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UW Health SMPH
American Family Children's Hospital


The Small Molecule Screening and Synthesis Facility (SMSSF) has specialized equipment dedicated to drug discovery. Scientists from UW-Madison, other universities or private companies may receive training on some pieces of the shared equipment and then use the online appointment system to schedule “walk-up” use.


HTS and Profiling Assay Equipment

Training and Scheduled Walk-up Use Available ($60/hour; minimum time 15 minutes) 

Liquid Handling (available in Biosafety Cabinet if sterile transfers needed)

  • Beckman Biomek 2000 eight-channel liquid handler 
  • Benchtop Pipetter 96 and Benchtop Pipetter 96-low volume
  • Biotek Microflo peristaltic reagent dispensers
  • Biotek ELx405 96-pin plate washer
  • Thermo Scientific Hydra 96-channel liquid handler

Plate Readers and Scanners

  • Biotek Synergy Multimode Plate reader
  • LI-COR Odyssey imaging system (scanner)
  • PerkinElmer Enspire plate reader for AlphaScreen
  • Tecan Safire2 plate reader
  • Wallac/PE 1420 VICTOR3 V plate reader

Walk-up Use Not Available

  • Beckman fX Liquid Handling (96 and 384)
  • Beckman 96-channel Multimek liquid handler
  • EVOS® FL Auto Cell Imaging System


Training and Scheduled Walk-up Use Available

  • Agilent Technologies 1200-Series HPLC
  • Teledyne Isco CombiFlash Rf-200 equipped with UV-Vis detector
  • Heidolph Laborota 4000 Rotary Evaporator
  • Virtis Sentry lyophilizer
  • Anton Paar Monowave 300 with a 24 position autosampler for microwave facilitated organic synthesis

Walk-up Use Not Available

To implement projects for SMSSF clients, staff chemists have access to the following equipment in the UW School of Pharmacy:

  • Varian Unity-Inova 400 MHz NMR Spectrometer
  • Varian Unity-Inova 500 MHz NMR Spectrometer
  • Bruker MaXis Ultra-High Resolution Quadrupole Time-of-Flight MS
  • Bruker Amazon ETD Ion Trap
  • AB Sciex Q-Trap 5500
  • Waters Acquity UPLC System
  • Waters Nano-Acquity UPLC System
  • Agilent 1100 HPLC-MSD SL Ion Trap Mass Spectrometer
  • Bruker Equinox 55/S FT-IR Spectrophotometer
  • Perkin-Elmer 599B IR Spectrophotometer
  • Hitachi F-3010 Fluorescence Spectrophotometer
  • Perkin-Elmer 241 Polarimeter



  • Dell T5500 molecular graphics computer (Intel dual quad Xeon 2.93GHz, Nvidia FX 4800 graphics)
  • Dell 3950 server (Intel dual quad Xeon 2.93GHz)
  • Dell T5500 molecular graphics computer (Intel dual quad, Nvidia FX 4800 graphics)
  • Sybyl molecular-modeling software, Surflex and Autodock4 molecular docking package, EPOS docking pocket identifier, FlexX, Grid docking, Pymol and ADT visualization software