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Christian M. Capitini, MD close
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Christian M. Capitini, MD
 

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Christian M. Capitini, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Christian Capitini graduated with an MD with Distinction in Research at the University of Rochester School of Medicine and Dentistry in 2002. He then completed a residency in Pediatrics at the University of Minnesota in 2005, where he was inducted into the Arnold P. Gold Foundation Humanism in Medicine Honor Society. Dr. Capitini then completed a fellowship in Pediatric Hematology/Oncology through the joint program of Johns Hopkins University/National Cancer Institute in 2008. He also served as Chief Fellow in the last year of fellowship. Dr. Capitini joined the faculty of the University of Wisconsin-Madison as an Assistant Professor in 2011. He is board certified in Pediatric Hematology/Oncology.

Specialties

Pediatric Hematology and Oncology

Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

Adrenocortical carcinoma

Aplastic Anemia

Astrocytoma

Ataxia-telengiectasia

Atypical Teratoid/Rhabdoid tumor

Bone Marrow Biopsy

Brain Stem Glioma

CAR T-cell Therapy (Pediatric)

Chemotherapy

Chronic Myeloid Leukemia

Congenital Hemolytic Anemias

Craniopharyngioma

Cyclic Neutropenia

Diamond-Blackfan Syndrome

Endocrine Tumors

Ependymoma

Ewing Sarcoma

Fanconi's Anemia

Germ Cell Tumors

Hemophagocytic Lymphohistiocytosis

Hemophilia A

Hemophilia B

Hepatoblastoma

Hereditary Spherocytosis

Hodgkin's Disease

I-131 MIBG (Metaiodobenzylguadine)

Immune Thrombocytopenc Purpura

Immunotherapy

Juvenile Myelomonocytic Leukemia

Kostmann Syndrome

Langerhans' Cell Histiocytosis

Lumbar Puncture

Medulloblastoma

Myelodysplastic Syndromes

Neuroblastoma

Neurocutaneous Syndrome

Neurofibromatosis

Non-Hodgkin Lymphomas

Optic Glioma

Osteosarcoma

Paroxysmal Nocturnal Hemoglobinuria

Pediatric Bleeding Disorders

Pediatric Bone Marrow Transplant

Pediatric Cancer

Pediatric Sickle Cell Disease

Retinoblastoma

Rhabdomyosarcoma

Schwanomatosis

Shwachman-Diamond Syndrome

Sturge-Weber Syndrome

Thalassemia Syndromes

Thrombophilia

Thyroid Tumors

Tuberous Sclerosis

Vascular malformations

Von Willebrand Disease

VonHippel-Lindau Disease

Wilms Tumor

Clinics

American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map
American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map

Hospital Affiliation(s)

American Family Children's Hospital
UnityPoint Health - Meriter

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatric Hematology-Oncology
Fellowship

Pediatric Hematology/Oncology, The Johns Hopkins Hospital, Baltimore, MD and National Cancer Institute, Bethesda, MD


Residency University of Minnesota Medical Center, Minneapolis, MN
Medical School University of Rochester School of Medicine and Dentistry, Rochester, NY

Languages Spoken

Spanish
Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
Research

Dr. Capitini focuses his research on using allogeneic bone marrow transplant to cure pediatric cancers. The goal of this research is two-fold: to improve graft-vs.-tumor effects using immunotherapies that have potential to be translated into the clinic, and to reduce or eliminate graft-versus-host-disease (GVHD) through modulation of antigen presenting cells. Ongoing laboratory work is combining NK cells expanded with costimulatory molecules and gamma (c) cytokines with antibodies to stimulate NK cell proliferation and activation against several pediatric tumors in the alloBMT setting. He is also developing MRI techniques to monitor NK cells in vivo. Clinically, Dr. Capitini is a site investigator for clinical trials studying chimeric antigen receptor (CAR)-modified T cells for relapsed leukemia. Learn more about Dr. Capitini's research


PubMed Articles
Forsberg MH Das A Saha K Capitini CM The potential of CAR T therapy for relapsed or refractory pediatric and young adult B-cell ALL. Ther Clin Risk Manag . 2018;14:1573-1584
[PubMed ID: 30233192]
Lieberman NAP DeGolier K Haberthur K Chinn H Moyes KW Bouchlaka MN Walker KL Capitini CM Crane CA An Uncoupling of Canonical Phenotypic Markers and Functional Potency of <i>Ex Vivo</i>-Expanded Natural Killer Cells. Front Immunol . 2018;9:150
[PubMed ID: 29456538]
Piscopo NJ Mueller KP Das A Hematti P Murphy WL Palecek SP Capitini CM Saha K Bioengineering Solutions for Manufacturing Challenges in CAR T Cells. Biotechnol J . 2018 Feb;13(2)
[PubMed ID: 28840981]
Wolfe AD Capitini CM Salamat SM DeSantes K Bradley KA Kennedy T Dehner LP Patel NJ Neck Rhabdoid Tumors: Clinical Features and Consideration of Autologous Stem Cell Transplant. J Pediatr Hematol Oncol . 2018 Jan;40(1):e50-e54
[PubMed ID: 28375943]
Bouchlaka MN Moffitt AB Kim J Kink JA Bloom DD Love C Dave S Hematti P Capitini CM Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models. Biol Blood Marrow Transplant . 2017 Jun;23(6):897-905
[PubMed ID: 28257800]
Bouchlaka MN Ludwig KD Gordon JW Kutz MP Bednarz BP Fain SB Capitini CM (19)F-MRI for monitoring human NK cells in vivo. Oncoimmunology . 2016 May;5(5):e1143996
[PubMed ID: 27467963]
Capitini CM Romero P JITC launches a new section: commentary and editorials. J Immunother Cancer . 2015;3:28
[PubMed ID: 26110058]
McDowell KA Hank JA DeSantes KB Capitini CM Otto M Sondel PM NK cell-based immunotherapies in Pediatric Oncology. J Pediatr Hematol Oncol . 2015 Mar;37(2):79-93
[PubMed ID: 25590232]
Capitini CM Nasholm NM Chien CD Larabee SM Qin H Song YK Klover PJ Hennighausen L Khan J Fry TJ Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD. Blood . 2014 Sep 18;124(12):1976-86
[PubMed ID: 25079358]
Shand JC Qin H Nasholm N Capitini CM Fry TJ Minor antigen distribution predicts site-specific graft-versus-tumor activity of adoptively transferred, minor antigen-specific CD8 T Cells. Biol Blood Marrow Transplant . 2014 Jan;20(1):26-36
[PubMed ID: 24141010]
Capitini CM Otto M DeSantes KB Sondel PM Immunotherapy in pediatric malignancies: current status and future perspectives. Future Oncol . 2014;10(9):1659-78
[PubMed ID: 25145434]
Lockridge JL Zhou Y Becker YA Ma S Kenney SC Hematti P Capitini CM Burlingham WJ Gendron-Fitzpatrick A Gumperz JE Mice engrafted with human fetal thymic tissue and hematopoietic stem cells develop pathology resembling chronic graft-versus-host disease. Biol Blood Marrow Transplant . 2013 Sep;19(9):1310-22
[PubMed ID: 23806772]
Capitini CM Redmond WL Shafer-Weaver KA Professional development session for early career scientists at SITC 2012. J Immunother Cancer . 2013;1:6
[PubMed ID: 25742323]
Capitini CM Nasholm NM Duncan BB Guimond M Fry TJ Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis. J Immunol . 2013 Feb 1;190(3):1351-9
[PubMed ID: 23275602]
Capitini CM Gottschalk S Brenner M Cooper LJ Handgretinger R Mackall CL Highlights of the second international conference on "Immunotherapy in Pediatric Oncology". Pediatr Hematol Oncol . 2011 Sep;28(6):459-60
[PubMed ID: 21854215]
Capitini CM Davis JP Larabee SM Herby S Nasholm NM Fry TJ Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination. Biol Blood Marrow Transplant . 2011 Jun;17(6):790-9
[PubMed ID: 21216299]
Temple LM Miyamoto DM Mehta M Capitini CM Von Stetina S Barnes HJ Christensen VL Horton JR Spears PA Orndorff PE Identification and characterization of two Bordetella avium gene products required for hemagglutination. Infect Immun . 2010 Jun;78(6):2370-6
[PubMed ID: 20351141]
Wayne AS Capitini CM Mackall CL Immunotherapy of childhood cancer: from biologic understanding to clinical application. Curr Opin Pediatr . 2010 Feb;22(1):2-11
[PubMed ID: 19952749]
Capitini CM Mackall CL Wayne AS Immune-based therapeutics for pediatric cancer. Expert Opin Biol Ther . 2010 Feb;10(2):163-78
[PubMed ID: 19947897]
Capitini CM Herby S Milliron M Anver MR Mackall CL Fry TJ Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect. Blood . 2009 May 14;113(20):5002-9
[PubMed ID: 19258593]