Vincent L. Cryns, MD close
Vincent L. Cryns, MD

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Vincent L. Cryns, MD Print Friendly Page

Dr. Cryns is Chief of the Division of Endocrinology, Diabetes and Metabolism. His major clinical interests are osteoporosis, general endocrinology and metabolic disorders.



West Clinic
(608) 263-5010 | (800) 323-8942 | Map
West Clinic
(608) 263-5010 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Endocrinology, Diabetes & Metabolism
Fellowship Massachusetts General Hospital, Boston, MA
Residency Dartmouth Hitchcock Medical Center, Lebanon, NH
Internship Massachusetts General Hospital, Boston, MA
Medical School Harvard Medical School, Boston, MA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Cryns' research focuses on understanding how cells die. He leads a team of scientists who are interested in understanding how abnormalities in cell death contribute to cancer and obesity and in translating these insights into improved therapies. Dr. Cryns' research is funded by the NIH, the Breast Cancer Research Foundation, and other agencies. His work has been featured on National Public Radio's "All Things Considered" and highlighted in Nature and Nature Reviews Cancer. Dr. Cryns has been the recipient of several awards, including an Outstanding Junior Faculty Award from the Avon Foundation, and he is an elected member of the American Society for Clinical Investigation.

PubMed Articles
Richards KA Liou JI Cryns VL Downs TM Abel EJ Jarrard DF Metformin Use is Associated with Improved Survival for Patients with Advanced Prostate Cancer on Androgen Deprivation Therapy. J Urol . 2018 Dec;200(6):1256-1263
[PubMed ID: 29940252]
Ugolkov AV Matsangou M Taxter TJ O'Halloran TV Cryns VL Giles FJ Mazar AP Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer. Oncol Lett . 2018 Nov;16(5):6437-6444
[PubMed ID: 30405781]
Yu D Yang SE Miller BR Wisinski JA Sherman DS Brinkman JA Tomasiewicz JL Cummings NE Kimple ME Cryns VL Lamming DW Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. FASEB J . 2018 Jun;32(6):3471-3482
[PubMed ID: 29401631]
Hanseree P Staples AC Cryns VL Hansen KE Hypocalciuria as a Predictor of Reduced Intestinal Calcium Absorption. J Endocr Soc . 2017 Sep 1;1(9):1179-1187
[PubMed ID: 29264573]
Strekalova E Malin D Rajanala H Cryns VL Metformin sensitizes triple-negative breast cancer to proapoptotic TRAIL receptor agonists by suppressing XIAP expression. Breast Cancer Res Treat . 2017 Jun;163(3):435-447
[PubMed ID: 28324269]
Ugolkov A Gaisina I Zhang JS Billadeau DD White K Kozikowski A Jain S Cristofanilli M Giles F O'Halloran T Cryns VL Mazar AP GSK-3 inhibition overcomes chemoresistance in human breast cancer. Cancer Lett . 2016 Oct 1;380(2):384-92
[PubMed ID: 27424289]
Toft DJ Fuller M Schipma M Chen F Cryns VL Layden BT αB-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance. Genom Data . 2016 Sep;9:10-7
[PubMed ID: 27330996]
Malin D Petrovic V Strekalova E Sharma B Cryns VL αB-crystallin: Portrait of a malignant chaperone as a cancer therapeutic target. Pharmacol Ther . 2016 Apr;160:1-10
[PubMed ID: 26820756]
Malin D Strekalova E Petrovic V Rajanala H Sharma B Ugolkov A Gradishar WJ Cryns VL ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo. Oncogene . 2015 Nov 5;34(45):5626-34
[PubMed ID: 25684139]
Voduc KD Nielsen TO Perou CM Harrell JC Fan C Kennecke H Minn AJ Cryns VL Cheang MCU αB-crystallin Expression in Breast Cancer is Associated with Brain Metastasis. NPJ Breast Cancer . 2015 Oct 21;1
[PubMed ID: 27656679]
Strekalova E Malin D Good DM Cryns VL Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression. Clin Cancer Res . 2015 Jun 15;21(12):2780-91
[PubMed ID: 25724522]
Fernando IR Ferris DP Frasconi M Malin D Strekalova E Yilmaz MD Ambrogio MW Algaradah MM Hong MP Chen X Nassar MS Botros YY Cryns VL Stoddart JF Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery. Nanoscale . 2015 Apr 28;7(16):7178-83
[PubMed ID: 25820516]
Halo TL McMahon KM Angeloni NL Xu Y Wang W Chinen AB Malin D Strekalova E Cryns VL Cheng C Mirkin CA Thaxton CS NanoFlares for the detection, isolation, and culture of live tumor cells from human blood. Proc Natl Acad Sci U S A . 2014 Dec 2;111(48):17104-9
[PubMed ID: 25404304]
Moyer TJ Finbloom JA Chen F Toft DJ Cryns VL Stupp SI pH and amphiphilic structure direct supramolecular behavior in biofunctional assemblies. J Am Chem Soc . 2014 Oct 22;136(42):14746-52
[PubMed ID: 25310840]
Malin D Strekalova E Petrovic V Deal AM Al Ahmad A Adamo B Miller CR Ugolkov A Livasy C Fritchie K Hamilton E Blackwell K Geradts J Ewend M Carey L Shusta EV Anders CK Cryns VL αB-crystallin: a novel regulator of breast cancer metastasis to the brain. Clin Cancer Res . 2014 Jan 1;20(1):56-67
[PubMed ID: 24132917]
Frasconi M Liu Z Lei J Wu Y Strekalova E Malin D Ambrogio MW Chen X Botros YY Cryns VL Sauvage JP Stoddart JF Photoexpulsion of surface-grafted ruthenium complexes and subsequent release of cytotoxic cargos to cancer cells from mesoporous silica nanoparticles. J Am Chem Soc . 2013 Aug 7;135(31):11603-13
[PubMed ID: 23815127]
Petrovic V Malin D Cryns VL αB-crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation. Breast Cancer Res Treat . 2013 Apr;138(2):415-25
[PubMed ID: 23471649]
Goldberg MS Hook SS Wang AZ Bulte JW Patri AK Uckun FM Cryns VL Hanes J Akin D Hall JB Gharkholo N Mumper RJ Biotargeted nanomedicines for cancer: six tenets before you begin. Nanomedicine (Lond) . 2013 Feb;8(2):299-308
[PubMed ID: 23394158]
Toft DJ Moyer TJ Standley SM Ruff Y Ugolkov A Stupp SI Cryns VL Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer. ACS Nano . 2012 Sep 25;6(9):7956-65
[PubMed ID: 22928955]
Soukasene S Toft DJ Moyer TJ Lu H Lee HK Standley SM Cryns VL Stupp SI Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin. ACS Nano . 2011 Nov 22;5(11):9113-21
[PubMed ID: 22044255]