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Bruce S. Klein, MD
 

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Bruce S. Klein, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Klein is a Professor in the Department of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, at the University of Wisconsin School of Medicine and Public Health. He maintains a special research and clinical interest in systemic fungal infections and has pioneered efforts in molecular pathogenesis and immunology that have helped transform the discipline into a vibrant field of research. He has published more than 100 original articles, reviews and book chapters on this subject and is a world leader in this field.

 

Dr. Klein has served on a number of local, national and international committees, including as Chair of the University of Wisconsin-Madison Biological Sciences Divisional Committee for Tenure and Promotion and as a Charter or Ad Hoc member of several NIH study sections. He has served on the Medical School's NIH K30 Training Grant Advisory Board and the Research Advisory Committee in Pediatrics.

Specialties

Pediatric Infectious Diseases

Clinics

University Hospital
(608) 263-0946 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency The Johns Hopkins Hospital, Baltimore, MD
Internship The Johns Hopkins Hospital, Baltimore, MD
Medical School Boston University School of Medicine, Boston, MA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
Research

Dr. Klein received several career development awards from the NIH: a Physician Scientist Award, a First Award, and a Research Career Development Award. He is funded with several active NIH grants. He received one of NIH’s most coveted honors, a MERIT award, which provides 10 years of continuous funding to the most outstanding and productive NIH funded investigators. Dr. Klein was awarded the UW-Madison Hilldale Award in Biological Sciences by the University for his distinguished research achievements. He was elected Vice Chair (2012) and Chairman (2014) at the Inaugural Gordon Research Conference on Immunology of Fungal Diseases. He has been inducted into the Association of American Physicians, a national society of physician-scientist leaders.


PubMed Articles
Campuzano A Zhang H Ostroff GR Dos Santos Dias L Wüthrich M Klein BS Yu JJ Lara HH Lopez-Ribot JL Hung CY CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against <i>Coccidioides posadasii</i> Infection. J Immunol . 2020 Jun 15;204(12):3296-3306
[PubMed ID: 32358020]
Siqueira IM Wüthrich M Li M Wang H Las-Casas LO de Castro RJA Klein B Bocca AL Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage of experimental chromoblastomycosis. PLoS Negl Trop Dis . 2020 Jun;14(6):e0008386
[PubMed ID: 32542003]
Negoro PE Xu S Dagher Z Hopke A Reedy JL Feldman MB Khan NS Viens AL Alexander NJ Atallah NJ Scherer AK Dutko RA Jeffery J Kernien JF Fites JS Nett JE Klein BS Vyas JM Irimia D Sykes DB Mansour MK Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to <i>Candida</i> Species. mBio . 2020 May 12;11(3)
[PubMed ID: 32398316]
Fisher MC Gurr SJ Cuomo CA Blehert DS Jin H Stukenbrock EH Stajich JE Kahmann R Boone C Denning DW Gow NAR Klein BS Kronstad JW Sheppard DC Taylor JW Wright GD Heitman J Casadevall A Cowen LE Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture. mBio . 2020 May 5;11(3)
[PubMed ID: 32371596]
Dobson HE Dias LDS Kohn EM Fites S Wiesner DL Dileepan T Kujoth GC Abraham A Ostroff GR Klein BS Wüthrich M Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance. Mucosal Immunol . 2020 May;13(3):518-529
[PubMed ID: 31900406]
Wiesner DL Merkhofer RM Ober C Kujoth GC Niu M Keller NP Gern JE Brockman-Schneider RA Evans MD Jackson DJ Warner T Jarjour NN Esnault SJ Feldman MB Freeman M Mou H Vyas JM Klein BS Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe . 2020 Apr 8;27(4):614-628.e6
[PubMed ID: 32130954]
Merkhofer RM Klein BS Advances in Understanding Human Genetic Variations That Influence Innate Immunity to Fungi. Front Cell Infect Microbiol . 2020;10:69
[PubMed ID: 32185141]
McBride JA Gauthier GM Klein BS Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of <i>Blastomyces</i>. Virulence . 2019 Dec;10(1):801-809
[PubMed ID: 29532714]
Walsh NM Botts MR McDermott AJ Ortiz SC Wüthrich M Klein B Hull CM Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus. PLoS Pathog . 2019 Jun;15(6):e1007777
[PubMed ID: 31247052]
Merkhofer RM Jr O'Neill MB Xiong D Hernandez-Santos N Dobson H Fites JS Shockey AC Wuethrich M Pepperell CS Klein BS Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus. mBio . 2019 Jun 18;10(3)
[PubMed ID: 31213563]
Rocke TE Kingstad-Bakke B Wüthrich M Stading B Abbott RC Isidoro-Ayza M Dobson HE Dos Santos Dias L Galles K Lankton JS Falendysz EA Lorch JM Fites JS Lopera-Madrid J White JP Klein B Osorio JE Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus). Sci Rep . 2019 May 1;9(1):6788
[PubMed ID: 31043669]
Brandhorst TT Kean IRL Lawry SM Wiesner DL Klein BS Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity. Sci Rep . 2019 Mar 25;9(1):5047
[PubMed ID: 30911085]
Brandhorst TT Klein BS Uncertainty surrounding the mechanism and safety of the post-harvest fungicide fludioxonil. Food Chem Toxicol . 2019 Jan;123:561-565
[PubMed ID: 30458269]
Sharma A Lawry SM Klein BS Wang X Sherer NM Zumwalde NA Gumperz JE LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes. J Immunol . 2018 Oct 15;201(8):2452-2461
[PubMed ID: 30171164]
McDermott AJ Klein BS Helper T-cell responses and pulmonary fungal infections. Immunology . 2018 Oct;155(2):155-163
[PubMed ID: 29781185]
Nanjappa SG Mudalagiriyappa S Fites JS Suresh M Klein BS CBLB Constrains Inactivated Vaccine-Induced CD8<sup>+</sup> T Cell Responses and Immunity against Lethal Fungal Pneumonia. J Immunol . 2018 Sep 15;201(6):1717-1726
[PubMed ID: 30054317]
Sui P Wiesner DL Xu J Zhang Y Lee J Van Dyken S Lashua A Yu C Klein BS Locksley RM Deutsch G Sun X Pulmonary neuroendocrine cells amplify allergic asthma responses. Science . 2018 Jun 8;360(6393)
[PubMed ID: 29599193]
Fites JS Gui M Kernien JF Negoro P Dagher Z Sykes DB Nett JE Mansour MK Klein BS An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections. PLoS Pathog . 2018 May;14(5):e1007073
[PubMed ID: 29782541]
Hernández-Santos N Wiesner DL Fites JS McDermott AJ Warner T Wüthrich M Klein BS Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection. Cell Host Microbe . 2018 Apr 11;23(4):511-522.e5
[PubMed ID: 29576482]
Kujoth GC Sullivan TD Merkhofer R Lee TJ Wang H Brandhorst T Wüthrich M Klein BS CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis. mBio . 2018 Apr 3;9(2)
[PubMed ID: 29615501]