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Bruce S. Klein, MD

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Bruce S. Klein, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Klein is a Professor in the Department of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, at the University of Wisconsin School of Medicine and Public Health. He maintains a special research and clinical interest in systemic fungal infections and has pioneered efforts in molecular pathogenesis and immunology that have helped transform the discipline into a vibrant field of research. He has published more than 100 original articles, reviews and book chapters on this subject and is a world leader in this field.


Dr. Klein has served on a number of local, national and international committees, including as Chair of the University of Wisconsin-Madison Biological Sciences Divisional Committee for Tenure and Promotion and as a Charter or Ad Hoc member of several NIH study sections. He has served on the Medical School's NIH K30 Training Grant Advisory Board and the Research Advisory Committee in Pediatrics.


Pediatric Infectious Diseases


University Hospital
(608) 263-0946 | (800) 323-8942 | Map

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency The Johns Hopkins Hospital, Baltimore, MD
Internship The Johns Hopkins Hospital, Baltimore, MD
Medical School Boston University School of Medicine, Boston, MA

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Klein received several career development awards from the NIH: a Physician Scientist Award, a First Award, and a Research Career Development Award. He is funded with several active NIH grants. He received one of NIH’s most coveted honors, a MERIT award, which provides 10 years of continuous funding to the most outstanding and productive NIH funded investigators. Dr. Klein was awarded the UW-Madison Hilldale Award in Biological Sciences by the University for his distinguished research achievements. He was elected Vice Chair (2012) and Chairman (2014) at the Inaugural Gordon Research Conference on Immunology of Fungal Diseases. He has been inducted into the Association of American Physicians, a national society of physician-scientist leaders.

PubMed Articles
Brandhorst TT Klein BS Uncertainty surrounding the mechanism and safety of the post-harvest fungicide fludioxonil. Food Chem Toxicol . 2018 Nov 17;
[PubMed ID: 30458269]
Sharma A Lawry SM Klein BS Wang X Sherer NM Zumwalde NA Gumperz JE LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes. J Immunol . 2018 Oct 15;201(8):2452-2461
[PubMed ID: 30171164]
McDermott AJ Klein BS Helper T-cell responses and pulmonary fungal infections. Immunology . 2018 Oct;155(2):155-163
[PubMed ID: 29781185]
Nanjappa SG Mudalagiriyappa S Fites JS Suresh M Klein BS CBLB Constrains Inactivated Vaccine-Induced CD8<sup>+</sup> T Cell Responses and Immunity against Lethal Fungal Pneumonia. J Immunol . 2018 Sep 15;201(6):1717-1726
[PubMed ID: 30054317]
McBride JA Gauthier GM Klein BS Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of Blastomyces. Virulence . 2018 Aug 1;:1-9
[PubMed ID: 29532714]
Sui P Wiesner DL Xu J Zhang Y Lee J Van Dyken S Lashua A Yu C Klein BS Locksley RM Deutsch G Sun X Pulmonary neuroendocrine cells amplify allergic asthma responses. Science . 2018 Jun 8;360(6393)
[PubMed ID: 29599193]
Fites JS Gui M Kernien JF Negoro P Dagher Z Sykes DB Nett JE Mansour MK Klein BS An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections. PLoS Pathog . 2018 May;14(5):e1007073
[PubMed ID: 29782541]
Hernández-Santos N Wiesner DL Fites JS McDermott AJ Warner T Wüthrich M Klein BS Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection. Cell Host Microbe . 2018 Apr 11;23(4):511-522.e5
[PubMed ID: 29576482]
Kujoth GC Sullivan TD Merkhofer R Lee TJ Wang H Brandhorst T Wüthrich M Klein BS CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis. MBio . 2018 Apr 3;9(2)
[PubMed ID: 29615501]
McDermott AJ Tumey TA Huang M Hull CM Klein BS Inhaled Cryptococcus neoformans elicits allergic airway inflammation independent of Nuclear Factor Kappa B signalling in lung epithelial cells. Immunology . 2018 Apr;153(4):513-522
[PubMed ID: 29055116]
Kottom TJ Hebrink DM Jenson PE Marsolek PL Wüthrich M Wang H Klein B Yamasaki S Limper AH Dectin-2 Is a C-Type Lectin Receptor that Recognizes Pneumocystis and Participates in Innate Immune Responses. Am J Respir Cell Mol Biol . 2018 Feb;58(2):232-240
[PubMed ID: 28886250]
Garfoot AL Goughenour KD Wüthrich M Rajaram MVS Schlesinger LS Klein BS Rappleye CA O-Mannosylation of Proteins Enables <i>Histoplasma</i> Yeast Survival at Mammalian Body Temperatures. MBio . 2018 Jan 2;9(1)
[PubMed ID: 29295913]
Hernández-Santos N Klein BS Through the Scope Darkly: The Gut Mycobiome Comes into Focus. Cell Host Microbe . 2017 Dec 13;22(6):728-729
[PubMed ID: 29241038]
Wiesner DL Klein BS Lung epithelium: barrier immunity to inhaled fungi and driver of fungal-associated allergic asthma. Curr Opin Microbiol . 2017 Dec;40:8-13
[PubMed ID: 29096195]
Wiesner DL Klein BS The balance between immunity and inflammation. Science . 2017 Sep 8;357(6355):973-974
[PubMed ID: 28883060]
Lorenzini J Scott Fites J Nett J Klein BS Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR<sup>+</sup> CXC chemokines altering their effects on neutrophils. Cell Microbiol . 2017 Sep;19(9)
[PubMed ID: 28346820]
McBride JA Gauthier GM Klein BS Clinical Manifestations and Treatment of Blastomycosis. Clin Chest Med . 2017 Sep;38(3):435-449
[PubMed ID: 28797487]
Wang H Lee TJ Fites SJ Merkhofer R Zarnowski R Brandhorst T Galles K Klein B Wüthrich M Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination. PLoS Pathog . 2017 Aug;13(8):e1006568
[PubMed ID: 28793349]
Nanjappa SG McDermott AJ Fites JS Galles K Wüthrich M Deepe GS Jr Klein BS Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells. PLoS Pathog . 2017 May;13(5):e1006356
[PubMed ID: 28542595]
Wiemann P Perevitsky A Lim FY Shadkchan Y Knox BP Landero Figueora JA Choera T Niu M Steinberger AJ Wüthrich M Idol RA Klein BS Dinauer MC Huttenlocher A Osherov N Keller NP Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell Rep . 2017 May 2;19(5):1008-1021
[PubMed ID: 28467895]