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L. Lee Eckhardt, MD close
L. Lee Eckhardt, MD

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L. Lee Eckhardt, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Lee Eckhardt is a clinical cardiac electrophysiologist who is board certified in Internal Medicine (ABIM), cardiovascular diseases (ABIM) and clinical cardiac electrophysiology. Dr. Eckhardt practices clinical cardiac electrophysiology and is co-director of the Inherited Arrhythmias Clinic.



University Hospital
(608) 263-1530 | (800) 323-8942 | Map
University Hospital
(608) 263-1530 | (800) 323-8942 | Map
Research Park Clinic
(608) 263-1530 | (800) 323-8942 | Map

Hospital Affiliation(s)

University Hospital
UnityPoint Health - Meriter

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Cardiovascular Medicine
Clinical Cardiac Electrophysiology
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Brigham and Women's Hospital, Boston, MA
Residency Georgetown University Medical Center, Washington, DC
Medical School George Washington University School of Medicine and Health Sciences, Washington, D.C.

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Eckhardt’s research interests are related to the cellular mechanisms of inherited arrhythmia syndromes and cellular electrophysiology.

PubMed Articles
Vaidyanathan R Van Ert H Haq KT Morotti S Esch S McCune EC Grandi E Eckhardt LL Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias. Circ Arrhythm Electrophysiol . 2018 Jan;11(1):e005800
[PubMed ID: 29326130]
Kalscheur MM Kipp RT Tattersall MC Mei C Buhr KA DeMets DL Field ME Eckhardt LL Page CD Machine Learning Algorithm Predicts Cardiac Resynchronization Therapy Outcomes: Lessons From the COMPANION Trial. Circ Arrhythm Electrophysiol . 2018 Jan;11(1):e005499
[PubMed ID: 29326129]
Kipp R Young N Barnett A Kopp D Leal MA Eckhardt LL Teelin T Hoffmayer KS Wright J Field M Injectable loop recorder implantation in an ambulatory setting by advanced practice providers: Analysis of outcomes. Pacing Clin Electrophysiol . 2017 Sep;40(9):982-985
[PubMed ID: 28691385]
Eckhardt LL Makielski JC Complexity of AF genetic susceptibility begets complexity of interpretation. Heart Rhythm . 2017 Feb;14(2):292-293
[PubMed ID: 27825974]
Van Ert HA McCune EC Orland KM Maginot KR Von Bergen NH January CT Eckhardt LL Flecainide treats a novel <i>KCNJ2</i> mutation associated with Andersen-Tawil syndrome. HeartRhythm Case Rep . 2017 Feb;3(2):151-154
[PubMed ID: 28491792]
Vaidyanathan R Markandeya YS Kamp TJ Makielski JC January CT Eckhardt LL IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes. Am J Physiol Heart Circ Physiol . 2016 Jun 1;310(11):H1611-21
[PubMed ID: 27059077]
Eckhardt LL Monomorphic ventricular tachycardia in Brugada syndrome: True-true but related? Heart Rhythm . 2016 Mar;13(3):683-5
[PubMed ID: 26632641]
Van Wagoner DR Piccini JP Albert CM Anderson ME Benjamin EJ Brundel B Califf RM Calkins H Chen PS Chiamvimonvat N Darbar D Eckhardt LL Ellinor PT Exner DV Fogel RI Gillis AM Healey J Hohnloser SH Kamel H Lathrop DA Lip GY Mehra R Narayan SM Olgin J Packer D Peters NS Roden DM Ross HM Sheldon R Wehrens XH Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. Heart Rhythm . 2015 Jan;12(1):e5-e29
[PubMed ID: 25460864]
Jones DK Liu F Vaidyanathan R Eckhardt LL Trudeau MC Robertson GA hERG 1b is critical for human cardiac repolarization. Proc Natl Acad Sci U S A . 2014 Dec 16;111(50):18073-7
[PubMed ID: 25453103]
Kalscheur MM Vaidyanathan R Orland KM Abozeid S Fabry N Maginot KR January CT Makielski JC Eckhardt LL KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia. Heart Rhythm . 2014 May;11(5):885-94
[PubMed ID: 24561538]
Vaidyanathan R Vega AL Song C Zhou Q Tan BH Berger S Makielski JC Eckhardt LL The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J Biol Chem . 2013 Jun 14;288(24):17472-80
[PubMed ID: 23640888]
Eckhardt LL Leal M Hollis Z Tanega J Alberte C Cryoablation for AVNRT: importance of ablation endpoint criteria. J Cardiovasc Electrophysiol . 2012 Jul;23(7):729-34
[PubMed ID: 22509957]
Eckhardt LL Teelin TC January CT Is ranolazine an antiarrhythmic drug? Am J Physiol Heart Circ Physiol . 2008 May;294(5):H1989-91
[PubMed ID: 18375723]
Eckhardt LL Farley AL Rodriguez E Ruwaldt K Hammill D Tester DJ Ackerman MJ Makielski JC KCNJ2 mutations in arrhythmia patients referred for LQT testing: a mutation T305A with novel effect on rectification properties. Heart Rhythm . 2007 Mar;4(3):323-9
[PubMed ID: 17341397]
Rajamani S Anderson CL Valdivia CR Eckhardt LL Foell JD Robertson GA Kamp TJ Makielski JC Anson BD January CT Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr). Am J Physiol Heart Circ Physiol . 2006 Mar;290(3):H1278-88
[PubMed ID: 16227340]
Eckhardt LL Rajamani S January CT Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br J Pharmacol . 2005 May;145(1):3-4
[PubMed ID: 15711590]