Vincent L. Cryns, MD close
Vincent L. Cryns, MD

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Vincent L. Cryns, MD Print Friendly Page

Dr. Cryns is Chief of the Division of Endocrinology, Diabetes and Metabolism. His major clinical interests are osteoporosis, general endocrinology and metabolic disorders.


Endocrinology, Diabetes and Metabolism




West Clinic
(608) 263-5010 | (800) 323-8942 | Map
West Clinic
(608) 263-5010 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Endocrinology, Diabetes & Metabolism
Fellowship Massachusetts General Hospital, Boston, MA
Residency Dartmouth Hitchcock Medical Center, Lebanon, NH
Internship Massachusetts General Hospital, Boston, MA
Medical School Harvard Medical School, Boston, MA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Cryns' research focuses on understanding how cells die. He leads a team of scientists who are interested in understanding how abnormalities in cell death contribute to cancer and obesity and in translating these insights into improved therapies. Dr. Cryns' research is funded by the NIH, the Breast Cancer Research Foundation, and other agencies. His work has been featured on National Public Radio's "All Things Considered" and highlighted in Nature and Nature Reviews Cancer. Dr. Cryns has been the recipient of several awards, including an Outstanding Junior Faculty Award from the Avon Foundation, and he is an elected member of the American Society for Clinical Investigation.

PubMed Articles
Bruckbauer ST Minkoff BB Yu D Cryns VL Cox MM Sussman MR Ionizing radiation-induced proteomic oxidation in <i>Escherichia coli</i>. Mol Cell Proteomics . 2020 Jun 14;
[PubMed ID: 32536603]
Haws SA Yu D Ye C Wille CK Nguyen LC Krautkramer KA Tomasiewicz JL Yang SE Miller BR Liu WH Igarashi K Sridharan R Tu BP Cryns VL Lamming DW Denu JM Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Mol Cell . 2020 Apr 16;78(2):210-223.e8
[PubMed ID: 32208170]
Chen M Wen T Horn HT Chandrahas VK Thapa N Choi S Cryns VL Anderson RA The nuclear phosphoinositide response to stress. Cell Cycle . 2020 Feb;19(3):268-289
[PubMed ID: 31902273]
Rajanala SH Ringquist R Cryns VL Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism. Am J Cancer Res . 2019;9(8):1766-1775
[PubMed ID: 31497357]
Strekalova E Malin D Weisenhorn EMM Russell JD Hoelper D Jain A Coon JJ Lewis PW Cryns VL S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells. Breast Cancer Res Treat . 2019 May;175(1):39-50
[PubMed ID: 30712196]
Choi S Chen M Cryns VL Anderson RA A nuclear phosphoinositide kinase complex regulates p53. Nat Cell Biol . 2019 Apr;21(4):462-475
[PubMed ID: 30886346]
Etheridge T Damodaran S Schultz A Richards KA Gawdzik J Yang B Cryns V Jarrard DF Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier. Asian J Urol . 2019 Jan;6(1):57-64
[PubMed ID: 30775249]
Strekalova E Malin D Rajanala H Cryns VL Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction. Methods Mol Biol . 2019;1866:61-73
[PubMed ID: 30725408]
Richards KA Liou JI Cryns VL Downs TM Abel EJ Jarrard DF Metformin Use is Associated with Improved Survival for Patients with Advanced Prostate Cancer on Androgen Deprivation Therapy. J Urol . 2018 Dec;200(6):1256-1263
[PubMed ID: 29940252]
Ugolkov AV Matsangou M Taxter TJ O'Halloran TV Cryns VL Giles FJ Mazar AP Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer. Oncol Lett . 2018 Nov;16(5):6437-6444
[PubMed ID: 30405781]
Yu D Yang SE Miller BR Wisinski JA Sherman DS Brinkman JA Tomasiewicz JL Cummings NE Kimple ME Cryns VL Lamming DW Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. FASEB J . 2018 Jun;32(6):3471-3482
[PubMed ID: 29401631]
Hanseree P Staples AC Cryns VL Hansen KE Hypocalciuria as a Predictor of Reduced Intestinal Calcium Absorption. J Endocr Soc . 2017 Sep 1;1(9):1179-1187
[PubMed ID: 29264573]
Strekalova E Malin D Rajanala H Cryns VL Metformin sensitizes triple-negative breast cancer to proapoptotic TRAIL receptor agonists by suppressing XIAP expression. Breast Cancer Res Treat . 2017 Jun;163(3):435-447
[PubMed ID: 28324269]
Ugolkov A Gaisina I Zhang JS Billadeau DD White K Kozikowski A Jain S Cristofanilli M Giles F O'Halloran T Cryns VL Mazar AP GSK-3 inhibition overcomes chemoresistance in human breast cancer. Cancer Lett . 2016 Oct 1;380(2):384-92
[PubMed ID: 27424289]
Toft DJ Fuller M Schipma M Chen F Cryns VL Layden BT αB-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance. Genom Data . 2016 Sep;9:10-7
[PubMed ID: 27330996]
Malin D Petrovic V Strekalova E Sharma B Cryns VL αB-crystallin: Portrait of a malignant chaperone as a cancer therapeutic target. Pharmacol Ther . 2016 Apr;160:1-10
[PubMed ID: 26820756]
Malin D Strekalova E Petrovic V Rajanala H Sharma B Ugolkov A Gradishar WJ Cryns VL ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo. Oncogene . 2015 Nov 5;34(45):5626-34
[PubMed ID: 25684139]
Voduc KD Nielsen TO Perou CM Harrell JC Fan C Kennecke H Minn AJ Cryns VL Cheang MCU αB-crystallin Expression in Breast Cancer is Associated with Brain Metastasis. NPJ Breast Cancer . 2015 Oct 21;1
[PubMed ID: 27656679]
Strekalova E Malin D Good DM Cryns VL Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression. Clin Cancer Res . 2015 Jun 15;21(12):2780-91
[PubMed ID: 25724522]
Fernando IR Ferris DP Frasconi M Malin D Strekalova E Yilmaz MD Ambrogio MW Algaradah MM Hong MP Chen X Nassar MS Botros YY Cryns VL Stoddart JF Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery. Nanoscale . 2015 Apr 28;7(16):7178-83
[PubMed ID: 25820516]