Skip to Content
UW Health SMPH
American Family Children's Hospital
SHARE TEXT

Equipment

The Small Molecule Screening and Synthesis Facility (SMSSF) has specialized equipment dedicated to drug discovery. Scientists from UW-Madison, other universities or private companies may receive training on some pieces of the shared equipment and then use the online appointment system to schedule “walk-up” use.

 

HTS and Profiling Assay Equipment

Training and Scheduled Walk-up Use Available ($60/hour; minimum time 15 minutes) 

Liquid Handling (available in Biosafety Cabinet if sterile transfers needed)

  • Beckman Biomek 2000 eight-channel liquid handler 
  • Benchtop Pipetter 96 and Benchtop Pipetter 96-low volume
  • Biotek Microflo peristaltic reagent dispensers
  • Biotek ELx405 96-pin plate washer
  • Thermo Scientific Hydra 96-channel liquid handler

Plate Readers and Scanners

  • Biotek Synergy Multimode Plate reader
  • LI-COR Odyssey imaging system (scanner)
  • PerkinElmer Enspire plate reader for AlphaScreen
  • Tecan Safire2 plate reader
  • Wallac/PE 1420 VICTOR3 V plate reader

Walk-up Use Not Available

  • Beckman fX Liquid Handling (96 and 384)
  • Beckman 96-channel Multimek liquid handler
  • EVOS® FL Auto Cell Imaging System

Chemistry 

Training and Scheduled Walk-up Use Available

  • Agilent Techlologies 1200-Series HPLC
  • Teledyne Isco CombiFlash Rf-200 equipped with UV-Vis detector
  • Heidolph Laborota 4000 Rotary Evaporator
  • Virtis Sentry lyophilizer
  • Anton Paar Monowave 300 with a 24 position autosampler for microwave facilitated organic synthesis

Walk-up Use Not Available

To implement projects for SMSSF clients, staff chemists have access to the following equipment in the UW School of Pharmacy:

  • Varian Unity-Inova 400 MHz NMR Spectrometer
  • Varian Unity-Inova 500 MHz NMR Spectrometer
  • Bruker MaXis Ultra-High Resolution Quadrupole Time-of-Flight MS
  • Bruker Amazon ETD Ion Trap
  • AB Sciex Q-Trap 5500
  • Waters Acquity UPLC System
  • Waters Nano-Acquity UPLC System
  • Agilent 1100 HPLC-MSD SL Ion Trap Mass Spectrometer
  • Bruker Equinox 55/S FT-IR Spectrophotometer
  • Perkin-Elmer 599B IR Spectrophotometer
  • Hitachi F-3010 Fluorescence Spectrophotometer
  • Perkin-Elmer 241 Polarimeter

 

Computational

  • Dell T5500 molecular graphics computer (Intel dual quad Xeon 2.93GHz, Nvidia FX 4800 graphics)
  • Dell 3950 server (Intel dual quad Xeon 2.93GHz)
  • Dell T5500 molecular graphics computer (Intel dual quad, Nvidia FX 4800 graphics)
  • Sybyl molecular-modeling software, Surflex and Autodock4 molecular docking package, EPOS docking pocket identifier, FlexX, Grid docking, Pymol and ADT visualization software