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J. Carter Ralphe, MD
 

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J. Carter Ralphe, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. J. Carter Ralphe is the chief of the Division of Pediatric Cardiology within the UW School of Medicine and Public Health and co-director of UW Health's Pediatric Heart Program. He is board certified in pediatric cardiology. Dr. Ralphe and Chief Pediatric Cardiothoracic Surgeon Petros Anagnostopoulos, MD, lead the comprehensive Pediatric Heart Program at American Family Children's Hospital. Dr. Ralphe’s clinical interests include diagnosis and treatment of congenital heart defects, acquired and familial forms of cardiomyopathy and pediatric heart failure.

Specialties

Pediatric Cardiovascular Medicine

Pediatric Heart Care

Clinics

American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map
Southwest Health Center
(608) 342-5060 | | Map
Aurora Children's Health (Oshkosh)
(920) 303-8700 | | Map

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatric Cardiology
Fellowship University of Iowa Hospital and Clinics, Iowa City, IA
Residency University of Iowa Hospital and Clinics, Iowa City, IA
Internship University of Iowa Hospital and Clinics, Iowa City, IA
Medical School State University of New York, Brooklyn, NY

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
Research

Dr. Ralphe's research interests include genetic forms of cardiomyopathy and the development of stem cell models to study human heart disease.


PubMed Articles
Zawacki A Dodge A Eickhoff J Sun W Marriott E Ralphe JC Peterson AL Novel Lipid Thresholds for Screening Predict the Need for Pharmacotherapy. J Pediatr . 2018 Nov;202:220-225.e2
[PubMed ID: 30172432]
Farrell E Armstrong AE Grimes AC Naya FJ de Lange WJ Ralphe JC Transcriptome Analysis of Cardiac Hypertrophic Growth in <i>MYBPC3</i>-Null Mice Suggests Early Responders in Hypertrophic Remodeling. Front Physiol . 2018;9:1442
[PubMed ID: 30410445]
Smelter DF de Lange WJ Cai W Ge Y Ralphe JC The HCM-linked W792R mutation in cardiac myosin-binding protein C reduces C6 FnIII domain stability. Am J Physiol Heart Circ Physiol . 2018 Jun 1;314(6):H1179-H1191
[PubMed ID: 29451820]
Zawacki AW Dodge A Woo KM Ralphe JC Peterson AL In pediatric familial hypercholesterolemia, lipoprotein(a) is more predictive than LDL-C for early onset of cardiovascular disease in family members. J Clin Lipidol . 2018 Nov - Dec;12(6):1445-1451
[PubMed ID: 30150142]
Kriegel AJ Gartz M Afzal MZ de Lange WJ Ralphe JC Strande JL Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. J Cardiovasc Transl Res . 2017 Jun;10(3):295-304
[PubMed ID: 28032312]
Fagbuyi DB Venkataraman S Ralphe JC Zuckerbraun NS Pitetti RD Lin Y Jeong K Saladino RA Manole MD Diastolic Hypotension, Troponin Elevation, and Electrocardiographic Changes Associated With the Management of Moderate to Severe Asthma in Children. Acad Emerg Med . 2016 Jul;23(7):816-22
[PubMed ID: 27129445]
Moss RL Fitzsimons DP Ralphe JC Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium. Circ Res . 2015 Jan 2;116(1):183-92
[PubMed ID: 25552695]
De Lange WJ Grimes AC Hegge LF Spring AM Brost TM Ralphe JC E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction. J Gen Physiol . 2013 Sep;142(3):241-55
[PubMed ID: 23980194]
Ralphe JC de Lange WJ 3D engineered cardiac tissue models of human heart disease: learning more from our mice. Trends Cardiovasc Med . 2013 Feb;23(2):27-32
[PubMed ID: 23295081]
Egan KR Ralphe JC Weinhaus L Maginot KR Just sinus bradycardia or something more serious? Case Rep Pediatr . 2013;2013:736164
[PubMed ID: 23476865]
de Lange WJ Grimes AC Hegge LF Ralphe JC Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. J Gen Physiol . 2013 Jan;141(1):73-84
[PubMed ID: 23277475]
Marriott E Ralphe JC An unexpected cause of chronic dysphonia in a 10-year-old boy. J Pediatr Health Care . 2009 Sep-Oct;23(5):327-32
[PubMed ID: 19720268]
Ralphe JC Pediatric cardiologists can accurately use physical examination to identify pathologic murmurs in neonates. J Pediatr . 2009 Jul;155(1):145
[PubMed ID: 19559303]