American Family Children's Hospital

Chemical and RNAi Libraries

Specialized Libraries 


Selleck FDA Approved Drug Library (received February 2015)

The Selleck FDA Approved Drug Library is a collection of 1018 FDA-approved drugs.

  • Related to oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc
  • Structurally diverse, medicinally active, and cell permeable
  • Documented structure, IC50, bioactivity and safety 

Selleck Kinase Inhibitor Library (received November 2013)

The Selleck Kinase Inhibitor Library is a unique collection of 273 kinase inhibitors 

  • Targets kinases such as RTKs, PI3K, Aurora Kinase, CDK, and MEK
  • Most are ATP competitive
  • Structurally diverse, medicinally active and cell permeable
  • Documented structure, IC50 and customer reviews 

Selleck Epigenetics Compound Library (received April 2015)

The Selleck Epigenetics Library is a collection of 128 compounds

  • Contains inhibitors of epigenetic enzymes including Histone Deacetylase (HDACs), SIRTs, Lysine demethylases, Histone Acetyltransferases (HATs), DNA Methyltransferase (Dnmts), and SIRTs activators
  • Structurally diverse, medicinally active, and cell permeable

Enzo Screen-Well Bioactive Lipid Library (received November 2013)

The Screen-Well™ Bioactive Lipid Library contains 195 bioactive lipids 

  • Includes: Endocannabinoids, Farnesyl/geranylgeranyl derivatives, HETEs, deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA and phosphatidic acids, Octadecanoids, PAFs, Prostaglandins and thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids.

GlaxoSmithKline (GSK) Protein Kinase Inhibitor Set (received March 2013, July 2014)

The Protein Kinase Inhibitor Set (PKIS1 and PKIS2) consists of 868 small molecule kinase inhibitors that have been published by GSK. 

  • Representing a range of chemotypes as well as multiple exemplars within a given chemotype
  • Broad coverage of kinase targets, characterized across a panel of 220 kinase assays. 


The NCI04 "Diversity Set III" library (received 10-18-2012) consists of 1597 compounds.


The NCI05 "Mechanistic Diversity Set" library (received 10-18-2012) consists of 879 compounds which have represent a broad range of structural diversity and patterns of growth inhibition in the NCI 60 cell line screen.


The NCI06 "Natural Product Set II" library (received 10-18-2012) consists of 117 natural products that were selected from the NCI open repository.


The NCI07 "Approved Oncology Set IV" library (received 10-18-2012) includes 101 compounds.


More information about these libraries can be found on the NCI/NIH Developmental Therapeutics Program website for Synthetics and Pure National Products Repositories and Basic Chemical Data.


TimTec Anti-Infectives (received July 2014)

Anti-Infectives Library includes 960 molecules 

  • Contains low molecular weight, drug-like molecules with scaffolds found in antiseptic agents with anti-bacterial (Gram+ve and Gram-ve), anti-fungoid, anti-microbial activities.

Prestwick Chemical Library (received January 2011)

The Prestwick Chemical Library® contains 1280 marketed drugs.


The Spectrum Collection (received January 2010)

The Spectrum Library contains 2000 structurally diverse compounds 

  • Selected by medicinal chemists and biologists for a wide range of biological activities


Diversity Libraries


Life Chemicals (received, #1- January 2009, #2- October 2009, #3- November 2015)

The Life Chemicals diversity libraries (LifeCHEM1 LifeCHEM2 and LifeCHEM3) total 75,000 diverse compounds, arrayed in groups of 10,000, 15,000 and two groups of 25,000.


Maybridge (received, October 2008)

The Maybridge HitFinder collection consists of 14,400 compounds representing the drug-like diversity of the Maybridge compound catalog.


MLPCN: NIH Molecular Libraries Probe Production Centers Network Diversity Library (received, May 2014)

The MLPCN library consists of 340,364 small molecule probes, covering a wide range of chemical space.


NCI NExT Diversity Library (requested as needed from NCI for oncology-related HTS campaigns that received funding through a peer-viewed process)

The set contains a variety of chemical scaffolds across ten commercial suppliers, while keeping within the boundaries of drug-like chemical space (e.g. Lipinski's Rule of 5, high QED scores). The collection includes a total of 83,536 compounds.