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Loren C. Denlinger, MD, PhD
 

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Loren C. Denlinger, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Loren C. Denlinger, PhD, MD, earned his medical degree from the University of Wisconsin School of Medicine and Public Health (formerly UW Medical School), Madison, WI and completed his residency at UW Hospital and Clinics.

Specialties

Clinics

University Hospital
(608) 263-7203 | (800) 323-8942 | Map
University Hospital
(608) 263-8954 | (800) 323-8942 | Map
West Clinic
(608) 263-6180 | (800) 323-8942 | Map

Hospital Affiliation(s)

University Hospital
Veterans Hospital - Wm. S. Middleton Memorial

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Critical Care Medicine
Pulmonary Disease
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship University of Wisconsin Hospital and Clinics, Madison, WI
Medical School University of Wisconsin School of Medicine and Public Health (formerly UW Medical School), Madison, WI

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
PubMed Articles
Mummy DG Kruger SJ Zha W Sorkness RL Jarjour NN Schiebler ML Denlinger LC Evans MD Fain SB Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma. J Allergy Clin Immunol . 2018 Mar;141(3):1140-1141.e4
[PubMed ID: 29129582]
Shim SS Schiebler ML Evans MD Jarjour N Sorkness RL Denlinger LC Rodriguez A Wenzel S Hoffman EA Lin CL Gierada DS Castro M Fain SB National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Lumen area change (Delta Lumen) between inspiratory and expiratory multidetector computed tomography as a measure of severe outcomes in asthmatic patients. J Allergy Clin Immunol . 2018 Feb 10;
[PubMed ID: 29438772]
Zha W Kruger SJ Cadman RV Mummy DG Evans MD Nagle SK Denlinger LC Jarjour NN Sorkness RL Fain SB Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI. Acad Radiol . 2018 Feb;25(2):169-178
[PubMed ID: 29174189]
Wong-McGrath K Denlinger LC Bleecker ER Castro M Gaston B Israel E Jarjour NN Mauger DT Peters S Phillips BR Wenzel SE Fahy JV Peters MC National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest . 2018 Feb;153(2):378-386
[PubMed ID: 29080709]
Teague WG Phillips BR Fahy JV Wenzel SE Fitzpatrick AM Moore WC Hastie AT Bleecker ER Meyers DA Peters SP Castro M Coverstone AM Bacharier LB Ly NP Peters MC Denlinger LC Ramratnam S Sorkness RL Gaston BM Erzurum SC Comhair SAA Myers RE Zein J DeBoer MD Irani AM Israel E Levy B Cardet JC Phipatanakul W Gaffin JM Holguin F Fajt ML Aujla SJ Mauger DT Jarjour NN Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract . 2018 Mar - Apr;6(2):545-554.e4
[PubMed ID: 28866107]
Evans MD Esnault S Denlinger LC Jarjour NN Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients. J Allergy Clin Immunol . 2017 Dec 26;
[PubMed ID: 29103994]
Kelly EA Esnault S Liu LY Evans MD Johansson MW Mathur S Mosher DF Denlinger LC Jarjour NN Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma. Am J Respir Crit Care Med . 2017 Dec 1;196(11):1385-1395
[PubMed ID: 28862877]
Barkal LJ Procknow CL �lvarez-García YR Niu M Jiménez-Torres JA Brockman-Schneider RA Gern JE Denlinger LC Theberge AB Keller NP Berthier E Beebe DJ Microbial volatile communication in human organotypic lung models. Nat Commun . 2017 Nov 24;8(1):1770
[PubMed ID: 29176665]
Ricklefs I Barkas I Duvall MG Cernadas M Grossman NL Israel E Bleecker ER Castro M Erzurum SC Fahy JV Gaston BM Denlinger LC Mauger DT Wenzel SE Comhair SA Coverstone AM Fajt ML Hastie AT Johansson MW Peters MC Phillips BR Levy BD National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight . 2017 Jul 20;2(14)
[PubMed ID: 28724795]
Durack J Lynch SV Nariya S Bhakta NR Beigelman A Castro M Dyer AM Israel E Kraft M Martin RJ Mauger DT Rosenberg SR Sharp-King T White SR Woodruff PG Avila PC Denlinger LC Holguin F Lazarus SC Lugogo N Moore WC Peters SP Que L Smith LJ Sorkness CA Wechsler ME Wenzel SE Boushey HA Huang YJ National Heart, Lung and Blood Institute's “AsthmaNet�. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol . 2017 Jul;140(1):63-75
[PubMed ID: 27838347]
Shen ZJ Hu J Kashi VP Kelly EA Denlinger LC Lutchman K McDonald JG Jarjour NN Malter JS Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways. Am J Respir Crit Care Med . 2017 Jun 15;195(12):1576-1585
[PubMed ID: 28125291]
Denlinger LC Phillips BR Ramratnam S Ross K Bhakta NR Cardet JC Castro M Peters SP Phipatanakul W Aujla S Bacharier LB Bleecker ER Comhair SA Coverstone A DeBoer M Erzurum SC Fain SB Fajt M Fitzpatrick AM Gaffin J Gaston B Hastie AT Hawkins GA Holguin F Irani AM Israel E Levy BD Ly N Meyers DA Moore WC Myers R Opina MT Peters MC Schiebler ML Sorkness RL Teague WG Wenzel SE Woodruff PG Mauger DT Fahy JV Jarjour NN National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med . 2017 Feb 1;195(3):302-313
[PubMed ID: 27556234]
Denlinger LC King TS Cardet JC Craig T Holguin F Jackson DJ Kraft M Peters SP Ross K Sumino K Boushey HA Jarjour NN Wechsler ME Wenzel SE Castro M Avila PC NHLBI AsthmaNet Investigators. Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. Am J Respir Crit Care Med . 2016 Mar 15;193(6):634-41
[PubMed ID: 26540136]
Levy BD Noel PJ Freemer MM Cloutier MM Georas SN Jarjour NN Ober C Woodruff PG Barnes KC Bender BG Camargo CA Jr Chupp GL Denlinger LC Fahy JV Fitzpatrick AM Fuhlbrigge A Gaston BM Hartert TV Kolls JK Lynch SV Moore WC Morgan WJ Nadeau KC Ownby DR Solway J Szefler SJ Wenzel SE Wright RJ Smith RA Erzurum SC Future Research Directions in Asthma. An NHLBI Working Group Report. Am J Respir Crit Care Med . 2015 Dec 1;192(11):1366-72
[PubMed ID: 26305520]
Schwantes EA Denlinger LC Evans MD Gern JE Jarjour NN Mathur SK Severity of virus-induced asthma symptoms is inversely related to resolution IFN-λ expression. J Allergy Clin Immunol . 2015 Jun;135(6):1656-9
[PubMed ID: 25784275]
Burnham ME Esnault S Roti Roti EC Bates ME Bertics PJ Denlinger LC Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils. PLoS One . 2014;9(8):e103122
[PubMed ID: 25121926]
Castro M King TS Kunselman SJ Cabana MD Denlinger L Holguin F Kazani SD Moore WC Moy J Sorkness CA Avila P Bacharier LB Bleecker E Boushey HA Chmiel J Fitzpatrick AM Gentile D Hundal M Israel E Kraft M Krishnan JA LaForce C Lazarus SC Lemanske R Lugogo N Martin RJ Mauger DT Naureckas E Peters SP Phipatanakul W Que LG Sheshadri A Smith L Solway J Sullivan-Vedder L Sumino K Wechsler ME Wenzel S White SR Sutherland ER National Heart, Lung, and Blood Institute’s AsthmaNet. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA . 2014 May;311(20):2083-91
[PubMed ID: 24838406]
Karta MR Wickert LE Curran CS Gavala ML Denlinger LC Gern JE Bertics PJ Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol . 2014 Apr;133(4):1227-1230.e4
[PubMed ID: 24529411]
Esnault S Kelly EA Johansson MW Liu LY Han ST Akhtar M Sandbo N Mosher DF Denlinger LC Mathur SK Malter JS Jarjour NN Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines. Clin Immunol . 2014 Jan;150(1):90-100
[PubMed ID: 24333536]
Burnham ME Koziol-White CJ Esnault S Bates ME Evans MD Bertics PJ Denlinger LC Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression. J Immunol . 2013 Sep 15;191(6):2900-6
[PubMed ID: 23956426]