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Paul M. Sondel, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Paul Sondel, M.D., Ph.D. is the Reed and Carolee Walker Professor in Pediatric Oncology at the University of Wisconsin – Madison. 
 
Dr. Sondel, a Milwaukee native, completed undergraduate and graduate education at UW-Madison leading to a Ph.D. in Genetics (1975), with guidance from Bone Marrow Transplant pioneer, Fritz Bach, M.D. He received his M.D. magna cum laude in 1977 from Harvard Medical School, while beginning his research in tumor immunology. Following pediatric residency training at the Universities of Minnesota and Wisconsin, he joined the faculty of UW-Madison in 1980 in the Departments of Pediatrics, Human Oncology and Genetics. He was promoted to professor in 1987, and became leader of the UW Carbone Cancer Center's Program in Immunology and Immunotherapy in 1990, when he also became Head of the Division of Pediatric Oncology.
 
Dr. Sondel has been a leader in scientific policy through multiple national committee roles, including The National Institutes of Health, The American Cancer Society, The Children's Oncology Group (COG), The National Cancer Institute, where he was a member of the Board of Scientific Counselors, and St. Jude's Children’s Research Hospital, where he was the Chair of their Scientific Advisory Committee and is now chair of their cancer center's external advisory board.
 
Clinically, he has worked with COG in contributing to the progress of the past 30 years in the development of curative treatments for childhood cancers. He is devoted to his own patients, and committed to leading a multidisciplinary team that is providing comprehensive and compassionate, state of the art treatment for all childhood cancer and hematology patients at the University of Wisconsin.

Specialties

Pediatric Hematology and Oncology

Acute Lymphoblastic Leukemia

Adrenocortical carcinoma

Aplastic Anemia

Astrocytoma

Ataxia-telengiectasia

Atypical Teratoid/Rhabdoid tumor

Bone Marrow Biopsy

Brain Stem Glioma

CAR T-cell Therapy (Pediatric)

Chemotherapy

Chronic Myeloid Leukemia

Congenital Hemolytic Anemias

Craniopharyngioma

Cyclic Neutropenia

Diamond-Blackfan Syndrome

Endocrine Tumors

Ependymoma

Ewing Sarcoma

Fanconi's Anemia

Germ Cell Tumors

Hemophagocytic Lymphohistiocytosis

Hemophilia A

Hemophilia B

Hepatoblastoma

Hereditary Spherocytosis

Hodgkin's Disease

I-131 MIBG (Metaiodobenzylguadine)

Immune Thrombocytopenc Purpura

Immunotherapy

Juvenile Myelomonocytic Leukemia

Kostmann Syndrome

Langerhans' Cell Histiocytosis

Lumbar Puncture

Medulloblastoma

Myelodysplastic Syndromes

Neuroblastoma

Neurocutaneous Syndrome

Neurofibromatosis

Non-Hodgkin Lymphomas

Optic Glioma

Osteosarcoma

Paroxysmal Nocturnal Hemoglobinuria

Pediatric Cancer

Pediatric Sickle Cell Disease

Rhabdomyosarcoma

Schwanomatosis

Shwachman-Diamond Syndrome

Sturge-Weber Syndrome

Thalassemia Syndromes

Thrombophilia

Thyroid Tumors

Tuberous Sclerosis

Vascular malformations

Von Willebrand Disease

VonHippel-Lindau Disease

Clinics

American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatrics
Fellowship

Pediatric Oncology, Midwest Children's Cancer Center at Children's Hospital of Wisconsin, Milwaukee, WI


Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship University of Minnesota Affiliated Hospitals, Minneapolis, MN
Medical School Harvard Medical School, Boston, MA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
Research
Dr. Sondel's research has emphasized the translation of laboratory innovations into clinical progress. His laboratory has pursued the biology of graft-versus-leukemia reactions, activation of anti-tumor immune destruction with Interleukin-2 and the use of tumor reactive monoclonal antibodies to facilitate tumor killing by lymphocytes. These studies have all moved into clinical testing led by Dr. Sondel at UW, and in national studies he has led through the Children’s Oncology Group (COG).

He has published more than 360 scientific articles and chapters, and his laboratory has provided training for 58 graduate students and post-doctoral fellows.

Learn more about Dr. Sondel's research: UW-Madison Department of Genetics | Sondel Laboratory


PubMed Articles
Baniel CC Sumiec EG Hank JA Bates AM Erbe AK Pieper AA Hoefges AG Patel RB Rakhmilevich AL Morris ZS Sondel PM Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model. J Immunother Cancer . 2020 Oct;8(2)
[PubMed ID: 33115944]
Damodharan SN Walker KL Forsberg MH McDowell KA Bouchlaka MN Drier DA Sondel PM DeSantes KB Capitini CM Analysis of ex vivo expanded and activated clinical-grade human NK cells after cryopreservation. Cytotherapy . 2020 Aug;22(8):450-457
[PubMed ID: 32536506]
Baniel CC Heinze CM Hoefges A Sumiec EG Hank JA Carlson PM Jin WJ Patel RB Sriramaneni RN Gillies SD Erbe AK Schwarz CN Pieper AA Rakhmilevich AL Sondel PM Morris ZS <i>In situ</i> Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response. Front Immunol . 2020;11:1610
[PubMed ID: 32849544]
Yang RK Kuznetsov IB Ranheim EA Wei JS Sindiri S Gryder BE Gangalapudi V Song YK Patel V Hank JA Zuleger C Erbe AK Morris ZS Quale R Kim K Albertini MR Khan J Sondel PM Outcome-Related Signatures Identified by Whole Transcriptome Sequencing of Resectable Stage III/IV Melanoma Evaluated after Starting Hu14.18-IL2. Clin Cancer Res . 2020 Jul 1;26(13):3296-3306
[PubMed ID: 32152202]
Mody R Yu AL Naranjo A Zhang FF London WB Shulkin BL Parisi MT Servaes SE Diccianni MB Hank JA Felder M Birstler J Sondel PM Asgharzadeh S Glade-Bender J Katzenstein H Maris JM Park JR Bagatell R Irinotecan, Temozolomide, and Dinutuximab With GM-CSF in Children With Refractory or Relapsed Neuroblastoma: A Report From the Children's Oncology Group. J Clin Oncol . 2020 Jul 1;38(19):2160-2169
[PubMed ID: 32343642]
Ascierto PA Fox BA Urba WJ Anderson AC Atkins MB Borden EC Brahmer JR Butterfield LH Cesano A Chen DC de Gruijl TD Dillman RO Drake CG Emens LA Gajewski TF Gulley JL Stephen Hodi FJ Hwu P Kaufman D Kaufman HL Lotze MT McNeel DG Margolin KM Marincola FM Mastrangelo MJ Maus MV Parkinson DR Romero PJ Sondel PM Spranger S Sznol M Weiner GJ Wigginton JM Weber JS Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19. J Immunother Cancer . 2020 Apr;8(1)
[PubMed ID: 32300051]
Pearson ADJ Rossig C Lesa G Diede SJ Weiner S Anderson J Gray J Geoerger B Minard-Colin V Marshall LV Smith M Sondel P Bajars M Baldazzi C Barry E Blackman S Blanc P Capdeville R Caron H Cole PD Jiménez JC Demolis P Donoghue M Elgadi M Gajewski T Galluzzo S Ilaria R Jr Jenkner A Karres D Kieran M Ligas F Lowy I Meyers M Oprea C Peddareddigari VGR Sterba J Stockman PK Suenaert P Tabori U van Tilburg C Yancey T Weigel B Norga K Reaman G Vassal G ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients. Eur J Cancer . 2020 Mar;127:52-66
[PubMed ID: 31986450]
Goldberg JL Navid F Hank JA Erbe AK Santana V Gan J de Bie F Javaid AM Hoefges A Merdler M Carmichael L Kim K Bishop MW Meager MM Gillies SD Pandey JP Sondel PM Pre-existing antitherapeutic antibodies against the Fc region of the hu14.18K322A mAb are associated with outcome in patients with relapsed neuroblastoma. J Immunother Cancer . 2020 Mar;8(1)
[PubMed ID: 32169872]
Bishop MW Hutson PR Hank JA Sondel PM Furman WL Meagher MM Navid F Santana VM A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors. MAbs . 2020 Jan-Dec;12(1):1773751
[PubMed ID: 32643524]
Voeller J Erbe AK Slowinski J Rasmussen K Carlson PM Hoefges A VandenHeuvel S Stuckwisch A Wang X Gillies SD Patel RB Farrel A Rokita JL Maris J Hank JA Morris ZS Rakhmilevich AL Sondel PM Combined innate and adaptive immunotherapy overcomes resistance of immunologically cold syngeneic murine neuroblastoma to checkpoint inhibition. J Immunother Cancer . 2019 Dec 6;7(1):344
[PubMed ID: 31810498]
Furman WL Federico SM McCarville MB Shulkin BL Davidoff AM Krasin MJ Sahr N Sykes A Wu J Brennan RC Bishop MW Helmig S Stewart E Navid F Triplett B Santana VM Bahrami A Anthony G Yu AL Hank J Gillies SD Sondel PM Leung WH Pappo AS A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma. Clin Cancer Res . 2019 Nov 1;25(21):6320-6328
[PubMed ID: 31601569]
Shusterman S Naranjo A Van Ryn C Hank JA Parisi MT Shulkin BL Servaes S London WB Shimada H Gan J Gillies SD Maris JM Park JR Sondel PM Antitumor Activity and Tolerability of hu14.18-IL2 with GMCSF and Isotretinoin in Recurrent or Refractory Neuroblastoma: A Children's Oncology Group Phase II Study. Clin Cancer Res . 2019 Oct 15;25(20):6044-6051
[PubMed ID: 31358541]
Voeller J Sondel PM Advances in Anti-GD2 Immunotherapy for Treatment of High-risk Neuroblastoma. J Pediatr Hematol Oncol . 2019 Apr;41(3):163-169
[PubMed ID: 30897608]
Erbe AK Wang W Carmichael L Hoefges A Grzywacz B Reville PK Ranheim EA Hank JA Kim K Seo S Mendonca EA Song Y Kenkre VP Hong F Gascoyne RD Paietta E Horning SJ Miller JS Kahl B Sondel PM Follicular lymphoma patients with KIR2DL2 and KIR3DL1 and their ligands (HLA-C1 and HLA-Bw4) show improved outcome when receiving rituximab. J Immunother Cancer . 2019 Mar 12;7(1):70
[PubMed ID: 30871628]
Felder M Kapur A Rakhmilevich AL Qu X Sondel PM Gillies SD Connor J Patankar MS MUC16 suppresses human and murine innate immune responses. Gynecol Oncol . 2019 Mar;152(3):618-628
[PubMed ID: 30626487]
Hernandez R Walker KL Grudzinski JJ Aluicio-Sarduy E Patel R Zahm CD Pinchuk AN Massey CF Bitton AN Brown RJ Sondel PM Morris ZS Engle JW Capitini CM Weichert JP <sup>90</sup>Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin's Lymphoma. Commun Biol . 2019;2:79
[PubMed ID: 30820474]
Ayuso JM Truttschel R Gong MM Humayun M Virumbrales-Munoz M Vitek R Felder M Gillies SD Sondel P Wisinski KB Patankar M Beebe DJ Skala MC Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model. Oncoimmunology . 2019;8(3):1553477
[PubMed ID: 30723584]
Graul-Conroy A Hoover-Regan M DeSantes KB Sondel PM Callander NS Longo WL Fahl WE Reduction in oral mucositis severity using a topical vasoconstrictor: A case report of three bone marrow transplant patients. Integr Cancer Sci Ther . 2018 Dec;5(6)
[PubMed ID: 31832233]
Wei JS Kuznetsov IB Zhang S Song YK Asgharzadeh S Sindiri S Wen X Patidar R Najaraj S Walton A Auvil JMG Gerhard DS Yuksel A Catchpoole D Hewitt SM Sondel PM Seeger R Maris JM Khan J Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk <i>MYCN</i>-Not-Amplified Human Neuroblastoma. Clin Cancer Res . 2018 Nov 15;24(22):5673-5684
[PubMed ID: 29784674]
Albertini MR Yang RK Ranheim EA Hank JA Zuleger CL Weber S Neuman H Hartig G Weigel T Mahvi D Henry MB Quale R McFarland T Gan J Carmichael L Kim K Loibner H Gillies SD Sondel PM Pilot trial of the hu14.18-IL2 immunocytokine in patients with completely resectable recurrent stage III or stage IV melanoma. Cancer Immunol Immunother . 2018 Oct;67(10):1647-1658
[PubMed ID: 30073390]