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Jonathan C. Makielski, MD, FACC

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Jonathan C. Makielski, MD, FACC Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

A Fellow of the American College of Cardiology, Dr. Makielski is board certified in internal medicine and in the subspecialty of cardiovascular diseases (cardiology). Recognized as an excellent teacher both in clinical and scientific settings, Dr. Makielski formally lectures to graduate students in physiology, genetics, pharmacology and toxicology. Nationally, he has participated as a lecturer in numerous courses and tutorials. As a clinician-investigator, Dr. Makielski has developed a distinguished NIH-funded research career in molecular electrophysiology.


Cardiovascular Medicine


Research Park Clinic
(608) 263-1530 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Cardiovascular Disease
Fellowship University of Chicago Medical Center, Chicago, IL
Residency North Carolina Memorial Hospital, Chapel Hill, NC
Internship North Carolina Memorial Hospital, Chapel Hill, NC
Medical School University of Chicago Medical School, Chicago, IL

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Makielski 's research has been continuously funded by the NIH since 1985 and he is a leader in ion channels research employing molecular biological and electrophysiological methods. His interests include the genetic basis of arrhythmia, such as the Burgada syndrome and long QT syndrome, with a focus on the cardiac sodium channel. Dr. Makielski is also studying the ATP-dependent potassium channel and its role in ischemia and ischemic preconditioning in the heart.

PubMed Articles
Narichania AD Makielski JC Goldberger ZD A Singular Signature. Circulation . 2019 Nov 12;140(20):1681-1683
[PubMed ID: 31710520]
Aubert G Barefield DY Demonbreun AR Ramratnam M Fallon KS Warner JL Rossi AE Hadhazy M Makielski JC McNally EM Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. JACC Basic Transl Sci . 2019 Apr;4(2):251-268
[PubMed ID: 31061927]
Ramratnam M Kenny B Kyle JW Wiedmeyer B Hacker TA Barefield DY McNally EM Makielski JC Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function. Heliyon . 2018 Jul;4(7):e00677
[PubMed ID: 29998196]
Hu RM Tester DJ Li R Sun T Peterson BZ Ackerman MJ Makielski JC Tan BH Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5A mutation, N406K, found in LQT3 patients. Channels (Austin) . 2018;12(1):176-186
[PubMed ID: 29983085]
Huang L Tang S Chen Y Zhang L Yin K Wu Y Zheng J Wu Q Makielski JC Cheng J Molecular pathological study on LRRC10 in sudden unexplained nocturnal death syndrome in the Chinese Han population. Int J Legal Med . 2017 May;131(3):621-628
[PubMed ID: 28032242]
Cheng J Kyle JW Lang D Wiedmeyer B Guo J Yin K Huang L Vaidyanathan R Su T Makielski JC An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population. J Am Heart Assoc . 2017 Apr 3;6(4)
[PubMed ID: 28373245]
Cheng J Kyle JW Wiedmeyer B Lang D Vaidyanathan R Makielski JC Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current. Sci Rep . 2017 Feb 20;7:42953
[PubMed ID: 28218286]
Eckhardt LL Makielski JC Complexity of AF genetic susceptibility begets complexity of interpretation. Heart Rhythm . 2017 Feb;14(2):292-293
[PubMed ID: 27825974]
Zhang L Tester DJ Lang D Chen Y Zheng J Gao R Corliss RF Tang S Kyle JW Liu C Ackerman MJ Makielski JC Cheng J Does Sudden Unexplained Nocturnal Death Syndrome Remain the Autopsy-Negative Disorder: A Gross, Microscopic, and Molecular Autopsy Investigation in Southern China. Mayo Clin Proc . 2016 Nov;91(11):1503-1514
[PubMed ID: 27707468]
Vaidyanathan R Markandeya YS Kamp TJ Makielski JC January CT Eckhardt LL IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes. Am J Physiol Heart Circ Physiol . 2016 Jun 1;310(11):H1611-21
[PubMed ID: 27059077]
Zheng J Zhou F Su T Huang L Wu Y Yin K Wu Q Tang S Makielski JC Cheng J The biophysical characterization of the first SCN5A mutation R1512W identified in Chinese sudden unexplained nocturnal death syndrome. Medicine (Baltimore) . 2016 Jun;95(23):e3836
[PubMed ID: 27281089]
Zhao Q Chen Y Peng L Gao R Liu N Jiang P Liu C Tang S Quan L Makielski JC Cheng J Identification of rare variants of DSP gene in sudden unexplained nocturnal death syndrome in the southern Chinese Han population. Int J Legal Med . 2016 Mar;130(2):317-22
[PubMed ID: 26585738]
Makielski JC Late sodium current: A mechanism for angina, heart failure, and arrhythmia. Trends Cardiovasc Med . 2016 Feb;26(2):115-22
[PubMed ID: 26092781]
Makielski JC Kyle JW Late I(Na) in the Heart: Physiology, Pathology, and Pathways. Circulation . 2015 Aug 18;132(7):553-5
[PubMed ID: 26187181]
Kapplinger JD Giudicessi JR Ye D Tester DJ Callis TE Valdivia CR Makielski JC Wilde AA Ackerman MJ Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel. Circ Cardiovasc Genet . 2015 Aug;8(4):582-95
[PubMed ID: 25904541]
Yang KC Kyle JW Makielski JC Dudley SC Jr Mechanisms of sudden cardiac death: oxidants and metabolism. Circ Res . 2015 Jun 5;116(12):1937-55
[PubMed ID: 26044249]
Hu RM Tan BH Tester DJ Song C He Y Dovat S Peterson BZ Ackerman MJ Makielski JC Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis. PLoS One . 2015;10(4):e0124921
[PubMed ID: 25923670]
January CT Makielski JC In memoriam: Harry A. Fozzard, MD, April 22, 1931-December 9, 2014. Heart Rhythm . 2015 Apr;12(4):855
[PubMed ID: 25800155]
Lin EC Moungey BM Lim E Concannon SP Anderson CL Kyle JW Makielski JC Balijepalli SY January CT Mouse ERG K(+) channel clones reveal differences in protein trafficking and function. J Am Heart Assoc . 2014 Dec 11;3(6):e001491
[PubMed ID: 25497881]
Kyle JW Makielski JC Diseases caused by mutations in Na<sub>v</sub>1.5 interacting proteins. Card Electrophysiol Clin . 2014 Dec 1;6(4):797-809
[PubMed ID: 25395996]