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Barbara E.K. Klein, MD, MPH

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Barbara E.K. Klein, MD, MPH Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Klein is co-director of the Beaver Dam Eye Study, which collects information on the prevalence and incidence of age-related cataract, macular degeneration,and diabetic retinopathy, which are all common eye diseases in an aging population. The study also has examined other aging issues, such as overall health, quality-of-life and environmental and medicinal exposures.


Eye Care Services (Ophthalmology)



University Station Clinic
(608) 263-7171 | (800) 323-8942 | Map

Hospital Affiliation(s)

University Hospital
Veterans Hospital - Wm. S. Middleton Memorial

UW School of Medicine and Public Health

Department of Ophthalmology and Visual Sciences

Professional Certifications and Education

Board Certification Ophthalmology
Preventive Medicine
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship Bellevue Hospital, New York, NY
New York University Medical Center, New York, NY
Medical School New York University, New York, NY

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.
PubMed Articles
Roshandel D Gubitosi-Klug R Bull SB Canty AJ Pezzolesi MG King GL Keenan HA Snell-Bergeon JK Maahs DM Klein R Klein BEK Orchard TJ Costacou T Weedon MN DCCT/EDIC Research Group. Oram RA Paterson AD Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes. Diabetologia . 2018 Feb 5;
[PubMed ID: 29404672]
Folsom AR Lutsey PL Klein R Klein BE Tang W Retinal microvascular signs and incidence of abdominal aortic aneurysm: The Atherosclerosis Risk in Communities Study. Ophthalmic Epidemiol . 2017 Dec 27;:1-4
[PubMed ID: 29281316]
Sobrin L Chong YH Fan Q Gan A Stanwyck LK Kaidonis G Craig JE Kim J Liao WL Huang YC Lee WJ Hung YJ Guo X Hai Y Ipp E Pollack S Hancock H Price A Penman A Mitchell P Liew G Smith AV Gudnason V Tan G Klein BEK Kuo J Li X Christiansen MW Psaty BM Sandow K Asian Genetic Epidemiology Network Consortium. Jensen RA Klein R Cotch MF Wang JJ Jia Y Chen CJ Chen YI Rotter JI Tsai FJ Hanis CL Burdon KP Wong TY Cheng CY Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes . 2017 Dec;66(12):3130-3141
[PubMed ID: 28951389]
Klein R Lee KE Maynard JD Meuer SM Gangnon RE Klein BEK Skin Intrinsic Fluorescence and Age-Related Macular Degeneration: The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci . 2017 Dec 1;58(14):6328-6333
[PubMed ID: 29242907]
Cruickshanks KJ Nondahl DM Johnson LJ Dalton DS Fisher ME Huang GH Klein BE Klein R Schubert CR Generational Differences in the 5-Year Incidence of Age-Related Macular Degeneration. JAMA Ophthalmol . 2017 Dec 1;135(12):1417-1423
[PubMed ID: 29145549]
Mehta R Hodakowski A Cai X Lee KE Kestenbaum BR de Boer IH Fawzi A Wong TY Ix J Klein B Klein R Isakova T Serum Phosphate and Retinal Microvascular Changes: The Multi-Ethnic Study of Atherosclerosis and the Beaver Dam Eye Study. Ophthalmic Epidemiol . 2017 Dec;24(6):371-380
[PubMed ID: 28402694]
Loomis SJ Klein AP Lee KE Chen F Bomotti S Truitt B Iyengar SK Klein R Klein BEK Duggal P Exome Array Analysis of Nuclear Lens Opacity. Ophthalmic Epidemiol . 2017 Nov 28;:1-5
[PubMed ID: 29182452]
Dauer LT Ainsbury EA Dynlacht J Hoel D Klein BEK Mayer D Prescott CR Thornton RH Vano E Woloschak GE Flannery CM Goldstein LE Hamada N Tran PK Grissom MP Blakely EA Guidance on radiation dose limits for the lens of the eye: overview of the recommendations in NCRP Commentary No. 26. Int J Radiat Biol . 2017 Oct;93(10):1015-1023
[PubMed ID: 28346025]
Lin H Mares JA LaMonte MJ Brady WE Sahli MW Klein R Klein BEK Nie J Millen AE Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study. Ophthalmic Epidemiol . 2017 Oct;24(5):311-322
[PubMed ID: 28332910]
Klein R Horak K Lee KE Danforth L Cruickshanks KJ Tsai MY Gangnon RE Klein BEK The Relationship of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE) and Carboxymethyl Lysine (CML) to the Incidence of Diabetic Nephropathy in Persons With Type 1 Diabetes. Diabetes Care . 2017 Sep;40(9):e117-e119
[PubMed ID: 28630056]
Schubert CR Cruickshanks KJ Fischer ME Chen Y Klein BEK Klein R Pinto AA Sensory Impairments and Cognitive Function in Middle-Aged Adults. J Gerontol A Biol Sci Med Sci . 2017 Aug 1;72(8):1087-1090
[PubMed ID: 28535277]
Petrie JR Chaturvedi N Ford I Brouwers MCGJ Greenlaw N Tillin T Hramiak I Hughes AD Jenkins AJ Klein BEK Klein R Ooi TC Rossing P Stehouwer CDA Sattar N Colhoun HM REMOVAL Study Group. Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol . 2017 Aug;5(8):597-609
[PubMed ID: 28615149]
Klein BEK Horak KL Maynard JD Lee KE Klein R Association of Skin Intrinsic Fluorescence with Retinal Microvascular Complications of Long Term Type 1 Diabetes in the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Ophthalmic Epidemiol . 2017 Aug;24(4):211-216
[PubMed ID: 28287861]
Holzinger ER Verma SS Moore CB Hall M De R Gilbert-Diamond D Lanktree MB Pankratz N Amuzu A Burt A Dale C Dudek S Furlong CE Gaunt TR Kim DS Riess H Sivapalaratnam S Tragante V van Iperen EPA Brautbar A Carrell DS Crosslin DR Jarvik GP Kuivaniemi H Kullo IJ Larson EB Rasmussen-Torvik LJ Tromp G Baumert J Cruickshanks KJ Farrall M Hingorani AD Hovingh GK Kleber ME Klein BE Klein R Koenig W Lange LA MÓ“rz W North KE Charlotte Onland-Moret N Reiner AP Talmud PJ van der Schouw YT Wilson JG Kivimaki M Kumari M Moore JH Drenos F Asselbergs FW Keating BJ Ritchie MD Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. BioData Min . 2017;10:25
[PubMed ID: 28770004]
Thomas B Matsushita K Abate KH Al-Aly Z Ärnlöv J Asayama K Atkins R Badawi A Ballew SH Banerjee A Barregård L Barrett-Connor E Basu S Bello AK Bensenor I Bergstrom J Bikbov B Blosser C Brenner H Carrero JJ Chadban S Cirillo M Cortinovis M Courville K Dandona L Dandona R Estep K Fernandes J Fischer F Fox C Gansevoort RT Gona PN Gutierrez OM Hamidi S Hanson SW Himmelfarb J Jassal SK Jee SH Jha V Jimenez-Corona A Jonas JB Kengne AP Khader Y Khang YH Kim YJ Klein B Klein R Kokubo Y Kolte D Lee K Levey AS Li Y Lotufo P El Razek HMA Mendoza W Metoki H Mok Y Muraki I Muntner PM Noda H Ohkubo T Ortiz A Perico N Polkinghorne K Al-Radaddi R Remuzzi G Roth G Rothenbacher D Satoh M Saum KU Sawhney M Schöttker B Shankar A Shlipak M Silva DAS Toyoshima H Ukwaja K Umesawa M Vollset SE Warnock DG Werdecker A Yamagishi K Yano Y Yonemoto N Zaki MES Naghavi M Forouzanfar MH Murray CJL Coresh J Vos T Global Burden of Disease 2013 GFR Collaborators. CKD Prognosis Consortium. Global Burden of Disease Genitourinary Expert Group. Global Cardiovascular and Renal Outcomes of Reduced GFR. J Am Soc Nephrol . 2017 Jul;28(7):2167-2179
[PubMed ID: 28408440]
Xie J Ikram MK Cotch MF Klein B Varma R Shaw JE Klein R Mitchell P Lamoureux EL Wong TY Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy With Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Ophthalmol . 2017 Jun 1;135(6):586-593
[PubMed ID: 28472362]
Schubert CR Fischer ME Pinto AA Klein BEK Klein R Cruickshanks KJ Odor detection thresholds in a population of older adults. Laryngoscope . 2017 Jun;127(6):1257-1262
[PubMed ID: 28000220]
Fischer ME Cruickshanks KJ Nondahl DM Klein BEK Klein R Pankow JS Tweed TS Dalton DS Paulsen AJ Dichotic Digits Test Performance Across the Ages: Results From Two Large Epidemiologic Cohort Studies. Ear Hear . 2017 May Jun;38(3):314-320
[PubMed ID: 27941404]
Schubert CR Fischer ME Pinto AA Klein BEK Klein R Tweed TS Cruickshanks KJ Sensory Impairments and Risk of Mortality in Older Adults. J Gerontol A Biol Sci Med Sci . 2017 May 1;72(5):710-715
[PubMed ID: 26946102]
Chen Y Nondahl DM Schubert CR Klein BE Klein R Cruickshanks KJ The Relation between Sleep Disruption and Cataract in a Large Population-Based Study. Ophthalmic Epidemiol . 2017 Apr;24(2):111-115
[PubMed ID: 28139160]