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Small Molecule Screening and Synthesis Facility Publications

Any published research which received funding from the University of Wisconsin Carbone Cancer Center (UWCCC) Support Grant (CCSG), including the use of UWCCC Shared Resources to generate or analyze data or conduct clinical trials, must reference the UWCCC. See Acknowledging UWCCC in Publications, Posters and Presentations. 

 

Research reported in the following publications utilized HTS, assay, chemistry or modeling services at Small Molecule Screening and Synthesis Facility.

 

Organometallics

Pusztai E, Toulokhonova S, Temple N, Albright H, Zakai U, Guo G, Guzei I, Hu R, West, R.

Synthesis and Photophysical Properties of Asymmetric Substituted Silafluorenes.

Organometallics. 2013;32(9):2529-2535. 

 Scientific Reports

Ozawa M, Shimojima M, Goto H, Watanabe S, Hatta Y, Kiso M, Furuta Y, Horimoto T, Peters N, Hoffmann FM, Kawaoka Y.

A cell-based screening system for influenza A viral RNA transcription/replication inhibitors.
Scientific Reports. 2013;3. 

Biochemistry Wagner EK, Nath N, Flemming R, Feltenberger JB, Denu JM.

Identification and Characterization of Small Molecule Inhibitors of a Plant Homeodomain Finger.

Biochemistry. 2012;51(41):8293-306.

Matrix Biology

Tomasini-Johansson BR, Johnson IA, Hoffmann FM, Mosher DF.

Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds.

Matrix Biol. 2012;31(6):360-7.

PLOS logo

Tebbets BStewart DLawry SNett JNantel AAndes DKlein BS.

Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay.

PLoS One. 2012;7(5).

 International Journal of Cancer

Khan N, Afaq F, Khusro FH, Adhami VM, Suh Y, Mukhtar H.
Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.
Int J Cancer. 2012;130(7):1695-705.

Organic Letters

Parrish JD, Ischay MA, Lu Z, Guo S, Peters NR, Yoon TP.

Endoperoxide synthesis by photocatalytic aerobic [2 + 2 + 2] cycloadditions.
Org Lett. 2012;14(6):1640-3.

Journal of Biological chemistry cover Ding Y, Ko MH, Pehar M, Kotch F, Peters NR, Luo Y, Salamat SM, Puglielli L.
Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.
J Biol Chem. 2012;287(11):8424-33.
PLOS logo

Powell E, Shanle E, Brinkman A, Li J, Kales S, Wisinski K, and Xu W.

Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ. PLoS One. 2012;7(2).

Methods in Enzymology

Wagner EK, Albaugh BN, Denu JM.

High-throughput strategy to identify inhibitors of histone-binding domains.

Methods Enzymol. 2012;512:161-85.

Antiviral Research

Huang HS, Pyeon D, Pearce SM, Lank SM, Griffin LM, Ahlquist P, Lambert PF.

Novel antivirals inhibit early steps in HPV infection.

Antiviral Res. 2012;93(2):280-7.

biochem pharma

Shanle, EK, Hawse JR, Xu W.

Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands.

Biochem Pharmacol. 2011;82(12):1940-9.

 The Journal of Immunology Wiemer AJ, Hegde S, Gumperz JE, Huttenlocher A.
A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist.
J Immunol. 2011;187(7):3663-70.
 Journal of Surgical Research Phan T, Yu X, Kunnimalaiyaan M, Chen H. 
Antiproliferative effect of chrysin on anaplastic thyroid cancer.
J Surg Res. 2011;170(1):84-8.
 Annuals of Surgical Oncology Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H. Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer.
Ann Surg Oncol. 2011;18(5):1506-11.
nature methods journal cover Chen G, Gulbranson DR, Hou Z, Bolin JM, Ruotti V, Probasco MD,
Smuga-Otto K, Howden SE, Diol NR, Propson NE, Wagner R, Lee GO, Antosiewicz-Bourget J, Teng JM, Thomson JA.

Chemically defined conditions for human iPSC derivation and culture. 

Nat Methods. 2011;8(5):424-9.

 FASEB Journal

Siddiqui IA, Asim M, Hafeez BB, Adhami VM, Tarapore RS, Mukhtar H.
Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer.
FASEB J. 2011;25(4):1198-207.

 Archives of Biochemistry and Biophysics

Bhatia N, Yang B, Xiao TZ, Peters N, Hoffmann FM, Longley BJ.
Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1.

Arch Biochem Biophys. 2011;508(2):217-21.

 Cancer

Pinchot SN, Jaskula-Sztul R, Ning L, Peters NR, Cook MR, Kunnimalaiyaan M, Chen H.
Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method.
Cancer. 2011;117(7):1386-98.

 American Journal of Surgery

Zarebczan B, Pinchot SN, Kunnimalaiyaan M, Chen H.
Hesperetin, a potential therapy for carcinoid cancer.
Am J Surg. 2011;201(3):329-32; discussion 333.  

PLOS logo

Schiro MM, Stauber SE, Peterson TL, Krueger C, Darnell SJ, Satyshur KA, Drinkwater NR, Newton MA, Hoffmann FM.
Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression.
PLoS One. 2011;6(9).

Journal of Antibiotics - Tokyo

Yu Z, Zhao LX, Jiang CL, Duan Y, Wong L, Carver KC, Schuler LA, Shen B.

Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209.
J Antibiot (Tokyo). 2011;64(1):159-62.

Journal of Biological chemistry cover Maurer LM, Tomasini-Johansson BR, Ma W, Annis DS, Eickstaedt NL, Ensenberger MG, Satyshur KA, Mosher DF.

Extended binding site on fibronectin for the functional upstream domain of protein F1 of Streptococcus pyogenes.
J Biol Chem. 2010;285(52):41087-99. Erratum in: J Biol Chem. 2011;286(33).

PNAS Kolonko EM, Albaugh BN, Lindner SE, Chen Y, Satyshur KA, Arnold KM, Kaufman PD, Keck JL, Denu JM.
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone.
Proc Natl Acad Sci U S A. 2010;107(47):20275-80. 
biochem pharma Powell E, Huang SX, Xu Y, Rajski SR, Wang Y, Peters N, Guo S, Xu HE, Hoffmann FM, Shen B, Xu W.

Identification and characterization of a novel estrogenic ligand actinopolymorphol A. 

Biochem Pharmacol. 2010;80(8):1221-9.

Cell Stem Cell

Chen G, Hou Z, Gulbranson DR, Thomson JA.

Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells.

Cell Stem Cell. 2010;7(2):240-8.

Antimicrobial agents and chemotherapy Jasenosky, LD, Neumann, G, Kawaoka, Y.
Minigenome-Based Reporter System Suitable for High-Throughput Screening of Compounds Able To Inhibit EbolavirusReplication and/or Transcription.
Antimicrobial Agents amd Chemotherapy. 2010;54(7):3007–3010.
Cancer Research Mehraein-Ghomi F, Basu HS, Church DR, Hoffmann FM, Wilding G. 
Androgen receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate cancer cells.
Cancer Research. 2010;70(11):4560-8.
Ca chemo pharma Basu HS, Mahlum A, Mehraein-Ghomi F, Kegel SJ, Guo S, Peters NR, Wilding G. 
Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA). 

Cancer Chemotherapy Pharmacology. 2010 May 30.

JACS

Luo Y, Li W, Ju J, Yuan Q, Peters N, Hoffmann FM, Huang Sheng-Xiong, Bugni TS, Rajski S, Osada H, Shen B.
Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. 
Journal of the American Chemical Society 2010;132(19):6663-71.

 Molecular Cancer Therapeutics journal cover

Cook MR, Pinchot SN, Jaskula-Sztul R, Luo J, Kunnimalaiyaan M, Chen H.

Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth. 

Mol Cancer Ther. 2010;9(2):429-37.

PNAS cover

Lu D, Bernstein DA, Satyshur KA, Keck JL.

Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance.

Proc Natl Acad Sci U S A. 2010;107(2):633-8.

Journal of Biomolecular Screening Ewald JA, Peters N, Desotelle JA, Hoffmann FM, Jarrard DF.

A high-throughput method to identify novel senescence-inducing compounds.

J Biomol Screen. 2009;14(7): 853-8.

JACS Ju J, Rajski SR, Lim Si-Kyu, Seo Jeong-Woo, Peters NR, Hoffmann FM, Shen B.
Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. 
Journal of the American Chemical Society. 2009;131(4):1370-1.
analytical biochemistry

Peterson KJ, Sadowsky JD, Scheef EA, Pal S, Kourentzi KD, Willson RC, Bresnick EH, Sheibani N, Gellman SH.

A Fluorescence Polarization Assay for Identifying Ligands that Bind to Vascular Endothelial Growth Factor.

Anal. Biochem. 2008;378(1):8-14.

bioorganic and medicinial chem Ju J, Rajski SR, Lim Si-Kyu, Seo Jeong-Woo, Peters NR, Hoffmann FM, Shen B.
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
Bioorganic & Medicinal Chemistry Letters, 2008;18(22):5951-4.
assay and drug development technologies Trubetskoy OV, Finel M, Kurkela M, Fitzgerald M, Peters NR, Hoffmann FM, Trubetskoy VS.
High throughput screening assay for UDP-glucuronosyltransferase 1A1 glucuronidation profiling.
Assay and Drug Development Technologies. 2007;5(3):343-54.

JACS

Ahmed, A, Peters, NR, Fitzgerald MK, Watson JA, Hoffmann, FM, Thorson JS.
Colchicine Glycorandomization Influences Cytotoxicity and Mechanism of Action.

Journal of the American Chemical Society. 2006;10.1021

/ja064686s.

 Chemistry and Biology Carlson EE, May JF, Kiessling LL.
Chemical probes of UDP-galactopyranose mutase.
Chemistry and Biology. 2006;13(8):825-37.
ChembioChem Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS.
RebG- and RebM-Catalyzed Indolocarbazole Diversification.
Chembiochem. 2006;7(5):795-804.
JMB

Rutkoski TJ, Kurten EL, Mitchell JC, Raines RT.
Disruption of Shape-Complementarity Markers to Create Cytotoxic Variants of Ribonuclease A.

Journal of Molecular Biology. 2005;354 (1):41-54.

PNAS Langenhan JM, Peters NR, Guzei IA, Hoffmann FM, Thorson JS.
Enhancing the Anti-Cancer Properties of Cardiac Glycosides via Neoglycorandomization.
Proc Natl Acad Sci USA. 2005;102(35):12305-10.
analytical biochemistry Kozlov M, Bergendahl V, Burgess R, Goldfarb A, Mustaev A.
Homogenous fluorescent assay for RNA polymerase.
Analytical Biochemistry. 2005;342(2):206-13.
Antimicrobial agents and chemotherapy Ason B, Knauss DJ, Balke AM, Merkel G, Skalka AM, Reznikoff WS.
Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors.
Antimicrobial Agents and Chemotherapy. 2005;49(5):2035-43.
 Journal of Lipid Research Kim, M, Wessely, V, Lan, Q.
Identification of Mosquito Sterol Carrier Protein-2 Inhibitors.
Journal of Lipid Research. 2005;46(4):650-7.
JACS Soltero-Higgin M, Carlson EE, Phillips JH, Kiessling LL.
Identification of inhibitors for UDP-galactopyranose mutase.
J Am Chem Soc. 2004;126(34):10532-3.
 Nucleic Acids Research Ason B, Reznikoff WS.
A high-throughput assay for Tn5 Tnp-induced DNA cleavage.
Nucleic Acids Res. 2004;32(10):e83.