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UW Health SMPH
American Family Children's Hospital

The mission of the UW Carbone Cancer Center (UWCCC) Human Cancer Virology (VR) Scientific Program is to advance the understanding, prevention and treatment of virus-associated cancers and other cancers.  Specific human tumor viruses have been causally associated with at least 15-20% of all human cancers.


Program Leaders

Paul Ahlquist, PhDShannon C. Kenney, MD


The VR Program is advancing understanding, prevention, and treatment of virus-linked cancers and other cancers through fundamental and translational studies that encompass five of the seven well-established human tumor viruses. Program members are defining the mechanisms by which human tumor viruses replicate, maintain chronic infection, and promote tumor induction and maintenance; determining the progressive, genome-wide molecular changes in the development of virus-associated tumors; identifying viral and cellular biomarkers for improved tumor diagnosis, prognosis and treatment selection; and using their results to develop new approaches to prevent and treat tumor virus infection and oncogenesis.  To achieve their goals, Program members collaborate extensively intra- and inter-programmatically, and integrate novel, synergistic approaches using cell culture, mouse models based on transgenes and patient explants, and large collections of relevant human tumor samples.