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Matthew W. Squire, MD, MS

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Matthew W. Squire, MD, MS Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Squire specializes in surgical care of the hip and knee. After his orthopedic surgical training, he completed a year of specialty fellowship training which focused on joint preservation surgery, routine and complex hip replacement, as well as routine and complex knee replacement. He is certified by the American Board of Orthopaedic Surgery (ABOS). He is a member of the American Association of Hip and Knee Surgeons. He is a member of the Arthritis Foundation. He is Co-Director of the Arthritis and Joint Replacement Program at the UW School of Medicine and Public Health.


Dr. Squire's surgical practice is split between hip and knee disorders. Dr. Squire routinely performs surgical care for young active patients (16 and older) as well as older patients. Dr. Squire's hip practice includes surgical care of hip labral injuries, femoral acetabular impingement, sports-related hip injuries, non-arthritic adolescent and adult hip pain, hip arthritis and failed hip replacements. The most common hip surgeries he performs are hip arthroscopy, open surgical hip dislocation, minimally-invasive and anterior hip replacement and revision (re-do) hip replacement surgery. Dr. Squire's knee practice includes surgical care of adult knee pain, knee arthritis and failed knee replacements. The most common knee surgeries he performs are knee replacement, partial knee replacement and revision (re-do) knee replacement surgery.


Dr. Squire attended the University of Iowa for his undergraduate degree (B.S.) in Exercise Science. He obtained his Biomedical Engineering Masters of Science degree from Rensselaer Polytechnic Institute in New York. He received his M.D. from the University of Iowa, where he was inducted into the medical school honor society. His orthopedic surgical training was completed at the University of Wisconsin Hospitals and Clinics. He then traveled to Charlotte, N.C., where he performed a year of specialty fellowship surgical training that focused on joint preservation surgery, complex and routine hip replacement surgery, as well as complex and routine knee replacement surgery (OrthoCarolina - Adult Reconstruction Fellowship).


In addition to hip and knee surgery, Dr. Squire is actively involved in orthopedic research and hip and knee replacement implant design, as well as education of medical students and orthopedic surgical trainees. Dr. Squire's research efforts on prevention and treatment of orthopedic infections, performance of hip and knee replacement implants and stem cells and cartilage restoration have been published and presented in many national and international journals and conferences. Dr. Squire served as the UW Hospitals and Clinics Orthopedic Program Director for seven years, during which time he was responsible for the selection of orthopedic surgery trainees (residents) as well as the design and oversight of their educational curriculum. Dr. Squire continues to be actively involved in hip and knee replacement implant design, holds multiple patents and is co-designer of an internationally distributed hip implant system.


Orthopedic Surgery

Anterior and Posterior Total Hip Replacement

Hip Arthroscopy

Hip Replacement or Resurfacing Revision

Knee Pain

Knee Replacement Revision

Orthopedic Joint Reconstruction and Replacement

Robotic Partial Knee Replacement

Total Hip Replacement (Arthroplasty)

Total Knee Replacement (Arthroplasty)


UW Health at The American Center
(608) 263-7540 | (844) 607-4800 | Map

UW School of Medicine and Public Health

Department of Orthopedics and Rehabilitation

Professional Certifications and Education

Board Certification Orthopedic Surgery
Fellowship Charlotte Orthopedic Specialists, Charlotte, NC
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Medical School University of Iowa Carver College of Medicine, Iowa City, IA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Squire’s research interests include prevention and treatment of orthopedic infection, hip resurfacing, robotic hip and knee surgery, design of hip and knee replacement devices, avascular necrosis, cartilage regeneration and non-destructive implant removal.

PubMed Articles
Bernatz JT Krueger DC Squire MW Illgen RL 2nd Binkley NC Anderson PA Unrecognized Osteoporosis Is Common in Patients With a Well-Functioning Total Knee Arthroplasty. J Arthroplasty . 2019 Oct;34(10):2347-2350
[PubMed ID: 31227302]
Bernatz JT Brooks AE Squire MW Illgen RI 2nd Binkley NC Anderson PA Osteoporosis Is Common and Undertreated Prior to Total Joint Arthroplasty. J Arthroplasty . 2019 Jul;34(7):1347-1353
[PubMed ID: 30992237]
Wang JF Lee MS Tsai TL Leiferman EM Trask DJ Squire MW Li WJ Bone Morphogenetic Protein-6 Attenuates Type 1 Diabetes Mellitus-Associated Bone Loss. Stem Cells Transl Med . 2019 Jun;8(6):522-534
[PubMed ID: 30784225]
Lee MS Wang J Yuan H Jiao H Tsai TL Squire MW Li WJ Endothelin-1 differentially directs lineage specification of adipose- and bone marrow-derived mesenchymal stem cells. FASEB J . 2019 Jan;33(1):996-1007
[PubMed ID: 30096039]
Bishop AR Kim S Squire MW Rose WE Ploeg HL Vancomycin elution, activity and impact on mechanical properties when added to orthopedic bone cement. J Mech Behav Biomed Mater . 2018 Nov;87:80-86
[PubMed ID: 30048880]
Bishop AR Kim S Squire M Rose WE Ploeg HL Data for vancomycin elution, activity and impact on mechanical properties when incorporated into orthopedic bone cement. Data Brief . 2018 Oct;20:14-19
[PubMed ID: 30101160]
Slane J Gietman B Squire M Antibiotic elution from acrylic bone cement loaded with high doses of tobramycin and vancomycin. J Orthop Res . 2018 Apr;36(4):1078-1085
[PubMed ID: 28876459]
Walczak BE Nies MS Trask DJ Hetzel S Roney PJ Squire MW Baer GS Osteochondral Graft Size Is Significantly Associated With Increased Force and Decreased Chondrocyte Viability. Am J Sports Med . 2018 Mar;46(3):623-631
[PubMed ID: 29328886]
Slane J Vivanco JF Squire M Ploeg HL Characterization of the quasi-static and viscoelastic properties of orthopaedic bone cement at the macro and nanoscale. J Biomed Mater Res B Appl Biomater . 2017 Aug;105(6):1461-1468
[PubMed ID: 27087200]
Tsai TL Wang B Squire MW Guo LW Li WJ Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling. Stem Cell Res Ther . 2015 May 1;6:88
[PubMed ID: 25998005]
Slane J Vivanco J Rose W Ploeg HL Squire M Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles. Mater Sci Eng C Mater Biol Appl . 2015 Mar;48:188-96
[PubMed ID: 25579913]
Brown PT Squire MW Li WJ Characterization and evaluation of mesenchymal stem cells derived from human embryonic stem cells and bone marrow. Cell Tissue Res . 2014 Oct;358(1):149-64
[PubMed ID: 24927918]
Slane J Vivanco J Ebenstein D Squire M Ploeg HL Multiscale characterization of acrylic bone cement modified with functionalized mesoporous silica nanoparticles. J Mech Behav Biomed Mater . 2014 Sep;37:141-52
[PubMed ID: 24911668]
Slane JA Vivanco JF Rose WE Squire MW Ploeg HL The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement. Mater Sci Eng C Mater Biol Appl . 2014 Sep;42:168-76
[PubMed ID: 25063107]
Slane J Vivanco J Meyer J Ploeg HL Squire M Modification of acrylic bone cement with mesoporous silica nanoparticles: effects on mechanical, fatigue and absorption properties. J Mech Behav Biomed Mater . 2014 Jan;29:451-61
[PubMed ID: 24211354]
Squire MW Technologically enhanced total knee replacement: is the juice worth the squeeze? AJR Am J Roentgenol . 2013 Sep;201(3):W451-2
[PubMed ID: 23971476]
Sheehy AM Benca J Glinberg SL Li Z Nautiyal A Anderson PA Squire MW Coursin DB Preoperative "NPO" as an opportunity for diabetes screening. J Hosp Med . 2012 Oct;7(8):611-6
[PubMed ID: 22887757]
Squire MW Imaging of metal-on-metal hip prostheses. AJR Am J Roentgenol . 2011 Sep;197(3):556-7
[PubMed ID: 21862796]
Squire MW Della Valle CJ Parvizi J Preoperative diagnosis of periprosthetic joint infection: role of aspiration. AJR Am J Roentgenol . 2011 Apr;196(4):875-9
[PubMed ID: 21427339]
Burgers T Mason J Squire M Ploeg HL Time-dependent fixation and implantation forces for a femoral knee component--an in vitro study. Med Eng Phys . 2010 Nov;32(9):968-73
[PubMed ID: 20674458]