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American Family Children's Hospital
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The Small Molecule Screening and Synthesis Facility (SMSSF) fosters collaborative drug discovery research between chemists, biologists and physician scientists that leads to the identification of new small molecules that inhibit disease targets and phenotypes in biochemical and cellular models relevant to any therapeutic area.

 

Our drug discovery services include:

News and Accomplishments

 

Scott Wildman, PhD has recently joined the Small Molecule Screening Facility.  Scott is a computational chemist with expertise in drug design, molecular modeling, virtual screening and HTS hit triage. He will be collaborating with investigators from across campus to identify and optimize the design of small molecules and peptides that interact with targets of therapeutic and biological interest. Scott comes to UW from Washington University in St. Louis where he was a Research Assistant Professor in the Department of Biochemistry and Molecular Biophysics, and the Scientific Director of both the High-throughput Screening Core and Peptide Synthesis Core.  Prior to that, he worked at Pfizer for 7 years on a wide variety of drug targets, moving two molecules into clinical trials. He has a PhD in Medicinal Chemistry from the University of Michigan.

 

Tip-less, acoustic liquid dispensing of aqueous and DMSO solutions in 2.5nanoliter(!) and up volumes into 96, 384 and 1536-well plates is now available for any application on an Echo 555.


SMSSF is the home of a new Seahorse Bioscience XFe96 Extracellular Flux Analyzer which simultaneously interrogates mitochondrial respiration and glycolysis - in a microplate, in real-time. The XFe96 Analyzer determines in vitro oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in order to assess cellular functions such as oxidative phosphorylation, glycolysis and fatty acid oxidation.


With pilot project funding from Institute for Clinical and Translational Research (ICTR), the UW Carbone Cancer Center (UWCCC) and use of the UW Center for High-throughput computing, we have expanded our virtual screening capabilities to two million compounds on one binding pocket in one run and queries of over 100 protein binding pockets for compound binding.

 

View the Small Molecule Screening and Synthesis Facility's Scientific Accomplishments

 

Acknowledging SMSSF

 

Funding received from the UWCCC Cancer Center Support Grant (CCSG) for published research, including the use of UWCCC Shared Resources to generate or analyze data, or conduct clinical trials, needs to reference the UWCCC. See Acknowledging UWCCC in Publications, Posters and Presentations

 

View the UW Drug Discovery and Development website for more information on other UW-Madison laboratory facilities that provide state-of-the-art instrumentation and expert scientific staff.

 

 

CONTACT INFORMATION

Faculty Leader
Michael Hoffmann 
(608) 265-8687 

Facility Managers
Chemistry 
John Feltenberger 
(608) 263-2644

HTS and Profiling Assays
Gene Ananiev  
(608) 265-8687

Computational Modeling and Virtual Screening 
Ken Satyshur 

Location 
Wisconsin Institutes for Medical Research 
Room 6003 
1111 Highland Avenue
Madison, WI 53705

Advisory Board

Members