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Miriam A. Shelef, MD, PhD

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Miriam A. Shelef, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health


Rheumatology and Arthritis

Auto Immune Disorders

Rheumatoid Arthritis


West Clinic
(608) 263-7577 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Medical School Columbia University College of Physicians and Surgeons, New York, NY

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
PubMed Articles
Edwards NJ Hwang C Marini S Pagani CA Spreadborough PJ Rowe CJ Yu P Mei A Visser N Li S Hespe GE Huber AK Strong AL Shelef MA Knight JS Davis TA Levi B The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury. FASEB J . 2020 Oct 22;
[PubMed ID: 33089917]
Heffron AS McIlwain SJ Baker DA Amjadi MF Khullar S Sethi AK Shelef MA O'Connor DH Ong IM The landscape of antibody binding to SARS-CoV-2. bioRxiv . 2020 Oct 11;
[PubMed ID: 33052349]
Golenberg N Squirrell JM Bennin DA Rindy J Pistono PE Eliceiri KW Shelef MA Kang J Huttenlocher A Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol . 2020 Apr 6;219(4)
[PubMed ID: 32328635]
Zheng Z Mergaert AM Fahmy LM Bawadekar M Holmes CL Ong IM Bridges AJ Newton MA Shelef MA Disordered Antigens and Epitope Overlap Between Anti-Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis. Arthritis Rheumatol . 2020 Feb;72(2):262-272
[PubMed ID: 31397047]
Sun B Chang HH Salinger A Tomita B Bawadekar M Holmes CL Shelef MA Weerapana E Thompson PR Ho IC Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight . 2019 Nov 14;4(22)
[PubMed ID: 31723060]
Shelef MA New Relationships for Old Autoantibodies in Rheumatoid Arthritis. Arthritis Rheumatol . 2019 Sep;71(9):1396-1399
[PubMed ID: 30861623]
Mergaert AM Bawadekar M Nguyen TQ Massarenti L Holmes CL Rebernick R Schrodi SJ Shelef MA Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans. Int J Mol Sci . 2019 Jun 25;20(12)
[PubMed ID: 31242568]
Holmes CL Peyton CG Bier AM Donlon TZ Osman F Bartels CM Shelef MA Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects. PLoS One . 2019;14(5):e0217221
[PubMed ID: 31136605]
Holmes CL Shim D Kernien J Johnson CJ Nett JE Shelef MA Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases. J Immunol Res . 2019;2019:2160192
[PubMed ID: 30993117]
Damgaard D Bawadekar M Senolt L Stensballe A Shelef MA Nielsen CH Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3. PLoS One . 2018;13(8):e0203214
[PubMed ID: 30161253]
Rebernick R Fahmy L Glover C Bawadekar M Shim D Holmes CL Rademacher N Potluri H Bartels CM Shelef MA DNA Area and NETosis Analysis (DANA): a High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images. Biol Proced Online . 2018;20:7
[PubMed ID: 29618953]
Sun B Dwivedi N Bechtel TJ Paulsen JL Muth A Bawadekar M Li G Thompson PR Shelef MA Schiffer CA Weerapana E Ho IC Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα. Sci Immunol . 2017 Jun 9;2(12)
[PubMed ID: 28783661]
Bawadekar M Shim D Johnson CJ Warner TF Rebernick R Damgaard D Nielsen CH Pruijn GJM Nett JE Shelef MA Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation. J Autoimmun . 2017 Jun;80:39-47
[PubMed ID: 28188029]
Bawadekar M Gendron-Fitzpatrick A Rebernick R Shim D Warner TF Nicholas AP Lundblad LK Thompson PR Shelef MA Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation. Arthritis Res Ther . 2016 Jul 22;18(1):173
[PubMed ID: 27450561]
Shelef MA Bennin DA Yasmin N Warner TF Ludwig T Beggs HE Huttenlocher A Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis. Arthritis Res Ther . 2014 Oct 4;16(5):464
[PubMed ID: 25280866]
Shelef MA Sokolove J Robinson WH Huttenlocher A Reply: To PMID 24497204. Arthritis Rheumatol . 2014 Sep;66(9):2644-5
[PubMed ID: 24891318]
Shelef MA Sokolove J Lahey LJ Wagner CA Sackmann EK Warner TF Wang Y Beebe DJ Robinson WH Huttenlocher A Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol . 2014 Jun;66(6):1482-91
[PubMed ID: 24497204]
Shelef MA Tauzin S Huttenlocher A Neutrophil migration: moving from zebrafish models to human autoimmunity. Immunol Rev . 2013 Nov;256(1):269-81
[PubMed ID: 24117827]
Shelef MA Bennin DA Mosher DF Huttenlocher A Citrullination of fibronectin modulates synovial fibroblast behavior. Arthritis Res Ther . 2012 Nov 5;14(6):R240
[PubMed ID: 23127210]
Sackmann EK Berthier E Young EW Shelef MA Wernimont SA Huttenlocher A Beebe DJ Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood . 2012 Oct 4;120(14):e45-53
[PubMed ID: 22915642]