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UW Health SMPH
American Family Children's Hospital
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Medicinal Chemistry

Medicinal chemistry expertise and services are available at the Medicinal Chemistry Center (MCC) in the UW School of Pharmacy.  The MCC is currently staffed by three PhD-level scientists: Dr. John Feltenberger, Dr. Zhi-Xiong Ma, and Dr. Zheng-Qing Ye.  The team has previously worked with over 40 individual UW-Madison laboratories across a broad range of projects requiring lead and probe discovery, hit-to-lead optimization, rational drug design, and scale-up synthesis for animal studies.

 

Available services include:

  • Development of small molecule probes (attachment of fluorophore, biotin, clickable tether, etc.)

  • Hit-to-lead optimization campaigns from validated screening hits

  • Rational drug design program

  • SAR analysis

  • Synthesis of known bioactive small molecules from the literature (not commercially available)

  • Scale-up synthesis of bioactive small molecules to support animal studies (up to multi-gram scale)

  • Purification of crude mixtures of compounds

  • Sample analysis (ie. NMR, MS, IR, m.p., optical rotation, HPLC purity)

 

Primary Contact:

 

Dr. John Feltenberger

Assistant Director

Phone: 608-263-2644

Fax: 608-262-5345

Email: medchem@pharmacy.wisc.edu