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Dai Yamanouchi, MD, PhD close
Dai Yamanouchi, MD, PhD

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Dai Yamanouchi, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Yamanouchi is certified by the Japanese Board of Surgery and is a board certified Fellow of the Japanese College of Angiology. His expertise includes treatments for aortic aneurysms, carotid disease, aortic dissection, peripheral arterial disease and other vascular disorders.


Vascular Surgery

Abdominal Aortic Aneurysm

Abdominal Aortic Aneurysm Repair


Aortic Aneursym

Aortic Aneurysm

Aortic Aneurysm Repair

Arm Angioplasty

Arteriorvenous Fistula


Balloon Angioplasty

Brachiocephalic Artery Disease

Carotid Artery Surgery

Carotid Disease

Carotid Stenosis


Deep Vein Thrombosis

Dialysis Access Surgery

Endovascular Graft Repair for Abdominal Aortic Aneurysm

Endovascular Graft Repair for Aortic Aneurysm

Foot Ulcers


Laser Therapy for Veins

Limb Preservation

Limb Salvage

Limb Salvage Surgery

Lower Extremity Bypass Surgery

Mesenteric Artery Disease

Minimal Incision Phlebectomy

Minimally Invasive Abdominal Aortic Aneurysm Repair

Minimally Invasive Aortic Aneurysm Repair

Peripheral Arterial Disease

Peripheral Bypass Surgery

Radiofrequency Ablation for Vein Conditions

Renal Artery Disease

Sclerotherapy for Veins

Subclavian Artery Disease

Subclavian Vein Occlusion

Superior Vena Cava Syndrome

Thoracic Outlet Syndrome

Treatment for Spider Veins or Varicose Veins

Vascular and Endovascular Surgery

Venous Disease

Venous Stasis Disease

Visceral Angioplasty


West Clinic
(608) 263-8915 | (800) 323-8942 | Map
1 S. Park Clinic
(608) 287-2100 | (888) 703-2778 | Map
Stoughton Clinic
(608) 877-2660 | | Map
UW Health at The American Center
(608) 440-6300 | (844) 607-4800 | Map

Hospital Affiliation(s)

University Hospital
UnityPoint Health - Meriter

UW School of Medicine and Public Health

Department of Surgery

Professional Certifications and Education


Vascular Surgery,  Nagoya University Hospital, Japan

Advanced Endovascular Surgery,  University of Wisconsin Hospital and Clinics, Madison, WI

Residency Gunma University Hospital, Japan
Saiseikai Maebashi Hospital, Japan
Internship Gunma University Hospital, Japan
Medical School Gunma University, Maebashi, Japan

Languages Spoken

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Yamanouchi's research interests include the pathogenesis of abdominal aortic aneurysm and restenosis after angioplasty, including balloon angioplasty and stenting. He is also devoted to the development of novel materials for vascular bypass graft and gene delivery methods to treat patients who suffer from peripheral arterial disease.

PubMed Articles
Iijima M Gombodorj N Tachibana Y Tachibana K Yokobori T Honma K Nakano T Asao T Kuwahara R Aoyama K Yasuda H Kelly M Kuwano H Yamanouchi D Development of single nanometer-sized ultrafine oxygen bubbles to overcome the hypoxia-induced resistance to radiation therapy via the suppression of hypoxia-inducible factor‑1α. Int J Oncol . 2018 Mar;52(3):679-686
[PubMed ID: 29393397]
Leung AD Yamanouchi D Osteoclastogenesis in Abdominal Aortic Aneurysms: A new therapeutic target. Curr Drug Targets . 2017 Sep 25;
[PubMed ID: 28950811]
Kurihara C Tanaka T Yamanouchi D Hyperglycemia attenuates receptor activator of NF-κB ligand-induced macrophage activation by suppressing insulin signaling. J Surg Res . 2017 Jun 15;214:168-175
[PubMed ID: 28624040]
Tanaka T Takei Y Zaima N Moriyama T Yamanouchi D Hyperglycemia Suppresses RANKL-Induced Osteoclast Differentiation through LXRβ Expression in RAW264.7 Cells. J Nutr Sci Vitaminol (Tokyo) . 2017;63(1):28-34
[PubMed ID: 28367923]
Takei Y Tanaka T Kent KC Yamanouchi D Osteoclastogenic Differentiation of Macrophages in the Development of Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol . 2016 Sep;36(9):1962-71
[PubMed ID: 27386936]
Wiseman JT Fernandes-Taylor S Gunter R Barnes ML Saunders RS Rathouz PJ Yamanouchi D Kent KC Inter-rater agreement and checklist validation for postoperative wound assessment using smartphone images in vascular surgery. J Vasc Surg Venous Lymphat Disord . 2016 Jul;4(3):320-328.e2
[PubMed ID: 27318052]
Tanaka T Takei Y Yamanouchi D Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation. J Am Heart Assoc . 2016 Mar 28;5(3):e003062
[PubMed ID: 27021877]
Tanaka T Moriyama T Kawamura Y Yamanouchi D Puerarin Suppresses Macrophage Activation via Antioxidant Mechanisms in a CaPO<sub>4</sub>-Induced Mouse Model of Aneurysm. J Nutr Sci Vitaminol (Tokyo) . 2016;62(6):425-431
[PubMed ID: 28202848]
Gupta PK Smith BK Yamanouchi D Case Report of Percutaneous Retrograde Transcollateral Recanalization of the Superior Mesenteric Artery via the Celiac Artery for Acute Mesenteric Ischemia. Medicine (Baltimore) . 2015 Dec;94(50):e2036
[PubMed ID: 26683911]
Gupta PK Engelbert TL Ramanan B Fang X Yamanouchi D Hoch JR Acher CW Postdischarge outcomes after endovascular abdominal aortic aneurysm repair. J Vasc Surg . 2014 Apr;59(4):903-8
[PubMed ID: 24360236]
Takayama T Yamanouchi D Aneurysmal disease: the abdominal aorta. Surg Clin North Am . 2013 Aug;93(4):877-91, viii
[PubMed ID: 23885935]
Matsumura JS Yamanouchi D Goldstein JA Pollock CW Bosiers M Schultz GA Scheinert D Rocha-Singh KJ The United States StuDy for EvalUating EndovasculaR TreAtments of Lesions in the Superficial Femoral Artery and Proximal Popliteal By usIng the Protégé EverfLex NitInol STent SYstem II (DURABILITY II). J Vasc Surg . 2013 Jul;58(1):73-83.e1
[PubMed ID: 23642924]
Yamanouchi D Oshitari T Nakamura Y Yotsukura J Asanagi K Baba T Nizawa T Kishimoto T Yonemori Y Ota S Yamamoto S Primary neuroendocrine carcinoma of ocular adnexa. Case Rep Ophthalmol Med . 2013;2013:281351
[PubMed ID: 24294530]
Kurosawa K Matsumura JS Yamanouchi D Current status of medical treatment for abdominal aortic aneurysm. Circ J . 2013;77(12):2860-6
[PubMed ID: 24161907]
Morgan S Yamanouchi D Harberg C Wang Q Keller M Si Y Burlingham W Seedial S Lengfeld J Liu B Elevated protein kinase C-δ contributes to aneurysm pathogenesis through stimulation of apoptosis and inflammatory signaling. Arterioscler Thromb Vasc Biol . 2012 Oct;32(10):2493-502
[PubMed ID: 22879584]
Yamanouchi D Morgan S Stair C Seedial S Lengfeld J Kent KC Liu B Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm model. J Vasc Surg . 2012 Aug;56(2):455-61
[PubMed ID: 22560311]
Suwanabol PA Seedial SM Shi X Zhang F Yamanouchi D Roenneburg D Liu B Kent KC Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways. J Vasc Surg . 2012 Aug;56(2):446-54
[PubMed ID: 22521802]
Matsumura JS Gray W Chaturvedi S Yamanouchi D Peng L Verta P Results of carotid artery stenting with distal embolic protection with improved systems: Protected Carotid Artery Stenting in Patients at High Risk for Carotid Endarterectomy (PROTECT) trial. J Vasc Surg . 2012 Apr;55(4):968-976.e5
[PubMed ID: 22236885]
Yamanouchi D Takei Y Komori K Balanced mineralization in the arterial system: possible role of osteoclastogenesis/osteoblastogenesis in abdominal aortic aneurysm and stenotic disease. Circ J . 2012;76(12):2732-7
[PubMed ID: 23117745]
Zhang F Banker G Liu X Suwanabol PA Lengfeld J Yamanouchi D Kent KC Liu B The novel function of advanced glycation end products in regulation of MMP-9 production. J Surg Res . 2011 Dec;171(2):871-6
[PubMed ID: 20638679]