medicine without a doctor's advice if you are breast-feeding.

Do not give this medicine to a child without medical advice.

How should I take omeprazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Use Prilosec OTC (over-the-counter) exactly as directed on the label, or as prescribed by your doctor.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

You must dissolve omeprazole powder in a small amount of water. This mixture can either be swallowed or given through a nasogastric (NG) feeding tube using a catheter-tipped syringe.

OTC omeprazole should be taken for only 14 days in a row. Allow at least 4 months to pass before you start a new 14-day course of treatment.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

Taking omeprazole long-term could cause you to develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition.

Call your doctor if your symptoms do not improve, or if they get worse.

Some conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using omeprazole.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking omeprazole?

Diarrhea may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

What are the possible side effects of omeprazole?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using omeprazole and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • a rash or joint pain;
  • new or unusual pain in your wrist, thigh, hip, or back;
  • seizure (convulsions);
  • kidney problems --urinating more or less than usual, blood in your urine, swelling, rapid weight gain; or
  • symptoms of low magnesium --drowsiness, confusion, feeling irritable, fast heartbeats, tremors, twitching, muscle cramps, numbness, tingling, or seizure.

Common side effects may include:

  • stomach pain, gas;
  • nausea, vomiting, diarrhea; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect omeprazole?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Ask a doctor or pharmacist before using omeprazole with any other medications, especially:

  • diazepam (Valium);
  • digoxin;
  • methotrexate;
  • mycophenolate mofetil;
  • tacrolimus;
  • an antibiotic --ampicillin, amoxicillin, clarithromycin, rifampin;
  • antifungal medicine --ketoconazole, voriconazole;
  • HIV medication --atazanavir, nelfinavir, saquinavir;
  • iron-containing medicines --ferrous fumarate, ferrous gluconate, ferrous sulfate, and others; or
  • medicine to prevent blood clots --cilostazol, clopidogrel, warfarin (Coumadin, Jantoven).

This list is not complete and many other drugs may affect omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about omeprazole.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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