Craig T. January, MD, PhD, FACC close
Craig T. January, MD, PhD, FACC

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Craig T. January, MD, PhD, FACC Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. January is a clinician/scientist whose pioneering research has investigated the role of the L-type calcium channel in potentially lethal cardiac arrhythmias. He also investigates the molecular mechanisms of the congenital and acquired long QT syndromes that cause abnormalities of the heart’s electrical system to provoke cardiac arrhythmias and sudden cardiac death. Dr. January is a Fellow of the American College of Cardiology and member of several societies, including the American Heart Association and Wisconsin Heart Association. He has served extensively on peer review panels, including several National Institutes of Health Cardiovascular Study Sections, national American Heart Association review sections and VA merit review panels.


Cardiovascular Medicine

Cardiac Arrest Prevention Program

Inherited Arrhythmias


University Hospital
(608) 263-1530 | (800) 323-8942 | Map
University Hospital
(608) 263-1530 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Cardiovascular Disease
Fellowship University of Chicago Medical Center, Chicago, IL
Residency University of Chicago Medical Center, Chicago, IL
Internship University of Chicago Medical Center, Chicago, IL
Medical School University of Iowa, Iowa City, IA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. January’s research focuses on understanding basic mechanisms of cardiac arrhythmias, and he has worked extensively in drug-induced and inherited arrhythmia mechanisms. His laboratory has been instrumental in defining how mutations in cardiac ion channel genes, including the HERG potassium channel gene, lead to the congenital long QT syndrome, and on potential new therapies for this disease.

PubMed Articles
Qile M Ji Y Golden TD Houtman MJC Romunde F Fransen D van Ham WB IJzerman AP January CT Heitman LH Stary-Weinzinger A Delisle BP van der Heyden MAG LUF7244 plus Dofetilide Rescues Aberrant K<sub>v</sub>11.1 Trafficking and Produces Functional I<sub>Kv11.1</sub>. Mol Pharmacol . 2020 Jun;97(6):355-364
[PubMed ID: 32241959]
Kamp TJ Hamdan MH January CT Chloroquine or Hydroxychloroquine for COVID-19: Is Cardiotoxicity a Concern? J Am Heart Assoc . 2020 May 28;:e016887
[PubMed ID: 32463308]
Mellor GJ Panwar P Lee AK Steinberg C Hathaway JA Bartels K Christian S Balaji S Roberts JD Simpson CS Boczek NJ Tester DJ Radbill AE Mok NS Hamilton RM Kaufman ES Eugenio PL Weiss R January C McDaniel GM Leather RA Erickson C Falik S Behr ER Wilde AAM Sanatani S Ackerman MJ Van Petegem F Krahn AD Laksman Z Type 8 long QT syndrome: pathogenic variants in CACNA1C-encoded Cav1.2 cluster in STAC protein binding site. Europace . 2019 Nov 1;21(11):1725-1732
[PubMed ID: 31408100]
Wright JM January CT Atrial Fibrillation and Anticoagulation: One Size Fits All? Ann Intern Med . 2018 Oct 16;169(8):575-576
[PubMed ID: 30264144]
Hall AR Anderson CL Smith JL Mirshahi T Elayi CS January CT Delisle BP Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2. Front Physiol . 2018;9:584
[PubMed ID: 29875689]
Smith JL Tester DJ Hall AR Burgess DE Hsu CC Elayi SC Anderson CL January CT Luo JZ Hartzel DN Mirshahi UL Murray MF Mirshahi T Ackerman MJ Delisle BP Functional Invalidation of Putative Sudden Infant Death Syndrome-Associated Variants in the <i>KCNH2</i>-Encoded Kv11.1 Channel. Circ Arrhythm Electrophysiol . 2018 May;11(5):e005859
[PubMed ID: 29752375]
Delisle BP January CT Advancing precision medicine for the treatment of long-QT syndrome type 2: shedding light on lumacaftor. Eur Heart J . 2018 Apr 21;39(16):1456-1458
[PubMed ID: 29040441]
Van Ert HA McCune EC Orland KM Maginot KR Von Bergen NH January CT Eckhardt LL Flecainide treats a novel <i>KCNJ2</i> mutation associated with Andersen-Tawil syndrome. HeartRhythm Case Rep . 2017 Feb;3(2):151-154
[PubMed ID: 28491792]
Millard DC Strock CJ Carlson CB Aoyama N Juhasz K Goetze TA Stoelzle-Feix S Becker N Fertig N January CT Anson BD Ross JD Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes. Toxicol Sci . 2016 Nov;154(1):174-182
[PubMed ID: 27503387]
Smith JL Anderson CL Burgess DE Elayi CS January CT Delisle BP Molecular pathogenesis of long QT syndrome type 2. J Arrhythm . 2016 Oct;32(5):373-380
[PubMed ID: 27761161]
Vaidyanathan R Markandeya YS Kamp TJ Makielski JC January CT Eckhardt LL IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes. Am J Physiol Heart Circ Physiol . 2016 Jun 1;310(11):H1611-21
[PubMed ID: 27059077]
Yue Y Castrichini M Srivastava U Fabris F Shah K Li Z Qu Y El-Sherif N Zhou Z January C Hussain MM Jiang XC Sobie EA Wahren-Herlenius M Chahine M Capecchi PL Laghi-Pasini F Lazzerini PE Boutjdir M Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome. Circulation . 2015 Jul 28;132(4):230-40
[PubMed ID: 25995318]
January CT Makielski JC In memoriam: Harry A. Fozzard, MD, April 22, 1931-December 9, 2014. Heart Rhythm . 2015 Apr;12(4):855
[PubMed ID: 25800155]
Kamp TJ January CT Harry A. Fozzard, MD: 1931–2014. Circ Res . 2015 Feb 13;116(4):552-3
[PubMed ID: 25821880]
Lin EC Moungey BM Lim E Concannon SP Anderson CL Kyle JW Makielski JC Balijepalli SY January CT Mouse ERG K(+) channel clones reveal differences in protein trafficking and function. J Am Heart Assoc . 2014 Dec 11;3(6):e001491
[PubMed ID: 25497881]
Anderson CL Kuzmicki CE Childs RR Hintz CJ Delisle BP January CT Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome. Nat Commun . 2014 Nov 24;5:5535
[PubMed ID: 25417810]
Spencer CI Baba S Nakamura K Hua EA Sears MA Fu CC Zhang J Balijepalli S Tomoda K Hayashi Y Lizarraga P Wojciak J Scheinman MM Aalto-Setälä K Makielski JC January CT Healy KE Kamp TJ Yamanaka S Conklin BR Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports . 2014 Aug 12;3(2):269-81
[PubMed ID: 25254341]
Kalscheur MM Vaidyanathan R Orland KM Abozeid S Fabry N Maginot KR January CT Makielski JC Eckhardt LL KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia. Heart Rhythm . 2014 May;11(5):885-94
[PubMed ID: 24561538]
Su X Theberge AB January CT Beebe DJ Effect of microculture on cell metabolism and biochemistry: do cells get stressed in microchannels? Anal Chem . 2013 Feb 5;85(3):1562-70
[PubMed ID: 23327437]
Balijepalli SY Lim E Concannon SP Chew CL Holzem KE Tester DJ Ackerman MJ Delisle BP Balijepalli RC January CT Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating. Circulation . 2012 Dec 11;126(24):2809-18
[PubMed ID: 23136156]