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Matthew W. Squire, MD, MS

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Matthew W. Squire, MD, MS Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Squire is an internationally known UW Health joint replacement surgeon. He has performed over 6,000 joint replacement surgeries since starting his orthopedic practice in 2004. In the last 5 years he has performed 3,000 hip and knee replacement surgeries, one of the highest volumes in the Midwest.  He is fellowship trained and performed his hip and knee replacement training at the highly competitive and #1 ranked hip and knee replacement specialty training center known as OrthoCarolina. Graduates of the OrthoCarolina training center are known for their advanced knowledge of hip and knee replacement surgery, cutting-edge high impact research, and excellent surgical skills. His training laid the foundation for Dr. Squire’s current surgical practice by exposing him to the most advanced surgical technology and minimally invasive Hip and Knee Replacement techniques which he has utilized and refined over the last 15 years. 

Over his career, Dr. Squire has demonstrated an unparalleled track record of hip and knee replacement success.  He is recognized as a “destination surgeon” who treats patients traveling from all U.S. regions including Alaska and Hawaii as well as patients from other countries.  His extremely low complication and readmission rates, as well as his excellent patient satisfaction scores, have been instrumental in helping UW Hospitals achieve U.S. News and World Report’s top ranked Wisconsin Hospital status and UW Health’s Orthopedic Surgery Department top 20 ranking.  Additionally, his surgical quality metrics were a key part in UW Hospitals obtaining Medicare’s highest performance ranking (excellent-top 2%) for total joint replacement care.

Throughout his practice, Dr. Squire has been a proud member of the American Association of Hip and Knee Surgeons, American Academy of Orthopedic Surgeons, International Consortium for Prosthetic Joint Infection, as well as the Arthritis Foundation.  In conjunction with these organizations, Dr. Squire has been instrumental in developing “Best Practice” guidelines for hip and knee replacement surgeries.  By following the “Best Practice” guidelines of these organizations, Dr. Squire has been able to obtain the greatest results and success for his joint replacement patients. 

Dr. Squire is currently the Medical Director of the Wisconsin Arthritis Foundation.  As Medical Director, Dr. Squire intimately understands how hip and knee arthritis negatively impacts personal health, well-being, and quality of life. Dr. Squire is committed to expanding educational and treatment outreach to patients living with arthritis so that they may move and live without pain. As a hip and knee replacement surgeon and Arthritis Foundation Medical Director, he sees every day how hip and knee joint replacement can remarkably improve the quality of life for patients who suffer from arthritis.

Dr. Squire holds a master’s degree in Biomedical Engineering which gives him unique knowledge and insight as he performs stem cell and cartilage research as well as designs joint replacement implants and bone cement products. His research has been published in many international journals.  He is the co-designer of an internationally distributed hip replacement implant system and has multiple shared implant design patents.  He is co-director of the UW Health Joint Replacement Program where his primary duty is to ensure the highest possible quality of joint replacements performed at UW Health.  He is a member of the UW Health surgical site infection committee, using his expertise to help ensure the safest possible operating room environment for all UW Health patients.  He served as the UW Health orthopedic program director for seven years and twice has been awarded orthopedic surgery resident educator of the year.


Orthopedic Surgery

Anterior and Posterior Total Hip Replacement

Hip Arthroscopy

Hip Replacement or Resurfacing Revision

Knee Pain

Knee Replacement Revision

Orthopedic Joint Reconstruction and Replacement

Robotic Partial Knee Replacement

Total Hip Replacement (Arthroplasty)

Total Knee Replacement (Arthroplasty)


UW Health at The American Center
(608) 263-7540 | (844) 607-4800 | Map

UW School of Medicine and Public Health

Department of Orthopedics and Rehabilitation

Professional Certifications and Education

Board Certification Orthopedic Surgery
Fellowship Charlotte Orthopedic Specialists, Charlotte, NC
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Medical School University of Iowa Carver College of Medicine, Iowa City, IA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Squire’s research interests include prevention and treatment of orthopedic infection, hip resurfacing, robotic hip and knee surgery, design of hip and knee replacement devices, avascular necrosis, cartilage regeneration and non-destructive implant removal.

PubMed Articles
Kim S Bishop AR Squire MW Rose WE Ploeg HL Mechanical, elution, and antibacterial properties of simplex bone cement loaded with vancomycin. J Mech Behav Biomed Mater . 2020 Mar;103:103588
[PubMed ID: 32090917]
Bernatz JT Krueger DC Squire MW Illgen RL 2nd Binkley NC Anderson PA Unrecognized Osteoporosis Is Common in Patients With a Well-Functioning Total Knee Arthroplasty. J Arthroplasty . 2019 Oct;34(10):2347-2350
[PubMed ID: 31227302]
Bernatz JT Brooks AE Squire MW Illgen RI 2nd Binkley NC Anderson PA Osteoporosis Is Common and Undertreated Prior to Total Joint Arthroplasty. J Arthroplasty . 2019 Jul;34(7):1347-1353
[PubMed ID: 30992237]
Wang JF Lee MS Tsai TL Leiferman EM Trask DJ Squire MW Li WJ Bone Morphogenetic Protein-6 Attenuates Type 1 Diabetes Mellitus-Associated Bone Loss. Stem Cells Transl Med . 2019 Jun;8(6):522-534
[PubMed ID: 30784225]
Lee MS Wang J Yuan H Jiao H Tsai TL Squire MW Li WJ Endothelin-1 differentially directs lineage specification of adipose- and bone marrow-derived mesenchymal stem cells. FASEB J . 2019 Jan;33(1):996-1007
[PubMed ID: 30096039]
Bishop AR Kim S Squire MW Rose WE Ploeg HL Vancomycin elution, activity and impact on mechanical properties when added to orthopedic bone cement. J Mech Behav Biomed Mater . 2018 Nov;87:80-86
[PubMed ID: 30048880]
Bishop AR Kim S Squire M Rose WE Ploeg HL Data for vancomycin elution, activity and impact on mechanical properties when incorporated into orthopedic bone cement. Data Brief . 2018 Oct;20:14-19
[PubMed ID: 30101160]
Slane J Gietman B Squire M Antibiotic elution from acrylic bone cement loaded with high doses of tobramycin and vancomycin. J Orthop Res . 2018 Apr;36(4):1078-1085
[PubMed ID: 28876459]
Walczak BE Nies MS Trask DJ Hetzel S Roney PJ Squire MW Baer GS Osteochondral Graft Size Is Significantly Associated With Increased Force and Decreased Chondrocyte Viability. Am J Sports Med . 2018 Mar;46(3):623-631
[PubMed ID: 29328886]
Slane J Vivanco JF Squire M Ploeg HL Characterization of the quasi-static and viscoelastic properties of orthopaedic bone cement at the macro and nanoscale. J Biomed Mater Res B Appl Biomater . 2017 Aug;105(6):1461-1468
[PubMed ID: 27087200]
Tsai TL Wang B Squire MW Guo LW Li WJ Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling. Stem Cell Res Ther . 2015 May 1;6:88
[PubMed ID: 25998005]
Slane J Vivanco J Rose W Ploeg HL Squire M Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles. Mater Sci Eng C Mater Biol Appl . 2015 Mar;48:188-96
[PubMed ID: 25579913]
Brown PT Squire MW Li WJ Characterization and evaluation of mesenchymal stem cells derived from human embryonic stem cells and bone marrow. Cell Tissue Res . 2014 Oct;358(1):149-64
[PubMed ID: 24927918]
Slane J Vivanco J Ebenstein D Squire M Ploeg HL Multiscale characterization of acrylic bone cement modified with functionalized mesoporous silica nanoparticles. J Mech Behav Biomed Mater . 2014 Sep;37:141-52
[PubMed ID: 24911668]
Slane JA Vivanco JF Rose WE Squire MW Ploeg HL The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement. Mater Sci Eng C Mater Biol Appl . 2014 Sep;42:168-76
[PubMed ID: 25063107]
Slane J Vivanco J Meyer J Ploeg HL Squire M Modification of acrylic bone cement with mesoporous silica nanoparticles: effects on mechanical, fatigue and absorption properties. J Mech Behav Biomed Mater . 2014 Jan;29:451-61
[PubMed ID: 24211354]
Squire MW Technologically enhanced total knee replacement: is the juice worth the squeeze? AJR Am J Roentgenol . 2013 Sep;201(3):W451-2
[PubMed ID: 23971476]
Sheehy AM Benca J Glinberg SL Li Z Nautiyal A Anderson PA Squire MW Coursin DB Preoperative "NPO" as an opportunity for diabetes screening. J Hosp Med . 2012 Oct;7(8):611-6
[PubMed ID: 22887757]
Squire MW Imaging of metal-on-metal hip prostheses. AJR Am J Roentgenol . 2011 Sep;197(3):556-7
[PubMed ID: 21862796]
Squire MW Della Valle CJ Parvizi J Preoperative diagnosis of periprosthetic joint infection: role of aspiration. AJR Am J Roentgenol . 2011 Apr;196(4):875-9
[PubMed ID: 21427339]