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Craig T. January, MD, PhD, FACC close
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Craig T. January, MD, PhD, FACC
 

Craig T. January, MD, PhD, FACC Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. January is a clinician/scientist whose pioneering research has investigated the role of the L-type calcium channel in potentially lethal cardiac arrhythmias. He also investigates the molecular mechanisms of the congenital and acquired long QT syndromes that cause abnormalities of the heart’s electrical system to provoke cardiac arrhythmias and sudden cardiac death. Dr. January is a Fellow of the American College of Cardiology and member of several societies, including the American Heart Association and Wisconsin Heart Association. He has served extensively on peer review panels, including several National Institutes of Health Cardiovascular Study Sections, national American Heart Association review sections and VA merit review panels.

Specialties

Cardiovascular Medicine

UW Health Clinics

UW Hospital and Clinics
(608) 263-1530 | (800) 323-8942 | Map
UW Hospital and Clinics
(608) 263-1530 | (800) 323-8942 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)

Languages Spoken

English
Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Cardiovascular Disease
Fellowship University of Chicago Medical Center, Chicago, IL, Chicago, IL, Chicago, IL
Residency University of Chicago Medical Center, Chicago, IL, Chicago, IL, Chicago, IL
Internship University of Chicago Medical Center, Chicago, IL, Chicago, IL, Chicago, IL
Medical School University of Iowa, Iowa City, IA, 1976

Awards/Honors

Best Doctors® in America 2014

Best Doctors® in America 2013

Best Doctors® in America 2011


Programs & Conditions

Research

Dr. January’s research focuses on understanding basic mechanisms of cardiac arrhythmias, and he has worked extensively in drug-induced and inherited arrhythmia mechanisms. His laboratory has been instrumental in defining how mutations in cardiac ion channel genes, including the HERG potassium channel gene, lead to the congenital long QT syndrome, and on potential new therapies for this disease.


PubMed Articles
Kalscheur MM Vaidyanathan R Orland KM Abozeid S Fabry N Maginot KR January CT Makielski JC Eckhardt LL . KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia. Heart Rhythm. 2014 Feb 21;
[PubMed ID: 24561538]
Su X Theberge AB January CT Beebe DJ . Effect of microculture on cell metabolism and biochemistry: do cells get stressed in microchannels? Anal Chem. 2013 Feb 5;85(3):1562-70
[PubMed ID: 23327437]
Balijepalli SY Lim E Concannon SP Chew CL Holzem KE Tester DJ Ackerman MJ Delisle BP Balijepalli RC January CT . Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating. Circulation. 2012 Dec 11;126(24):2809-18
[PubMed ID: 23136156]
Ma J Guo L Fiene SJ Anson BD Thomson JA Kamp TJ Kolaja KL Swanson BJ January CT . High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2006-17
[PubMed ID: 21890694]
Cheng J Tester DJ Tan BH Valdivia CR Kroboth S Ye B January CT Ackerman MJ Makielski JC . The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680H to increase late Na current. Physiol Genomics. 2011 May 13;43(9):461-6
[PubMed ID: 21385947]
Best JM Foell JD Buss CR Delisle BP Balijepalli RC January CT Kamp TJ . Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels. Am J Physiol Cell Physiol. 2011 May;300(5):C1023-33
[PubMed ID: 21248079]
Su X Young EW Underkofler HA Kamp TJ January CT Beebe DJ . Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels. J Biomol Screen. 2011 Jan;16(1):101-11
[PubMed ID: 21131594]
Balijepalli SY Anderson CL Lin EC January CT . Rescue of mutated cardiac ion channels in inherited arrhythmia syndromes. J Cardiovasc Pharmacol. 2010 Aug;56(2):113-22
[PubMed ID: 20224422]
Lin EC Holzem KM Anson BD Moungey BM Balijepalli SY Tester DJ Ackerman MJ Delisle BP Balijepalli RC January CT . Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1842-9
[PubMed ID: 20363883]
Cheng J Van Norstrand DW Medeiros-Domingo A Valdivia C Tan BH Ye B Kroboth S Vatta M Tester DJ January CT Makielski JC Ackerman MJ . Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. Circ Arrhythm Electrophysiol. 2009 Dec;2(6):667-76
[PubMed ID: 20009079]
Eckhardt LL Teelin TC January CT . Is ranolazine an antiarrhythmic drug? Am J Physiol Heart Circ Physiol. 2008 May;294(5):H1989-91
[PubMed ID: 18375723]
Balijepalli RC Delisle BP Balijepalli SY Foell JD Slind JK Kamp TJ January CT . Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol. Channels (Austin). 2007 Jul-Aug;1(4):263-72
[PubMed ID: 18708743]
He JQ January CT Thomson JA Kamp TJ . Human embryonic stem cell-derived cardiomyocytes: drug discovery and safety pharmacology. Expert Opin Drug Discov. 2007 May;2(5):739-53
[PubMed ID: 23488962]
Rajamani S Anderson CL Valdivia CR Eckhardt LL Foell JD Robertson GA Kamp TJ Makielski JC Anson BD January CT . Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr). Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88
[PubMed ID: 16227340]
Anderson CL Delisle BP Anson BD Kilby JA Will ML Tester DJ Gong Q Zhou Z Ackerman MJ January CT . Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation. 2006 Jan 24;113(3):365-73
[PubMed ID: 16432067]
Delisle BP Slind JK Kilby JA Anderson CL Anson BD Balijepalli RC Tester DJ Ackerman MJ Kamp TJ January CT . Intragenic suppression of trafficking-defective KCNH2 channels associated with long QT syndrome. Mol Pharmacol. 2005 Jul;68(1):233-40
[PubMed ID: 15851652]
Eckhardt LL Rajamani S January CT . Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br J Pharmacol. 2005 May;145(1):3-4
[PubMed ID: 15711590]
Anson BD Weaver JG Ackerman MJ Akinsete O Henry K January CT Badley AD . Blockade of HERG channels by HIV protease inhibitors. Lancet. 2005 Feb 19-25;365(9460):682-6
[PubMed ID: 15721475]
Delisle BP Anson BD Rajamani S January CT . Biology of cardiac arrhythmias: ion channel protein trafficking. Circ Res. 2004 Jun 11;94(11):1418-28
[PubMed ID: 15192037]
Anson BD Ackerman MJ Tester DJ Will ML Delisle BP Anderson CL January CT . Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2434-41
[PubMed ID: 14975928]