pertuzumab

Pronunciation: per TOO zoo mab

Brand: Perjeta

What is the most important information I should know about pertuzumab?

Pertuzumab can cause birth defects or death to the unborn baby. Do not use if you are pregnant. Avoid getting pregnant while using this medicine and for at least 7 months after your last dose.

Pertuzumab can cause life-threatening heart problems. Call your doctor at once if you have new or worsening cough, shortness of breath, or swelling in your lower legs.

What is pertuzumab?

Pertuzumab is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Pertuzumab is used together with other cancer medicines (trastuzumab and docetaxel) to treat HER2-positive breast cancer.

Pertuzumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving pertuzumab?

You should not use pertuzumab if you are allergic to it, or if you are pregnant or breast-feeding.

Tell your doctor if you have ever had:

  • heart disease, congestive heart failure, heart rhythm disorder;
  • untreated or uncontrolled high blood pressure (hypertension);
  • a heart attack; or
  • radiation treatment in your chest area.

Do not use pertuzumab if you are pregnant. It can cause birth defects or death to the unborn baby. Use effective birth control to prevent pregnancy while you are using pertuzumab with trastuzumab, and for at least 7 months after your treatment ends. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of pertuzumab on the baby.

You should not breast-feed while you are using pertuzumab.

How is pertuzumab given?

Pertuzumab is given as an infusion into a vein. A healthcare provider will give you this injection.

Pertuzumab is usually given once every 3 weeks. Follow your doctor's instructions.

Pertuzumab can cause life-threatening heart problems. Your heart function may need to be checked before you start using pertuzumab and during your treatment.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your pertuzumab injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving pertuzumab?

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

What are the possible side effects of pertuzumab?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your caregiver right away if you feel weak, tired, or nauseated, or if you have a fast heartbeat, headache, fever, chills, muscle pain, or an unusual taste in your mouth.

Call your doctor at once if you have:

  • dizziness, pounding heartbeats or fluttering in your chest;
  • new or worsening cough or shortness of breath;
  • swelling in your lower legs; or
  • low blood cell counts --fever, chills, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects are more likely to occur, such as:

  • nausea, diarrhea;
  • temporary hair loss;
  • fever, low blood cell counts;
  • tiredness;
  • rash; or
  • numbness, tingling, or burning pain in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect pertuzumab?

Other drugs may affect pertuzumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about pertuzumab.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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