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John P. Sheehan, MD

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John P. Sheehan, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Sheehan has extensive expertise in clotting issues, including clotting disorders, thrombotic disorders, hypercoagulable disorders and recurrent venous thromboembolism.



Bleeding Disorders

Bone Marrow Biopsy


Hematology (Leukemia, Lymphoma and Multiple Myeloma)

Hematology (non cancer)

Lumbar Puncture

Pediatric Hematology and Oncology


American Family Children's Hospital
(608) 890-9493 | (800) 323-8942 | Map
UW Carbone Cancer Center
(608) 265-1700 | (800) 323-8942 | Map
University Hospital
(608) 890-9493 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Fellowship Washington University Medical Center, St. Louis, MO
Residency University of Minnesota Affiliated Hospitals, Minneapolis, MN
Internship University of Minnesota Affiliated Hospitals, Minneapolis, MN
Medical School University of Missouri School of Medicine, Columbia, MO

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
PubMed Articles
Garnett ER Lomax JE Mohammed BM Gailani D Sheehan JP Raines RT Phenotype of ribonuclease 1 deficiency in mice. RNA . 2019 Aug;25(8):921-934
[PubMed ID: 31053653]
Plautz WE Sekhar Pilli VS Cooley BC Chattopadhyay R Westmark PR Getz T Paul D Bergmeier W Sheehan JP Majumder R Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis. Arterioscler Thromb Vasc Biol . 2018 Apr;38(4):816-828
[PubMed ID: 29419409]
Tanratana P Ellery P Westmark P Mast AE Sheehan JP Elevated Plasma Factor IXa Activity in Premenopausal Women on Hormonal Contraception. Arterioscler Thromb Vasc Biol . 2018 Jan;38(1):266-274
[PubMed ID: 29097362]
Chanakira A Westmark PR Ong IM Sheehan JP Tissue factor-factor VIIa complex triggers protease activated receptor 2-dependent growth factor release and migration in ovarian cancer. Gynecol Oncol . 2017 Apr;145(1):167-175
[PubMed ID: 28148395]
Nazeef M Sheehan JP New developments in the management of moderate-to-severe hemophilia B. J Blood Med . 2016;7:27-38
[PubMed ID: 27099538]
Misenheimer TM Sheehan JP The regulation of factor IXa by supersulfated low molecular weight heparin. Biochemistry . 2010 Nov 23;49(46):9997-10005
[PubMed ID: 20945941]
Buyue Y Sheehan JP Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite. Blood . 2009 Oct 1;114(14):3092-100
[PubMed ID: 19414859]
Buyue Y Whinna HC Sheehan JP The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis. Blood . 2008 Oct 15;112(8):3234-41
[PubMed ID: 18647957]
Misenheimer TM Buyue Y Sheehan JP The heparin-binding exosite is critical to allosteric activation of factor IXa in the intrinsic tenase complex: the role of arginine 165 and factor X. Biochemistry . 2007 Jul 3;46(26):7886-95
[PubMed ID: 17563121]
Sheehan JP Walke EN Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism. Blood . 2006 May 15;107(10):3876-82
[PubMed ID: 16672689]
Yuan QP Walke EN Sheehan JP The factor IXa heparin-binding exosite is a cofactor interactive site: mechanism for antithrombin-independent inhibition of intrinsic tenase by heparin. Biochemistry . 2005 Mar 8;44(9):3615-25
[PubMed ID: 15736971]
Sheehan JP Kobbervig CE Kirkpatrick HM Heparin inhibits the intrinsic tenase complex by interacting with an exosite on factor IXa. Biochemistry . 2003 Sep 30;42(38):11316-25
[PubMed ID: 14503882]